DNA Damage/DNA Repair(DNA损伤/DNA修复)

Cat.No. 产品名称 Information

GC34356 Casein Kinase II Inhibitor IV Hydrochloride CaseinKinaseIIInhibitorIVHydrochloride是表皮角质形成细胞分化的小分子诱导剂。

GC34355 SEL120-34A monohydrochloride A dual inhibitor of Cdk8 and Cdk19

GC34354 GSK2643943A GSK2643943A is an inhibitor of deubiquitylating enzyme (DUB) with IC50 of 160 nM for USP20/Ub-Rho.

GC34309 Cycloguanil D6 (Chlorguanide triazine D6) CycloguanilD6是Cycloguanil的氘代化合物标准品。

GC34305 Bendamustine D4 (SDX-105 D4) BendamustineD4是Bendamustine的氘代化合物标准品。Bendamustine是一种DNA交联剂(DNAcrosslinker)，能够导致DNA断裂，具有烷基化和抗代谢物的作用。

GC34205 GSK2850163 hydrochloride GSK2850163hydrochloride是一个新型的肌醇需要酶-1α(IRE1α)抑制剂，它可抑制IRE1α的激酶活性和RNA酶活性，其IC50值分别为20和200nM。

GC34204 JSH-150 JSH-150 is a highly selective and potent inhibitor of CDK9 with IC50 of 1 nM.

GC34195 K-756 K-756是一种直接的选择性tankyrase(TNKS)抑制剂，抑制TNKS1和TNKS2的ADP-核糖基化活性，IC50分别为31和36nM。

GC34169 Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride)

AQ4N-d12 dihydrochloride

Banoxantrone-d12 (AQ4N-d12) dihydrochloride 是氘标记的 Banoxantrone dihydrochloride。 Banoxantrone 是一种新型生物还原剂，可以还原为稳定的 DNA 亲和化合物 AQ4，它是一种有效的拓扑异构酶 II 抑制剂。

GC34165 Corin Corin是组氨酸赖氨酸特异性去甲基化酶(LSD1)和组氨酸脱乙酰化酶(HDAC)的双重抑制剂，其对LSD1的Ki(inact)值为110nM，对HDAC1的IC50值为147nM。

GC34163 Lerociclib (G1T38)

G1T38

G1T38 (Lerociclib) is a novel, potent, selective, and orally bioavailable CDK4/6 inhibitor with IC50 values of 0.001 μM, 0.002 μM and 0.028 μM for CDK4, CDK6 and CDK9 respectively.

GC34156 Namitecan (ST-1968)

ST-1968

Namitecan (ST-1968) 是一种有效的拓扑异构酶 I 抑制剂，具有抗肿瘤特性。

GC34144 Karenitecin (Cositecan)

(4S)-4-乙基-4-羟基-11-(2-三甲基硅基)乙基)-1H-吡喃并[3',4':6,7]氮茚并[1,2-B]喹啉-3,14(4H,12H)-二酮,Cositecan; BNP 1350

Karenitecin (Cositecan) (Cositecan) 是一种拓扑异构酶 I 抑制剂，具有有效的抗癌活性。

GC34127 GDC-0575 dihydrochloride (ARRY-575 dihydrochloride)

ARRY-575 dihydrochloride; RG7741 dihydrochloride

A Chk1 inhibitor

GC34124 (rel)-MC180295

(rel)-MC180295

MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs.

GC34123 Deoxycytidine triphosphate (dCTP)

脱氧胞苷三磷酸; dCTP; 2′-Deoxycytidine-5′-triphosphate

脱氧胞苷三磷酸 (dCTP) (dCTP) 是一种核苷三磷酸，可用于 DNA 合成。

GC34121 CC-115 hydrochloride A dual inhibitor of mTOR and DNA-PK

GC34120 Niraparib R-enantiomer (MK 4827 (R-enantiomer))

MK 4827 (R-enantiomer)

Niraparib R-enantiomer (MK-4827 R-enantiomer) 是一种出色的 PARP1 抑制剂，IC50 为 2.4 nM。

GC34118 Trilaciclib (G1T28)

曲拉西利,G1T28

Trilaciclib (G1T28, G1T28-1) is a highly potent, selective and reversible cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. Trilaciclib inhibits CDK4/cyclin D1 and CDK6/cyclin D3 with IC50 of 1 nM and 4 nM, respectively.

GC34112 Ethynylcytidine (ECyD)

ECyD; TAS-106; 3'-C-Ethynylcytidine

A nucleoside analog with anticancer activity

GC34111 NSC95682 (6-Bromo-2-hydroxy-3-methoxybenzaldehyde)

6-溴-2-羟基于-甲氧基苯甲醛,NSC95682

6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine. 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is an IRE-1α inhibitor with an IC50 of 0.08 μM.

GC34100 Lerociclib dihydrochloride (G1T38 dihydrochloride)

G1T38 dihydrochloride

Lerociclib dihydrochloride (G1T38 dihydrochloride) (G1T38 dihydrochloride) 是一种有效的选择性 CDK4/CDK6 抑制剂，对 CDK4/CyclinD1 和 CDK6/CyclinD3 的 IC50 分别为 1 nM 和 2 nM。

GC34090 Acelarin (NUC-1031)

N-(2'-脱氧-2',2'-二氟-P-苯基-5'-胞苷酰)-L-丙氨酸苄酯,NUC-1031

A prodrug form of gemcitabine

GC34087 Trilaciclib hydrochloride (G1T28 hydrochloride)

曲拉西利双盐酸盐,G1T28 hydrochloride

Trilaciclib hydrochloride (G1T28 hydrochloride) (G1T28 hydrochloride) 是一种 CDK4/6 抑制剂，对 CDK4 和 CDK6 的 IC50 分别为 1 nM 和 4 nM。

GC34086 SJG-136 (NSC-694501)

NSC-694501

SJG-136 (NSC-694501) 是一种 DNA 交联剂，对于 pBR322 DNA 的 XL50 为 45 nM。 SJG-136 (NSC-694501) 具有有效的抗肿瘤活性。

GC34085 Banoxantrone dihydrochloride (AQ4N dihydrochloride)

AQ4N dihydrochloride

Banoxantrone dihydrochloride (AQ4N dihydrochloride) 是一种缺氧活化拓扑异构酶 II 抑制剂，AQ4N 以非共价方式与 DNA 结合，促进缺氧和缺氧肿瘤细胞的抗肿瘤活性。

GC34083 EOAI3402143 EOAI3402143 is a dose-dependent inhibitor of Usp9x, Usp24 and Usp5 that increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice.

GC34071 Pamiparib (BGB-290)

帕米帕利,BGB-290

A PARP1 and PARP2 inhibitor

GC34059 Atuveciclib Racemate (BAY-1143572 Racemate)

BAY-1143572 Racemate

Atuveciclib (BAY-1143572) is potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.