Mps1(单极纺锤体1激酶)

MPS1 (monopolar spindle 1 kinase) is a crucial part of the spindle assembly checkpoint. It facilitates the formation of C-MAD2 (closed MAD2) conformer and the MCC (mitotic checkpoint complex) assembly, and involved in the tumor growth.

Products for Mps1

Cat.No. 产品名称 Information
GC65339 Mps1-IN-3 hydrochloride Mps1-IN-3 hydrochloride 是一种有效且具有选择性的 Mps1 抑制剂，IC50 为 50 nM。Mps1-IN-3 hydrochloride 可抑制胶质母细胞瘤细胞的增殖，并在原位异种移植瘤模型中能有效地使胶质母细胞瘤对长春新碱敏感。
GC50110 Mps1-IN-1 dihydrochloride A selective Mps1 kinase inhibitor
GC36752 NMS-P715 An Mps1/TTK inhibitor
GC36651 Mps1-IN-3 Mps1-IN-3 是一种有效的，选择性的 MPS1 抑制剂，IC50 值为 50 nM。
GC34073 Empesertib (BAY 1161909)
BAY 1161909
Empesertib (BAY1161909, Mps1-IN-5), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib has potential antineoplastic activity.
GC33213 CCT251455 CCT251455是有效和选择性的有丝分裂激酶单极纺锤体1(MPS1)抑制剂，IC50值为3nM。
GC32846 BOS-172722 BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.
GC19058 BAY1217389 An orally bioavailable inhibitor of Mps1
GC11292 Mps1-IN-1
Monopolar Spindle 1 Kinase Inhibitor 1, Mps1 Kinase Inhibitor 1
A selective Mps1 kinase inhibitor
GC13727 TC Mps1 12 TC Mps1 12 是一种有效的选择性单极纺锤体 1 (Mps1) 抑制剂，IC50 为 6.4 nM。
GC10083 MPI-0479605 A potent inhibitor of MPS1
GC15745 Mps1-IN-2
9-环戊基-2-[[2-乙氧基-4-(4-羟基哌啶-1-基)苯基]氨基]-5-甲基-8,9-二氢-5H-嘧啶并[4,5-B][1,4]二氮杂卓-6(7H)-酮
An inhibitor of Mps1
GC15283 AZ3146
AZ 3146; AZ-3146
A selective inhibitor of the spindle checkpoint kinase Mps1