ROCK(Rho相关蛋白激酶)

ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC family of serine-threonine kinases and takes part in regulating the shape and movement of cells by acting on the cytoskeleton.

Products for ROCK

Cat.No. 产品名称 Information
GC16475 Afuresertib
GSK2110183
A pan-Akt inhibitor
GC12817 K-115 hydrochloride dihydrate
(2S)-1-[(4-氟-5-异喹啉基)磺酰基]六氢-2-甲基-1H-1,4-二氮杂卓单盐酸盐二水合物,K-115
K-115 hydrochloride dihydrate (K-115) 是 ROCK 的特异性抑制剂，对 ROCK2 和 ROCK1 的 IC50 分别为 19 和 51 nM。
GC15170 SB 772077B dihydrochloride A ROCK1 and ROCK2 inhibitor
GC17712 AT13148 A multi-AGC kinase inhibitor
GC13869 Fasudil
法舒地尔; HA-1077; AT877
Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K_i为0.33μM，IC₅₀为0.158μM，对ROCK2和PKA、PKC、PKG的IC₅₀分别为4.58μM、12.30μM、1.650μM。
GC17936 GSK269962A
N-[3-[[2-(4-氨基呋咱-3-基)-1-乙基-1H-咪唑并[4,5-C]吡啶-6-基]氧]苯基]-4-[[2-(4-吗啉基)乙基]氧]苯甲酰胺,GSK 269962
A ROCK1 and ROCK2 inhibitor
GC10722 SR-3677
N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
A ROCK1 and ROCK2 inhibitor
GC15712 Y-27632 A ROCK inhibitor
GC13423 Y-39983 dihydrochloride ROCK family inhibitor
GC14289 Fasudil (HA-1077) HCl
盐酸法舒地尔; HA-1077 Hydrochloride; AT-877 Hydrochloride
Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K_i为0.33μM，IC₅₀为0.158μM，对ROCK2和PKA、PKC、PKG的IC₅₀分别为4.58μM、12.30μM、1.650μM。
GC18119 GSK429286A
N-(6-氟-1H-吲唑-5-基)-2-甲基-6-氧代-4-[4-(三氟甲基)苯基]-1,4,5,6-四氢-3-吡啶甲酰胺
A ROCK inhibitor
GC11181 Thiazovivin
Tzv
A ROCK inhibitor
GC12827 SLx-2119
2-[3-[4-[(1H-吲唑-5-基)氨基]喹唑啉-2-基]苯氧基]-N-异丙基乙酰胺,SLx 2119;SLx2119;ROCK inhibitor;KD-025
A ROCK2 inhibitor
GC15437 RKI-1447
RKI 1447;RKI1447
A ROCK1 and ROCK2 inhibitor
GC12491 Narciclasine
水仙环素; Lycoricidinol
A plant growth regulator with anticancer activity
GC10338 Hydroxyfasudil hydrochloride
羟基法舒地尔盐酸盐; HA-1100 hydrochloride; HA 1100 hydrochloride; HA1100 hydrochloride
A ROCK inhibitor
GC10901 Hydroxyfasudil
羟基法舒地尔; HA-1100
Hydroxyfasudil 是一种 ROCK 抑制剂，对 ROCK1 和 ROCK2 的 IC50 分别为 0.73 和 0.72 μM。
GC16097 Chroman 1
(3S)-N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-3,4-二氢-6-甲氧基-2H-1-苯并吡喃-3-甲酰胺,ROCK-II inhibitor
A ROCK2 inhibitor
GC10512 Y-27632 dihydrochloride
y-27632, Y27632, Y-27632 dihydrochloride, Y 27632
Y-27632 dihydrochloride 作为一种选择性 Rho 激酶抑制剂，是一种新型支气管扩张剂。