Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC48968 Docetaxel (hydrate)
多烯紫杉醇三水合物(非药典标准品)
A microtubule-stabilizing agent
GC62711 BAMEA-O16B BAMEA-O16B 是一种脂质纳米颗粒。BAMEA-O16B 结合了二硫键，可以有效地将 Cas9 mRNA 和 sgRNA 传递到细胞中，同时响应细胞内还原环境释放 RNA 进行基因组编辑。BAMEA-O16B 可用于基因编辑的研究。
GC62697 ZN-c3 ZN-c3 is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.
GC62657 MRIA9 MRIA9 是 ATP 竞争性的、pan-SIK 和 PAK2/3 抑制剂，其对 SIK1、SIK2 和 SIK3 的 IC50 值分别为 516 nM, 180 nM 和 127 nM。
GC62594 hnRNPK-IN-1 hnRNPK-IN-1 是一种异质核糖核蛋白 K (hnRNPK) 结合配体，用 SPR 和 MST 测量的 Kd 值分别为 4.6 μM 和 2.6 μM。hnRNPK-IN-1 通过破坏 hnRNPK 和 c-myc 启动子的结合来抑制 c-myc 转录。hnRNPK-IN-1诱导 Hela 细胞凋亡 (apoptosis)，并具有很强的抗肿瘤活性。
GC62482 TAS-119 TAS-119 是一种有效的，选择性的，具有口服活性的 Aurora A 抑制剂，IC50 为 1.0 nM。TAS-119 对 Aurora A 的选择性高于其他蛋白激酶，包括 Aurora B (IC50 为 95 nM)。TAS-119 具有有效的抗肿瘤活性。
GC62449 WEE1-IN-3 WEE1-IN-3 是一种有效的 Wee1 激酶抑制剂，其 IC50 <10 nM。WEE1-IN-3 具有抗癌活性。
GC62443 ErSO ErSO activates the anticipatory unfolded protein response (a-UPR) with an IC50 of 20.3 nM in MCF-7 cells. ErSO induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro.
GC62433 AKI603 AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation.
GC62383 (±)-ErSO (±)-ErSO 是 ErSO 的消旋体。ErSO 是选择性预期未折叠蛋白反应 (a-UPR) 激活物。
GC62287 EN4 EN4, a covalent ligand that targets cysteine 171 (C171) of MYC, is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.
GC62205 Maytansine
美坦新,NSC 153858
An ansa macrolide with anticancer activity
GC62189 CD532 hydrochloride An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
GC62174 ON1231320 ON1231320 (7ao), an arylsulfonyl pyrido-pyrimidinone, is a highly specific inhibitor of polo like kinase 2 (PLK2). It also blocks tumor cell cycle progression in the G2/M phase in mitosis and causes apoptosis.
GC62145 Chiauranib
CS2164
Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
GC62128 Bractoppin Bractoppin 是一种串联 BRCT（串联 BRCT，BRCA1），由人乳腺癌和卵巢癌抑制蛋白 (BRCA1) tBRCT 结构域识别磷酸肽的药物样抑制剂，在体外选择性抑制底物结合的纳摩尔活性，IC50 为0.074 77777#181;M。
GC62108 Elimusertib hydrochloride
BAY 1895344 hydrochloride
Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂，IC50 值为 7 nM，具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。
GC19822 SYRINGETIN
丁香亭
丁香素是一种类黄酮衍生物，与 BMP-2 产量增加有关。
GC61995 PKCβ inhibitor 1
3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
A PKCβ Inhibitor
GC19773 Direct Red 80
天狼猩红; Sirius Red

直接红80
GC61870 NY2267 NY2267 是一种 Myc-Max 相互作用 (Myc-Max interaction) 干扰物，其 IC50 值为 36.5 µM。
GC61831 Benproperine phosphate
磷酸苯丙哌林
An antitussive agent and ARPC2 inhibitor
GC19762 Capsanthin (75%)
辣椒红
A carotenoid with diverse biological activities
GC61584 Vinflunine ditartrate
酒石酸长春氟宁

Vinflunineditartrate是一种长春花生物碱家族的氟化微管抑制剂。Vinflunineditartrate具有抗血管生成，破坏血管和抗转移的活性。Vinflunineditartrate可用于尿路上皮移行细胞癌，非小细胞肺癌和乳腺癌的研究。
GC61400 MAP4343 MAP4343是Pregnenolone的3-甲基醚衍生物。MAP4343在体外与微管相关蛋白2(MAP2)结合，刺激微管蛋白的聚合，增强神经突的延伸并保护神经元免受神经毒性剂的侵害。
GC19528 1,4-Benzoquinone
对苯醌
A toxic metabolite of benzene
GC48901 BRD9876
6-叔丁基-2,3-二氰基萘
An Eg5 inhibitor
GC48848 Albendazole-d7
阿苯达唑-D7,SKF-62979-d7
An internal standard for the quantification of albendazole
GC48764 Sydowinin B
MS-347b
A xanthone polyketide with immunosuppressant activity
GC48721 6-O-Demethyl Griseofulvin
6-Demethylgriseofulvin
A metabolite of griseofulvin
GC48720 Griseofulvic Acid
(±)-Griseofulvic Acid
A metabolite of griseofulvin
GC48688 Griseofulvin-d3
灰黄霉素 d3
An internal standard for the quantification of griseofulvin
GC48659 Umbelliprenin
7-Farnesyloxycoumarin
A prenylated coumarin with diverse biological activities
GC48652 Olomoucine II
2-[[[2-[[(1R)-1-(羟基甲基)丙基]氨基]-9-(1-甲基乙基)-9H-嘌呤-6-基]氨基]甲基]苯酚
A CDK inhibitor
GC48509 Apigenin 7-O-Glucuronide (hydrate) Apigenin 7-O-glucuronide is a flavonoid that has been found in J
GC48471 Z-(L-Arg)-AMC (hydrochloride)
Z-L-精氨酸-7-胺基-4-甲基香豆素盐酸盐
A fluorogenic substrate for trypsin, cathepsin B, and cathepsin H
GC48470 Ac-DEVD-CHO (trifluoroacetate salt)
N-Ac-Asp-Glu-Val-Asp-CHO
A dual caspase-3/caspase-7 inhibitor
GC48430 Ac-DEVD-CMK (trifluoroacetate salt)
AcAspGluValAspCMK, Caspase3 Inhibitor III
An inhibitor of caspase-3
GC48423 19-O-Acetylchaetoglobosin A
Chaetoglobosin A Acetate
A fungal metabolite with actin polymerization inhibitory and cytotoxic activities
GC48401 Risuteganib (trifluoroacetate salt)
ALG-1001
An anti-integrin peptide
GC48394 Phomopsinamine
Phomopsinamine A
An inhibitor of microtubule polymerization
GC48390 Z-LRGG-AMC (trifluoroacetate salt)
Z-Leu-Arg-Gly-Gly-AMC, Z-Leu-Arg-Gly-Gly-7-amino-4-methylcoumarin
A fluorogenic substrate for isopeptidase T
GC48387 Inostamycin A A bacterial metabolite with anticancer activity
GC48200 Trelagliptin-13C-d3 A neuropeptide with diverse biological activities
GC48174 Thiorphan-d5 An internal standard for the quantification of thiorphan
GC48120 T-2 Toxin-13C24
Fusariotoxin T-2-13C24, Insariotoxin-13C24, Mycotoxin T-2-13C24
A neuropeptide with diverse biological activities
GC48119 Suprafenacine
SML1493
An inhibitor of tubulin polymerization with anticancer activity
GC48101 SSAA09E1 A SARS-CoV entry inhibitor
GC48092 Spinosad
LY232105, XDE-105
A naturally-occurring insecticide
GC48090 Sphingosine-d9 (d18:1)
D-erythro-Sphingosine C18-d9
A neuropeptide with diverse biological activities