DNA Damage/DNA Repair(DNA损伤/DNA修复)

Cat.No. 产品名称 Information

GC35022 [pThr3]-CDK5 Substrate [pThr3]-CDK5 Substrate 是有效的 Thr3 位点磷酸化的 CDK5 底物。[pThr3]-CDK5 Substrate 衍生自组蛋白 H1 肽序列，位于 CDK5 的活性位点。[pThr3]-CDK5 Substrate 被 CDK5 磷酸化，Km 为 6 μM。

GC35021 [pSer2, pSer5, pSer7]-CTD TFA [pSer2, pSer5, pSer7]-CTD (TFA) 是 CDK7 的一个底物，是 RNA 聚合酶 II 羧基端域 (CTD) 的 ser2、ser5 和 ser7 位点磷酸化的多肽。

GC34999 (S)-Ceralasertib

(S)-AZD6738

(S)-Ceralasertib 从专利 WO2011154737A1 中获取，化合物 II，IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂，具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善，并且消除 CYP3A4 时间依赖性抑制。

GC34956 (+)-CBI-CDPI2 (+)-CBI-CDPI2 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI2 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。

GC34955 (+)-CBI-CDPI1 (+)-CBI-CDPI1 是 CC-1065 功能增强的一种类似物。(+)-CBI-CDPI1 是一种 DNA 烷化剂。(+)-CBI-CDPI1 可用作抗体-药物偶联物 (ADCs) 中的毒素分子。

GC14858 Aldoxorubicin

INNO-206;Doxorubicin-EMCH;INNO 206

A prodrug form of doxorubicin

GC45141 Vedaprofen

维达洛芬,,Quadrisol; CERM 10202; PM 150

An NSAID used in animals

GC45116 UNC2170 (maleate) A 53BP1 antagonist

GC45057 TIQ-A A PARP1 inhibitor

GC45009 Temafloxacin

替马沙星,TMFX; TA-167 free acid; A-62254 free acid

A DNA topoisomerase inhibitor

GC44984 TAF 10 Peptide

TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)Associated Factor, TBPAssociated Factor 10, TAFII30

A peptide associated with RNA polymerase II activity

GC44983 T2AA (hydrochloride)

T2-amino Alcohol

An inhibitor of PCNA

GC44981 T-2 Toxin

T-2毒素(镰刀菌属),T-2 Mycotoxin

A trichothecene mycotoxin

GC44953 Sterigmatocystin

甾体半胱氨酸

甾体半胱氨酸是由曲霉属真菌产生的一种霉菌毒素。

GC44897 SL 01

N-苯氧基碳-L-苯丙氨酰甲基氯酮,SL-01

An inhibitor of SARS-CoV M^pro

GC44809 Rebeccamycin

蝴蝶霉素

A DNA topoisomerase I inhibitor

GC44685 Procaine (hydrochloride)

Novocaine

Procaine (hydrochloride) is an analytical reference standard categorized as a local anesthetic that is used as an adulterant.

GC44681 preQ1 (hydrochloride)

Pre-Queuosine 1

A precursor of queuosine

GC44651 Pixantrone (maleate)

马来酸匹衫琼; BBR 2778

A DNA topoisomerase II inhibitor

GC44612 PF-4800567 A selective CK1ε inhibitor

GC44591 Pemetrexed (sodium salt hydrate)

培美曲赛二钠七水合物,LY231514 disodium heptahydrate

An antifolate with anticancer activity

GC44438 Nogalamycin

诺拉霉素

An anthracycline with anticancer activity

GC44408 Nitrosobenzene

亚硝基苯

A spin trap

GC44348 N-desmethyl Bendamustine

盐酸苯达莫司汀乙酯水解杂质

An active metabolite of bendamustine

GC44251 MTIC

替莫唑胺代谢物- MTIC

A DNA alkylating agent

GC44243 Monohydroxy Melphalan (hydrochloride)

Hydroxymelphalan

A DNA alkylating agent

GC44200 Mitomycin A

丝裂霉素A

A bacterial metabolite

GC44094 LX7101 (hydrochloride) A LIMK and ROCK inhibitor

GC43798 Guanylyl Imidodiphosphate (lithium salt)

Gpp(NH)p lithium

A nonhydrolyzable GTP analog

GC43796 Guanosine 5′-triphosphate (sodium salt hydrate)

鸟苷-5'-三磷酸二钠盐三水合物

An energy substrate for protein synthesis and gluconeogenesis

GC43726 Gallotannin

单宁酸

单宁酸（Gallotannin；Tannic acid）是一种天然多酚化合物，已在各种植物中发现，具有抗氧化、抗炎、抗血管生成、抗病毒和抗肿瘤等生物活性。Gallotannin抑制DNA聚合酶α、β和κ的活性，IC₅₀值分别为13、130和30nM。

GC43618 Epiblastin A An inhibitor of CK1α, CK1δ, and CK1ε

GC43565 Doxorubicinol (hydrochloride)

13-Dihydroadriamycin hydrochloride

A doxorubicin metabolite

GC43351 Cylindrospermopsin

柱孢藻毒素

A cyanotoxin

GC43209 CB-1954

5-(1-氮杂环丙基)-2,4-二硝基苯甲酰胺,CB 1954

An antitumor prodrug

GC43175 CAY10574 A Cdk2-cyclin E and Cdk9 inhibitor

GC43111 C8 L-threo Ceramide (d18:1/8:0)

L-threo Cer(d18:1/8:0), L-threo Ceramide (d18:1/8:0), N-octanoyl-L-threo-Sphingosine

A bioactive sphingolipid

GC43109 C8 D-threo Ceramide (d18:1/8:0)

D-threo Cer(d18:1/8:0), D-threo Ceramide (d18:1/8:0), N-octanoyl-D-threo-Sphingosine

A bioactive sphingolipid

GC42978 Bromamphenicol A dibrominated derivative of chloramphenicol

GC42912 Becatecarin

NSC 655649; BMS 181176; BMY 27557

A water-soluble antineoplastic antibiotic

GC42789 Aminopterin

氨基蝶呤; 4-Aminofolic acid; APGA

A synthetic folic acid derivative

GC42783 Ametantrone

阿美蒽醌,NSC 196473; NSC 290813

An inhibitor of topoisomerase II

GC42765 Aldehyde Reactive Probe (trifluoroacetate salt)

ARP, O(Biotinylcarbazoylmethyl) Hydroxylamine

A biotinylated probe for detecting AP sites in damaged DNA

GC42734 Adenosine 5'-phosphosulfate (sodium salt)

APS

An ATP sulfurylase and APS Kinase inhibitor

GC42733 Adenosine 5'-monophosphate (sodium salt hydrate)

AMP钠盐

A central cellular nucleotide

GC42732 Adenosine 3',5'-diphosphate (sodium salt)

腺苷3`,5`-二磷酸钠盐

An adenine nucleotide containing two phosphate groups

GC42627 8-Hydroxyguanine (hydrochloride)

依达比星杂质2

Product of oxidative damage to DNA or RNA

GC42562 5-Methyl-2'-deoxycytidine

5-甲基-2'-脱氧胞苷,5-Methyldeoxycytidine

A pyrimidine nucleoside

GC42545 5-Fluorouracil-13C,15N2

5-FU-13C,15N2

An internal standard for the quantification of 5-fluorouracil

GC42474 4-Thiouridine

4-硫代尿苷

4-Thiouridine 4-硫脲(4sU)是核糖核苷类似物，可用于RNA分析和(m)RNA标记。