Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC46434 13C15-Nivalenol An internal standard for the quantification of nivalenol
GC46385 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-Mannopyranose
1,3,4,6-四-O-乙酰基-2-叠氮基-2-脱氧-Α-D-吡喃甘露糖
A ManNAc analog and building block
GC46379 1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)
1,2-二-(9Z-十八碳烯酰基)-sn-甘油-3-磷酰-L-丝氨酸钠盐
A phospholipid
GC46351 (S)-CR8 An inhibitor of cyclin-dependent kinases
GC46347 (S)-(+)-Methoprene
S-(+)-烯虫酯,(+)-Methoprene; (7S)-Methoprene
An insect growth regulator and Met agonist
GC46335 (E)-Fenpyroximate
唑螨酯
A phenoxypyrazole acaricide
GC46308 (±)-Sitagliptin-d4 (hydrochloride) A neuropeptide with diverse biological activities
GC61314 Taltobulin hydrochloride
HTI-286 hydrochloride; SPA-110 hydrochloride
Taltobulinhydrochloride(HTI-286hydrochloride)是一种合成的三肽半胱氨酸类似物，Taltobulin是一种有效的抗微管剂(antimicrotubule)，可在体内外规避P-糖蛋白介导的耐药性。Taltobulinhydrochloride抑制纯化的微管蛋白聚合，破坏细胞中的微管组织，并诱导有丝分裂停滞以及凋亡(apoptosis)。
GC61286 SP-8356 SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.
GC61072 MK-28 MK-28是有效、选择性的PERK激动剂。MK-28在小鼠中表现出良好的药代动力学特征，且能透过血脑屏障。
GC61043 Mesalamine impurity P
美沙拉嗪EP杂质P
MesalamineimpurityP是Mesalamine的杂质。5-Aminosalicylicacid(Mesalamine)是一种特异性的 PPARγ 激动剂，还抑制p21-激活激酶1(PAK1)和 NF-κB。
GC61014 Lusianthridin
4,7-二羟基-2-甲氧基-9,10-二氢菲
Lusianthridin是来自Dendrobiumvenustum的天然化合物，具有抗迁移作用。Lusianthridin通过抑制Src-STAT3信号，促进c-Myc的降解。
GC60891 GW406108X
GW108X
GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
GC60871 Gemigliptin tartrate
吉格列汀酒石酸盐,LC15-0444 tartrate
A DPP-4 inhibitor
GC60688 Cereblon modulator 1
CC-90009
A modulator of cereblon
GC60628 BD750 BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
GC60621 Batabulin sodium
T138067 sodium
An inhibitor of tubulin polymerization
GC60620 Batabulin
巴他布林; T138067
An inhibitor of tubulin polymerization
GC60376 UC2288 UC2288 is a novel, cell-permeable, and orally active p21 attenuator, decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability.
GC60311 PTUPB PTUPB是一种新型的COX-2和sEH双抑制剂，IC₅₀ 值分别为 1.26 nM 和 0.9μM。
GC60294 Poloppin Poloppin是一种有效的细胞渗透抑制剂，可抑制有丝分裂的polo样激酶(PLK)IC50=26.9μM)，并可通过Polo-box结构域(PBD)阻止蛋白之间的相互作用(Kd=29.5μM)。Poloppin选择性地杀死表达突变KRAS的细胞，增强有丝分裂中的死亡。Poloppin可用作KRAS突变型癌症的研究，可作为单一试剂，或与c-MET抑制剂联合使用。
GC60259 MYCMI-6
NSC354961
MYCMI-6 (NSC354961) 是一种有效的选择性内源性 MYC:MAX 蛋白相互作用抑制剂。 MYCMI-6 阻断 MYC 驱动的转录。MYCMI-6 选择性结合 MYC bHLHZip 域，Kd 值为 1.6 μM。MYCMI-6 以 MYC 依赖性的方式抑制肿瘤细胞的生长 (IC50<0.5 μM)。MYCMI-6 对正常人细胞无细胞毒性。MYCMI-6 诱导细胞凋亡 (apoptosis)。
GC60143 DM3
Maytansinoid DM3
DM3 (Maytansinoid DM3) 是一种带有二硫键或硫醇基的美登素类似物，是一种 tubulin 的抑制剂，还是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分。
GC60120 Danicamtiv
MYK-491
A cardiac-specific myosin activator
GC39810 CID44216842
Cdc42-IN-1
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively.
GC39798 Scoulerine
金黄紫堇碱,(-)-Scoulerine; Discretamine
A benzylisoquinoline alkaloid with diverse biological activities
GC39558 Tubulin inhibitor 6
Improved Heterocyclic Activator of PP2A 1, Tubulin Inhibitor 6
An inhibitor of tubulin polymerization and a PP2A activator
GC39486 DCLK1-IN-1 DCLK1-IN-1 is a selective, in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1) domain that binds to DCLK1 and DCLK2 with IC50 of 9.5 nM and 31 nM, respectively. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases with IC50 of 57.2 nM and 103 nM in kinase assay, respectively.
GC39483 BO-264 A TACC3 inhibitor
GC50599 P110 Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
GC50574 MB 0223 Dynamin-related GTPase DRP1 partial inhibitor
GC50529 Surfen
Aminoquincarbamide dihydrochloride
Surfen 是一种有效的 HS（硫酸乙酰肝素）拮抗剂。
GC50439 Peptide5 Peptide5 是一种连接蛋白 43 模拟肽，可减少脊髓损伤后动物肿胀、星形胶质细胞增生和神经元细胞死亡体外:Peptide5 显着降低啮齿动物离体模型中的脊髓损伤 (SCI) 程度。
GC50424 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable
GC50397 Flutax 2 绿色荧光紫杉醇衍生物；结合微管
GC50370 AZ 13705339 AZ 13705339 是一种高效的选择性 PAK1 抑制剂，对 PAK1 和 pPAK1 的 IC50 分别为 0.33 nM 和 59 nM。 AZ 13705339 与 PAK1 和 PAK2 具有结合亲和力，Kds 分别为 0.28 nM 和 0.32 nM。 AZ 13705339 可用于癌症研究。
GC50314 PF 3758309 dihydrochloride
PF-03758309 dihydrochloride
An inhibitor of PAK4
GC50214 LCB 03-0110 dihydrochloride Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
GC50175 CGP 74514 dihydrochloride Potent cdk1 inhibitor
GC50145 CHR 6494 trifluoroacetate A selective Haspin protein kinase inhibitor
GC50116 OXA 06 dihydrochloride Potent ROCK inhibitor
GC50110 Mps1-IN-1 dihydrochloride A selective Mps1 kinase inhibitor
GC50092 RKI 1447 dihydrochloride A ROCK1 and ROCK2 inhibitor
GC50056 UA 62784 Inhibits microtubule polymerization
GC50052 Laulimalide
Microtubule stabilzing agent
GC50050 Hesperadin hydrochloride A multi-kinase inhibitor
GC50045 PD 166285 dihydrochloride
6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
A tyrosine kinase inhibitor
GC50043 SR 3677 dihydrochloride A ROCK1 and ROCK2 inhibitor
GC50020 Dynamin inhibitory peptide, myristoylated DynaMin inhibitory peptide, myristoylated 是一种 DynaMin 抑制剂，可干扰两性霉素与 dynamin 的结合。
GC39209 LCH-7749944
GNF-PF-2356
LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4.