DNA Damage/DNA Repair(DNA损伤/DNA修复)

Cat.No. 产品名称 Information

GC42464 4-oxo-2-Nonenal

4-ONE

A lipid peroxidation product

GC42401 4-hydroperoxy Cyclophosphamide

培磷酰胺,4-OOH-CY

4-hydroperoxy Cyclophosphamide（4-羟基过氧化环磷酰胺），环磷酰胺的活性代谢产物，能够交联DNA并独立于caspase受体激活诱导T细胞凋亡，通过产生活性氧（ROS）激活线粒体死亡途径。

GC42197 2-Thiouridine

2-硫代尿苷

A modified nucleobase

GC42151 2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)

dGMP

A natural precursor of dGTP

GC42080 2'2'-cGAMP (sodium salt)

Adenosine-Guanosine 2’,2’-cyclic monophosphate, cGAMP(2’-5’), 2’,2’-Cyclic GMP-AMP

A synthetic dinucleotide

GC42061 2',3'-Dideoxyadenosine 5'-triphosphate

2',3'-Dideoxyadenosine 5'-triphosphate

2',3'-Dideoxyadenosine 5'-triphosphate (2',3'-Dideoxyadenosine 5'-triphosphate), an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase.

GC41859 1,5,7-Triazabicyclo[4.4.0]dec-5-ene

157-三叠氮双环(4.4.0)癸-5-烯

A bicyclic guanidine catalyst

GC41716 (R)-CR8

(2R)-2-[[9-异丙基-6-[[[4-(2-吡啶基)苯基]甲基]氨基]-9H-嘌呤-2-基]氨基]-1-丁醇,CR8, (R)-Isomer

An inhibitor of cyclin-dependent kinases

GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)

Tetrahydrofolate, THFA

A folic acid derivative

GC41643 9(Z),11(E),13(E)-Octadecatrienoic Acid

αEleostearic Acid, αESA, LAF 237

A polyunsaturated fatty acid

GC41633 (R)-Prunasin

野黑樱苷

A cyanogenic glucoside

GC41598 Tyrocidine Complex An antibiotic complex

GC41384 K-TMZ A DNA alkylating agent

GC41340 Illudin M

隐陡头菌素M

A DNA alkylating agent

GC41112 Dihydroxy Melphalan

二羟基美法兰

An inactive degradation product of melphalan

GC41088 (6S)-Tetrahydrofolic Acid

An active diastereomer

GC41085 HDAC6 Inhibitor

Histone Deacetylase 6

An inhibitor of HDAC6

GC40859 Steffimycin B

司替霉素B

An anthracycline bacterial metabolite

GC40683 N-(2-hydroxyethyl)-Naphthalimide

N-(2-hydroxyethyl)-1,8-Naphthalimide, NSC 11547

A fluorescent probe

GC40641 5'-Ethynyl-2'-deoxycytidine

5-乙炔基-2'-脱氧胞苷

A nucleoside analog

GC40618 3',4',7-Trihydroxyisoflavone

3',4',7-三羟基异黄酮

A natural isoflavone

GC40477 4-Thiouracil

4-硫尿嘧啶

A photoreactive nucleobase analog

GC40468 1,5-Isoquinolinediol

1,5-二羟基异喹啉,NSC 65585

An inhibitor of poly(ADP-ribose) polymerases

GC40301 Tamoxifen N-oxide

他莫昔芬N-氧化物

A metabolite of tamoxifen

GC40298 N-acetyl-5-Aminosalicylic Acid

5-乙酰氨基水杨酸

A metabolite of 5-ASA and sulfasalazine

GC19542 GeA-69 GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂，靶向大结构域 2 (MD2)，Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。

GC10456 Fucosterol

岩皂甾醇,24-ethylidene Cholesterol

A natural phytosterol with diverse biological activities

GC34749 Rac-Nedisertib Rac-Nedisertib(Rac-M3814)是Nedisertib的外消旋体，为有效的DNA-PK抑制剂，IC50值小于3nM。

GC34692 NU6140 A Cdk2 inhibitor

GC34670 MF-094 MF-094, a potent and selective USP30 inhibitor (IC50=0.12 μM), accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.

GC34650 Longdaysin

Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.

GC34629 J22352 J22352是一种具有类似靶向嵌合体蛋白水解(PROTAC)特性、高度选择性HDAC6抑制剂，其IC50值为4.7nM，J22352通过抑制胶质母细胞瘤自噬、诱发抗肿瘤免疫反应来促进HDAC6降解和诱导抗癌效果，并通过降低PD-L1的免疫抑制活性，使宿主抗肿瘤活性恢复。

GC34536 CK1-IN-1 CK1-IN-1 (PUN51207, Compound 1C) is an inhibitor of casein kinase 1 (CK1) with IC50 of 15 nM, 16 nM and 73 nM for CK1δ, CK1ε and p38α MAPK, respectively.