DNA Damage/DNA Repair(DNA损伤/DNA修复)

Cat.No. 产品名称 Information

GC48372 Erythromycin 2'-Propionate

红霉素丙酸酯

An antibiotic

GC48365 Bottromycin A2 An antibiotic

GC50719 FMF-04-159-R Potent inhibitor of CDK16 and CDK14 (IC50 values are 6 and 140 nM, respectively in kinase activity assay; IC50 = 563 nM for CDK14 in BRET assay)

GC50656 BAY 707 BAY 707 是一种底物竞争性、高效和选择性的 MTH1(NUDT1) 抑制剂，IC50 为 2.3 nM。 BAY 707 与其他 MTH1 化合物相比具有良好的药代动力学 (PK) 特征，并且在小鼠中具有良好的耐受性，但明显缺乏体外或体内抗癌功效。

GC19566 N-Nitrosodiethylamine (950mg/mL)

N-亚硝基二乙胺 ;N-二乙基亚硝胺

N-Nitrosodiethylamine (Diethylnitrosamine) 是一种有效的肝癌致癌二烷基亚硝胺。 N-亚硝基二乙胺主要存在于烟草烟雾、水、切达奶酪、腌制食品、油炸食品和许多酒精饮料中。 N-亚硝基二乙胺负责与 DNA 修复/复制相关的核酶的变化。 N-亚硝基二乙胺在所有动物物种中导致各种肿瘤。主要靶器官为鼻腔、气管、肺、食道和肝脏。

GC48190 TP-4748 A heterocyclic building block

GC48165 Thiocoraline

PM 93135

A depsipeptide and DNA bis-intercalator with antibacterial and anticancer activities

GC48141 Temozolomide-d3

替莫唑胺 d3

An internal standard for the quantification of temozolomide

GC48120 T-2 Toxin-13C24

Fusariotoxin T-2-13C24, Insariotoxin-13C24, Mycotoxin T-2-13C24

A neuropeptide with diverse biological activities

GC48118 Sunitinib-d10

舒尼替尼-D10,SU 11248-d10

An internal standard for the quantification of sunitinib

GC47933 Pemetrexed-13C5 (sodium salt hydrate) A neuropeptide with diverse biological activities

GC47817 Olaparib-d4 A neuropeptide with diverse biological activities

GC47693 m-Methoxybenzamide

3-甲氧基苯甲酰胺,3-MBA

A PARP inhibitor

GC47552 Leflunomide-d4

来氟米特 d4

An internal standard for the quantification of leflunomide

GC47521 K22 An antiviral agent

GC47276 D-threo-PPMP (hydrochloride)

D-threo-1-phenyl-2-Palmitoylamino-3-morpholino-1-propanol

A GlyCer synthetase inhibitor

GC47167 Dacarbazine-d6

达卡巴嗪-D6,Imidazole Carboxamide-d6

An internal standard for the quantification of dacarbazine

GC47162 Cytidine 5'-triphosphate (sodium salt hydrate)

胞嘧啶核苷5`-三磷酸二钠盐水合物

A pyrimidine nucleoside triphosphate

GC47148 Cyclophosphamide-d4

环磷酰胺 d4

An internal standard for the quantification of cyclophosphamide

GC47098 CL2-SN-38 (dichloroacetic acid salt) An antibody-drug conjugate containing SN-38

GC47078 Chlorambucil-d8

CB-1348-d8; WR-139013-d8

苯丁酸氮芥 (CB-1348-d8) 是氘标记的苯丁酸氮芥。苯丁酸氮芥 (CB-1348) 是一种具有口服活性的抗肿瘤剂，是一种属于氮芥类的双功能烷化剂。苯丁酸氮芥可用于淋巴细胞白血病、卵巢癌和乳腺癌以及霍奇金病的研究。

GC47059 CAY10760 An inhibitor of the RAD51-BRCA2 interaction

GC47056 CAY10753 A TNKS2 inhibitor

GC47055 CAY10749 A dual inhibitor of PARP and PI3K

GC46962 Busulfan-d8

白消安 d8

An internal standard for the quantification of busulfan

GC46914 Bendamustine-d4 (hydrochloride)

盐酸苯达莫司汀 d4 (盐酸盐)

A neuropeptide with diverse biological activities

GC46900 AZ9482 A PARP inhibitor

GC46895 Aurintricarboxylic Acid (ammonium salt)

铝试剂

A protein synthesis inhibitor with diverse biological activities

GC46880 ARN24139 A topoisomerase II poison

GC46814 Aflatoxin M1-13C17

AFM1-13C17

A neuropeptide with diverse biological activities

GC46810 Aflatoxin B1-13C17

黄曲霉毒素B1-(全碳-13)

An internal standard for the quantification of aflatoxin B₁

GC46806 Adenosine 5'-diphosphate (potassium salt hydrate)

5'-ADP, ADP

A neuropeptide with diverse biological activities

GC46744 8-Bromoadenosine 5′-triphosphate (sodium salt hydrate)

8-bromo ATP

A neuropeptide with diverse biological activities

GC46733 7,12-Dimethylbenz[a]anthracene

9,10-二甲基-1,2-苯并蒽；DMBA

7,12-Dimethylbenz[a]anthracene是一种免疫抑制剂，也是一种强效的器官特异性致癌物。

GC46713 5-Phospho-D-ribose 1-diphosphate (sodium salt hydrate)

Phosphoribosyl Pyrophosphate, P-rib-PP, PRPP

An intermediate in several biochemical pathways

GC46681 5-Bromouridine

5-溴尿苷

A brominated uridine analog

GC46607 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

4-甲基亚硝胺基-1-3-吡啶基-1-丁酮(NNK),NNK

A tobacco-specific nitrosamine carcinogen

GC46540 2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate) A purine nucleotide

GC46524 2,6-Dichloropurine-9-β-D-riboside

2,6-二氯嘌呤核苷

A building block

GC46519 2',3'-O-Isopropylideneguanosine

2',3'-O-异丙亚基鸟苷

A building block

GC46508 2',2'-Difluoro-2'-deoxyuridine

2'-脱氧-2',2'-二氟尿嘧啶核苷

An active metabolite of gemcitabine

GC46474 18-Deoxyherboxidiene

RQN-18690A

A bacterial metabolite with antiangiogenic activity

GC61359 TTP-8307 TTP-8307是几种鼻和肠道病毒(rhino-/enteroviruses)复制的有效抑制剂。TTP-8307通过干扰病毒RNA的合成抑制coxsackievirusB3病毒(CVB3;EC50=1.2μM)和poliovirus病毒。TTP-8307通过氧化甾醇结合蛋白(OSBP)发挥抗病毒活性。

GC61348 Triazavirin

Riamilovir, TZV

An antiviral agent

GC61276 Silver sulfadiazine

磺胺嘧啶银,AgSD

Silver sulfadiazine is a bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast.

GC61246 Rifalazil

利福拉齐; KRM-1648; ABI-1648

Rifalazil(ABI-1648;KRM-1648)是利福霉素衍生物，可抑制细菌依赖DNA的RNA聚合酶(RNApolymerase)并阻断RNA聚合酶中的β亚基从而杀死细菌感染的细胞。Rifalazil(ABI-1648;KRM-1648)是一种抗生素(antibiotic)，对分枝杆菌，革兰氏阳性细菌，幽门螺杆菌，肺炎衣原体和沙眼衣原体有抑制作用，其MIC值在0.00025至0.0025μg/ml之间。Rifalazil(ABI-1648;KRM-1648)有潜力用于衣原体感染，梭菌相关性腹泻菌感染 (CDAD)和结核病(TB)研究的相关研究。

GC61224 Pyrazoloacridine

NSC366140无结构图,NSC 366140; PD 115934

Pyrazoloacridine(NSC366140)具有抗癌活性，抑制拓扑异构酶1和2的活性(topoisomerases1and2)。Pyrazoloacridine(NSC366140)对K562髓系白血病细胞中的IC50值为1.25μM(24h)。

GC61188 PIP-199

PIP-199是一种RecQ介导的基因组不稳定蛋白RMI核心复合物/MM2相互作用(RMIcorecomplex/MM2interaction)的选择性抑制剂，其IC50值为36μM。MM2是FANCM上RMI复合物的结合位点。PIP-199可用于耐受肿瘤对DNA交联化疗药物的增敏研究。

GC61182 Phosphoramide mustard (cyclohexanamine)

NSC 69945, PMC

An alkylating agent and active metabolite of cyclophosphamide

GC61168 Peldesine

BCX 34

Peldesine(BCX34)是一种有效的，竞争性，可逆和口服活性的嘌呤核苷磷酸化酶(PNP)抑制剂，对人，大鼠和小鼠红细胞(RBC)PNP的IC50分别为36nM，5nM和32nM。Peldesine还是一种T细胞(T-cell)增殖抑制剂，IC50为800nM。Peldesine可用于皮肤T细胞淋巴瘤，牛皮癣和HIV感染的研究。