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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for  Cell Cycle/Checkpoint

  1. Cat.No. 产品名称 Information
  2. GC64278 RP-3500

    RP-3500; ATR inhibitor 4

     RP-3500 (Camonsertib, ATR inhibitor) is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM.
  3. GC64273 AMXI-5001 AMXI-5001 是一种有效的、具有口服活性的 parp1/2 和微管聚合抑制剂。MXI-5001 对多种人类癌细胞表现出选择性抗肿瘤细胞毒性，其 IC50s 比现有的临床 PARP1/2 抑制剂低得多。AMXI-5001 诱导已建立的肿瘤完全消退，包括非常大的肿瘤。
  4. GC64085 KIF18A-IN-1

    KIF18A-IN-1 是一种有丝分裂驱动蛋白 KIF18A 的抑制剂，具有抗肿瘤活性。详细信息请参考专利文献 WO2021026098A1 中的化合物 100-13。
  5. GC64019 Sovilnesib

    AMG 650

     AMG 650 (Sovilnesib) is an oral, first in class, selective kinesin-like protein KIF18A inhibitor, can be used for the research of cancer.
  6. GC63977 BMVC2

    o-BMVC

     BMVC2 (o-BMVC) 是 BMVC 的双取代咔唑衍生物，是一种 G 四联体 (G4) 稳定剂。
  7. GC63958 6α-Hydroxy Paclitaxel-d5

    紫杉醇杂质

     6α-Hydroxy Paclitaxel-d5 是 6α-Hydroxy paclitaxel 的氘代物。6α-Hydroxy paclitaxel 是紫杉醇的初级代谢物。6α-Hydroxy paclitaxel 对有机阴离子转运多肽 1B1/SLCO1B1 (OATP1B1) 具有与紫杉醇相似的时间依赖性抑制效力，但它对 OATP1B3 不具有时间依赖性作用。6α-Hydroxy paclitaxel 可用于癌症研究。
  8. GC63845 Eribulin-d3 mesylate

    甲磺酸艾日布林 d3 (甲磺酸盐)

     Eribulin-d3 mesylate 是 Eribulin mesylate 的氘代物。Eribulin mesylate 是靶向微管 (microtubule) 的抗癌剂，可用于研究癌症。
  9. GC49744 GRP94 Monoclonal Antibody (Clone 9G10) For immunochemical detection of GRP94
  10. GC49742 Hsf1 Monoclonal Antibody (Clone 10H8) For immunochemical analysis of Hsf1
  11. GC49740 Brevetoxin 3

    PbTx-3

     A neurotoxin
  12. GC49736 10-acetyl Docetaxel

    多西他赛,10-Acetyl docetaxel; PNU-101383

     A derivative of paclitaxel and an inhibitor of microtubule depolymerization
  13. GC49735 Thallos AM

    Thallos Acetoxymethyl ester

     A cell-permeable fluorescent thallium indicator
  14. GC49724 BIO-1211 (trifluoroacetate salt) A peptide inhibitor of α4β1 integrin
  15. GC49723 SenTraGor™ Cell Senescence Reagent

    GL13, SBB-A-B, SBB-Analogue (GL13) Biotin

    A cellular senescence detection reagent
  16. GC49713 SIKVAV (acetate)

    Hexapeptide-10, Ser-Ile-Lys-Val-Ala-Val

     A laminin α1-derived peptide
  17. GC49709 cyclo(RGDyC) (trifluoroacetate salt)

    c(RGDyC), cyclo(Arg-Gly-Asp-D-Tyr-Cys)

     A cyclic pentapeptide
  18. GC49704 Ac-FLTD-CMK (trifluoroacetate salt)

    Ac-Phe-Leu-Thr-Asp-CMK

     An inhibitor of caspase-1, -4, -5, and -11
  19. GC49702 Papain Inhibitor (trifluoroacetate salt)

    GGYR, Gly-Gly-Tyr-Arg

     A peptide inhibitor of papain
  20. GC49699 Acetyl Tetrapeptide-9 (acetate)

    AcTP1, N-acetyl-Gln-Asp-Val-His

     A synthetic signal peptide
  21. GC49695 FKBP52 Monoclonal Antibody (Clone Hi52C) For immunochemical analysis of FKBP52
  22. GC49687 Goralatide (acetate)

    N-Acetyl-Ser-Asp-Lys-Pro, AcSDKP

     A tetrapeptide regulator of hematopoiesis
  23. GC49685 Trifluoroacetyl Tripeptide-2 (acetate)

    F3Ac-Val-Tyr-Val

     A peptide inhibitor of pancreatic and neutrophil elastases
  24. GC49684 Dabigatran-13C-d3

    BIBR 953-13C,d3; BIBR 953ZW-13C,d3

     An internal standard for the quantification of dabigatran
  25. GC49682 Dabigatran-d3

    BIBR 953-d3; BIBR 953ZW-d3

     An internal standard for the quantification of dabigatran
  26. GC49674 Schizandrin

    五味子醇甲; Schizandrin; Schizandrol; Schizandrol-A

     A lignan with diverse biological activities
  27. GC49605 H-Gly-Pro-Hyp-OH (acetate)

    H-GP-Hyp-OH, Tripeptide-29

     A peptide DPP-4 inhibitor
  28. GC49547 L-Glutamic Acid γ-p-Nitroanilide (hydrate)

    γ-Glu-pNA, Glutamate γ-(4-Nitroanilide), L-GPNA, E-pNA

     A colorimetric substrate for γ-glutamyl transpeptidase
  29. GC49532 S-(1,2-Dichlorovinyl)-Cysteine (hydrochloride)

    S-(1,2-dichlorovinyl)-L-Cysteine, S-(trans-1,2-dichlorovinyl)-L-Cysteine, DCVC

     A nephrotoxin and metabolite of trichloroethylene
  30. GC49491 N′-Nitrosonornicotine-d4

    氘代N-亚硝基降烟碱(NNN)

     An internal standard for the quantification of N'-nitrosonornicotine
  31. GC49482 (±)-Nornicotine-d4

    氘代降烟碱

     An internal standard for the quantification of (±)-nornicotine
  32. GC49471 LAMP1 Monoclonal Antibody (Clone Ly1C6) For immunochemical analysis of LAMP1
  33. GC49469 IPG-1 TMA

    APG-1, Asante Potassium Green-1, ION Potassium Green-1

     A cell-impermeable fluorescent potassium indicator
  34. GC49468 IPG-1 AM

    APG-1 AM, Asante Potassium Green-1 AM, ION Potassium Green-1 AM, IPG-1 Acetoxymethyl ester

     A cell-permeable fluorescent potassium indicator
  35. GC49466 IPG-2 TMA

    APG-2, Asante Potassium Green-2, ION Potassium Green-2, IPG-2

     A cell-impermeable fluorescent potassium indicator
  36. GC49463 IPG-2 AM

    APG-2 Acetoxymethyl ester, APG-2 AM, Asante Potassium Green-2 Acetoxymethyl ester, Asante Potassium Green-2 AM, ION Potassium Green-2 Acetoxymethyl ester, ION Potassium Green-2 AM, IPG-2 Acetoxymethyl ester

     A cell-permeable fluorescent potassium indicator
  37. GC49460 ING-2 AM

    ANG-2 Acetoxymethyl ester, ANG-2 AM, Asante Natrium Green-2 Acetoxymethyl ester, Asante Natrium Green-2 AM, ING-2 Acetoxymethyl ester, ION Natrium Green-2 Acetoxymethyl ester, ION Natrium Green-2 AM

     A cell-permeable fluorescent sodium indicator
  38. GC19897 Albendazole Sulfone

    阿苯达唑砜

     An active metabolite of albendazole
  39. GC63774 MMAF-d8 hydrochloride D8-MMAF hydrochloride是MMAF hydrochloride的氘代形式。
  40. GC63740 PF-06380101-d8

    Aur0101-d8; Auristatin-0101-d8

     PF-06380101 D8 (Aur0101 D8) 是 PF-06380101 的氘代物。PF-06380101 是一种 Auristatin 微管抑制剂，是一种细胞毒性 Dolastatin 10 类似物。
  41. GC63716 Sovesudil hydrochloride

    PHP-201 hydrochloride; AMA0076 hydrochloride

     Sovesudil (PHP-201) hydrochloride 是一种有效的、ATP 竞争性局部作用 Rho 激酶 (ROCK) 抑制剂，对 ROCK I 和 ROCK II 的 IC50 分别为 3.7和2.3 nM。Sovesudil hydrochloride 可降低眼压而不引起充血。
  42. GC63663 Avanbulin

    BAL27862

     Avanbulin (BAL27862) 是一种有效的秋水仙碱位点结合的微管蛋白 (tubulin) 装配抑制剂。Avanbulin 在 37 °C 抑制微管蛋白组装 (IC50=1.4 μM)。Avanbulin 与微管蛋白结合的 Kd 值为 244 nM。Avanbulin 可用于癌症和细胞分裂的研究。
  43. GC63596 Fmoc-MMAE Fmoc-MMAE 是保护基团共轭连接到 MMAE。Mc-MMAE 是有效的微管蛋白抑制剂，可用于偶联抗体。
  44. GC63576 10074-A4 10074-A4 是一种 c-Myc 结合化合物，与 c-Myc370–409 结合，表现得像“蛋白质云”周围的“配体云”，具有与非结合配体截然不同的特征。具有抗癌作用
  45. GC63461 MMAE-d8

    Monomethyl auristatin E-d8; Deuterated labeled MMAE

     MMAE-d8是一种氘化标记的一甲基澳瑞他汀E（MMAE）， 可用于MMAE的检测。
  46. GC63351 Sovesudil

    PHP-201; AMA0076

     Sovesudil (PHP-201) 是一种有效的、ATP 竞争性局部作用 Rho激酶 (ROCK) 抑制剂，对 ROCK I 和 ROCK II 的 IC50 分别为 3.7 和 2.3 nM。Sovesudil 降低眼压而不引起充血。
  47. GC63333 Cotosudil Cotosudil 是一种 ROCK 激酶抑制剂，可用于青光眼或高眼压症的研究。
  48. GC49443 7α-hydroxy Cholesterol

    胆甾-5-烯-3,7二醇

     An oxysterol and bile acid precursor
  49. GC63253 Verosudil

    AR-12286

     Verosudil (AR-12286) 是一种有效的 Rho 激酶 (ROCK) 抑制剂，对 ROCK1 和 ROCK2 的 Ki 分别为 2 和 2 nM。AR-12286 主要通过增加眼房水通过小梁网流出来降低眼压。
  50. GC63211 Tau tracer 2

    Pl-2620

     Tau tracer 2 (Pl-2620) 是一种 Tau 示踪剂，用于 Tau 蛋白聚集体成像。Tau tracer 2 可用于诊断神经退行性疾病。
  51. GC63165 RAD51-IN-1 RAD51-IN-1 是 B02 的衍生物，是 RAD51 的有效抑制剂。 RAD51-IN-1 可用于癌症研究。

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