Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC49205 L-Leu-AMC (hydrochloride)
L-亮氨酰7-氨基-4-甲基香豆素盐酸盐,Leu-AMC hydrochloride
A fluorogenic substrate for leucine aminopeptidase
GC49204 Nefazodone-d6 (hydrochloride)
BMY-13754-d6; MJ-13754-1-d6
An internal standard for the quantification of nefazodone
GC49186 O-Demethyl Apremilast
阿普斯特杂质
An active metabolite of apremilast
GC49163 N’-Nitrosonornicotine
N-亚硝基降烟碱(NNN)
An N-nitrosamine and a carcinogen
GC49145 Z-FR-AMC (trifluoroacetate salt)
Z-FR-7-amino-4-Methylcoumarin, Z-Phe-Arg-AMC
A fluorogenic substrate for cathepsin L
GC49142 Isorhoifolin
异野漆树苷
A flavonoid glycoside with diverse biological activities
GC49128 Phenylbutazone-d9
保泰松 d9
An internal standard for the quantification of phenylbutazone
GC49124 EN219 An RNF114 recruiter
GC49108 Racecadotril-d5
消旋卡多曲杂质,Acetorphan-d5
An internal standard for the quantification of racecadotril
GC49093 Safflower Red
红花黄色素
A red pigment with diverse biological activities
GC49089 FR900359
UBO-QIC

A cyclic depsipeptide and an inhibitor of Gα_q, Gα₁₁, and Gα₁₄
GC49077 Podophyllotoxin-d6
PPT-d6
An internal standard for the quantification of podophyllotoxin and picropodophyllotoxin
GC49072 Tribenoside
三苄糖甙
A vasoprotective agent
GC49065 Metacetamol
N-(3-羟基苯基)乙酰胺
A derivative of acetaminophen
GC49042 Benastatin A A bacterial metabolite with diverse biological activities
GC49024 Palmitic Acid MaxSpec® Standard
棕榈酸
A long-chain saturated fatty acid
GC49023 Palmitic Acid-d9 MaxSpec® Standard
棕榈酸-13,13,14,14,15,15,16,16,16-D9
A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
GC49015 Phenethyl isothiocyanate
2-苯基乙基异硫代氰酸酯
An isothiocyanate with anticancer activity
GC49014 Palmitoyl Tetrapeptide-7 (acetate)
N-Palmitoylrigin, Pal-Gly-Gln-Pro-Arg-OH
A cosmeceutical peptide
GC49002 Sinigrin (hydrate)
黑芥子硫苷酸钾一水；芥子甙单水合物
A glucosinolate with diverse biological activities
GC48995 Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt) A fluorogenic substrate of enteropeptidase
GC48992 CGP 77675 (hydrate) An inhibitor of Src family kinases
GC48986 9-hydroxy Stearic Acid
9-羟基十八酸
A hydroxy fatty acid
GC48982 CD532 An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
GC48974 Ac-VEID-AMC (ammonium acetate salt)
NAcetylValGluIleAsp7amido4Methylcoumarin, Caspase6 Substrate (Fluorogenic)
A caspase-6 fluorogenic substrate
GC48971 AZD 1152 (hydrochloride)
5-[[7-[3-[乙基[2-(磷酰氧基)乙基]氨基]丙氧基]-4-喹唑啉基]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺二盐酸盐
A prodrug for a potent Aurora B inhibitor
GC48969 Withanone
NSC 179884
A phytochemical with diverse biological activities
GC48968 Docetaxel (hydrate)
多烯紫杉醇三水合物(非药典标准品)
A microtubule-stabilizing agent
GC62711 BAMEA-O16B BAMEA-O16B 是一种脂质纳米颗粒。BAMEA-O16B 结合了二硫键，可以有效地将 Cas9 mRNA 和 sgRNA 传递到细胞中，同时响应细胞内还原环境释放 RNA 进行基因组编辑。BAMEA-O16B 可用于基因编辑的研究。
GC62697 ZN-c3 ZN-c3 is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.
GC62657 MRIA9 MRIA9 是 ATP 竞争性的、pan-SIK 和 PAK2/3 抑制剂，其对 SIK1、SIK2 和 SIK3 的 IC50 值分别为 516 nM, 180 nM 和 127 nM。
GC62594 hnRNPK-IN-1 hnRNPK-IN-1 是一种异质核糖核蛋白 K (hnRNPK) 结合配体，用 SPR 和 MST 测量的 Kd 值分别为 4.6 μM 和 2.6 μM。hnRNPK-IN-1 通过破坏 hnRNPK 和 c-myc 启动子的结合来抑制 c-myc 转录。hnRNPK-IN-1诱导 Hela 细胞凋亡 (apoptosis)，并具有很强的抗肿瘤活性。
GC62482 TAS-119 TAS-119 是一种有效的，选择性的，具有口服活性的 Aurora A 抑制剂，IC50 为 1.0 nM。TAS-119 对 Aurora A 的选择性高于其他蛋白激酶，包括 Aurora B (IC50 为 95 nM)。TAS-119 具有有效的抗肿瘤活性。
GC62449 WEE1-IN-3 WEE1-IN-3 是一种有效的 Wee1 激酶抑制剂，其 IC50 <10 nM。WEE1-IN-3 具有抗癌活性。
GC62443 ErSO ErSO activates the anticipatory unfolded protein response (a-UPR) with an IC50 of 20.3 nM in MCF-7 cells. ErSO induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro.
GC62433 AKI603 AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation.
GC62383 (±)-ErSO (±)-ErSO 是 ErSO 的消旋体。ErSO 是选择性预期未折叠蛋白反应 (a-UPR) 激活物。
GC62287 EN4 EN4, a covalent ligand that targets cysteine 171 (C171) of MYC, is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.
GC62205 Maytansine
美坦新,NSC 153858
An ansa macrolide with anticancer activity
GC62189 CD532 hydrochloride An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
GC62174 ON1231320 ON1231320 (7ao), an arylsulfonyl pyrido-pyrimidinone, is a highly specific inhibitor of polo like kinase 2 (PLK2). It also blocks tumor cell cycle progression in the G2/M phase in mitosis and causes apoptosis.
GC62145 Chiauranib
CS2164
Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
GC62128 Bractoppin Bractoppin 是一种串联 BRCT（串联 BRCT，BRCA1），由人乳腺癌和卵巢癌抑制蛋白 (BRCA1) tBRCT 结构域识别磷酸肽的药物样抑制剂，在体外选择性抑制底物结合的纳摩尔活性，IC50 为0.074 77777#181;M。
GC62108 Elimusertib hydrochloride
BAY 1895344 hydrochloride
Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂，IC50 值为 7 nM，具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。
GC19822 SYRINGETIN
丁香亭
丁香素是一种类黄酮衍生物，与 BMP-2 产量增加有关。
GC61995 PKCβ inhibitor 1
3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
A PKCβ Inhibitor
GC19773 Direct Red 80
天狼猩红; Sirius Red

直接红80
GC61870 NY2267 NY2267 是一种 Myc-Max 相互作用 (Myc-Max interaction) 干扰物，其 IC50 值为 36.5 µM。
GC61831 Benproperine phosphate
磷酸苯丙哌林
An antitussive agent and ARPC2 inhibitor
GC19762 Capsanthin (75%)
辣椒红
A carotenoid with diverse biological activities