DNA Damage/DNA Repair(DNA损伤/DNA修复)

Cat.No. 产品名称 Information

GC38899 CDK ligand for PROTAC hydrochloride CDK ligand for PROTAC hydrochloride 是一种具有抗肿瘤活性的 CDK 抑制剂。CDK ligand for PROTAC hydrochloride 和 CRBN 配体可用于设计 PROTAC CDK4/6 降解剂。

GC38896 Caracemide

卡醋胺,NSC-253272

Caracemide (NSC-253272) 可以抑制大肠杆菌的核糖核苷酸还原酶。Caracemide是衍生自异羟肟酸的新型抗癌药，会产生严重的中枢神经系统 (CNS) 毒性。

GC46033 5-Heneicosylresorcinol

5-二十一烷基间苯二酚,5-Heneicosylresorcinol

An alkylresorcinol

GC45998 Mitoxantrone-d8

米托蒽醌-D8,Mitozantrone-d8; NSC 301739-d8

An internal standard for the quantification of mitoxantrone

GC45983 Voruciclib A pan-CDK inhibitor

GC38860 TH-257 An inhibitor of LIMK1 and LIMK2

GC38858 Telomerase-IN-2 Telomerase-IN-2 是一种端粒酶 (telomerase) 抑制剂，通过降低角化不良蛋白的表达来抑制其活性，IC50 值为 0.89 µM。Telomerase-IN-2 具有抗癌作用。

GC38774 DRF-1042 DRF-1042 是一种具有口服活性的喜树碱类似物，具有抑制 DNA 拓扑异构酶 I (DNA topoisomerase I) 的作用。DRF-1042 对一组人癌细胞株，包括多药耐药 (MDR)表型，显示出良好的抗癌活性。

GC38755 CKI-7 A CK1 inhibitor

GC38749 Abemaciclib metabolite M20

LSN3106726

Abemaciclib metabolite M20 是 Abemaciclib 的活性代谢物，是一种选择性 CDK4/6 抑制剂，可用于癌症的相关研究

GC38742 BRD-6929

JQ12

An HDAC1 and HDAC2 inhibitor

GC38737 AS2863619 free base A dual inhibitor of Cdk8 and Cdk19

GC38736 AS2863619 A dual inhibitor of Cdk8 and Cdk19

GC45906 MC1742 An inhibitor of class I and class IIb HDACs

GC45888 Topotecan-d6

(4S)-10-[[二(三氘甲基)氨基]甲基]-4-乙基-4,9-二羟基-1H-吡喃并[3',4':6,7]吲哚嗪并[1,2-B]喹啉-3,14(4H,12H)-二酮

An internal standard for the quantification of topotecan

GC45886 Levofloxacin-d8 (hydrochloride) A neuropeptide with diverse biological activities

GC45820 Balsalazide-d4 Balsalazide-d4 是氘标记的 Balsalazide。

GC45808 OUL35

NSC39047

An inhibitor of PARP10

GC45800 Cytarabine-13C3

Ara-C-13C3, 1-β-D-Arabinofuranosylcytosine-13C3

A neuropeptide with diverse biological activities

GC45772 6(5H)-Phenanthridinone

6(5H)-菲啶酮

An inhibitor of PARP1 and 2

GC45717 Chlamydocin An HDAC inhibitor

GC38518 AMG-548 dihydrochloride An inhibitor of p38α MAPK

GC38511 Groenlandicine

格兰地新

Groenlandicine 是从黄连中分离得到的一种原小檗碱生物碱。Groenlandicine 对人类重组醛糖还原酶 (HRAR) 具有中度的抑制作用，IC50 值为 154.2 μM。Groenlandicine 能诱导拓扑异构酶 I (topoisomerase I) 介导的 DNA 裂解。

GC38482 Desmethylglycitein

4',6,7-三羟基异黄酮; 4',6,7-Trihydroxyisoflavone

An active metabolite of daidzein

GC38466 Pseudouridimycin

PUM

Pseudouridimycin (PUM) 是一种抗生素，选择性细菌 RNA 聚合酶 (RNAP) 抑制剂。Pseudouridimycin 是一种 C-核苷类似物，对革兰氏阴性菌和革兰氏阳性菌均有效。

GC38463 ASLAN003

ASLAN003

A DHODH inhibitor

GC38412 Crotonoside

巴豆苷; Isoguanosine

Crotonoside是一种FLT3和HDAC3/6抑制剂，可用于研究急性髓系白血病(AML)。

GC38392 Euscaphic acid

野鸦椿酸

A triterpene with diverse biological activities

GC38382 CNDAC hydrochloride CNDAC hydrochloride 是可口服试剂 sapacitabine 的代谢物，为核苷酸类似物。

GC38377 (2S,3R)-Voruciclib hydrochloride (2S,3R)-Voruciclib hydrochloride 是 Voruciclib hydrochloride 的低活性异构体。Voruciclib hydrochloride 是一种 CDK9 抑制剂。

GC38354 Seco-Duocarmycin TM Seco-Duocarmycin TM 是 Duocarmycins 家族的一种 DNA 烷化剂，可抑制 DNA 合成。Seco-Duocarmycin TM 是一种细胞毒性剂，用作抗体-药物偶联物中的细胞毒性成分。

GC38349 Seco-Duocarmycin SA Seco-Duocarmycin SA 是一种高效的 DNA 烷化剂 (DNA alkylator)，可作用做抗体-药物偶联物 (ADC) 的毒素部分。

GC38330 EHT 5372 EHT 5372 是双特异性酪氨酸磷酸化调节酶 (DYRK) 的强效抑制剂，其 IC50 值分别为 0.22，0.28 nM。

GC38202 DTP3 TFA DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.

GC38201 Metarrestin

ML246

Metarrestin (ML246) is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models.

GC38194 (±)-10-Hydroxycamptothecin

10-羟基喜树碱,(±)-10-HCPT

Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.