DNA Damage/DNA Repair(DNA损伤/DNA修复)

Cat.No. 产品名称 Information

GC33353 ON-013100 ON-013100，一种抗肿瘤药物，作为有丝分裂的抑制剂，能够抑制细胞周期蛋白D1(CyclinD1)的表达。

GC33331 BRD 4354 BRD4354是HDAC5和HDAC9适度抑制剂，其IC50值分别为0.85，1.88μM。

GC33327 CMPD 7 CMPD 7 是一种有效的选择性 CDK12 抑制剂，在酶促试验中的 IC50 为 491 nM。

GC33325 VX-984 (M9831)

M9831

VX-984 (M9831) (M9831) 是一种具有口服活性、强效、选择性和 BBB 穿透的 DNA-PK 抑制剂。 VX-984 (M9831) 有效抑制 NHEJ（非同源末端连接）并增加 DSB（DNA 双链断裂）。 VX-984 (M9831) 可用于胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSCLC) 研究。

GC33322 LY 254155 LY254155是一种抗叶酸剂。LY254155抑制hGARFT及与mFBP结合，Kis分别为2.1±0.2和1.7±0.1nM。

GC33320 CM-579 CM-579是一线的、可逆的，G9a和DNA甲基转移酶(DNMT)的双抑制剂，其IC50值分别为16nM和32nM。在多种癌细胞中发挥有效活性作用。

GC33317 HDAC6-IN-1 SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.

GC33290 Remetinostat (SHP-141)

SHP-141

Remetinostat (SHP-141) (SHP-141) 是一种基于异羟肟酸的组蛋白脱乙酰酶 (HDAC) 抑制剂，正在开发用于治疗皮肤 T 细胞淋巴瘤。

GC33289 CHK1-IN-2 CHK1-IN-2是细胞周期检测点激酶(CHK1)的抑制剂，其IC50为6nM。

GC33240 Banoxantrone D12 (AQ4N D12)

AQ4N D12

Banoxantrone D12 (AQ4N D12) 是氘标记的banoxantrone。 Banoxantrone 是一种新型生物还原剂，可以还原为稳定的 DNA 亲和化合物 AQ4，它是一种有效的拓扑异构酶 II 抑制剂。

GC33223 BRCA1-IN-1 BRCA1-IN-1是一种新型的小分子BRCA1抑制剂，IC50和Ki分别为0.53μM和0.71μM。

GC33205 Indotecan (LMP-400)

LMP-400; NSC-724998

Indotecan (LMP-400) (LMP-400) 是一种有效的拓扑异构酶 1(Top1) 抑制剂，对 P388、HCT116、MCF-7 细胞系的 IC50 值分别为 300、1200、560 nM。

GC33202 LMP744 hydrochloride (MJ-III65 hydrochloride)

MJ-III65 hydrochloride; NSC706744 hydrochloride

LMP744 hydrochloride (MJ-III65 hydrochloride) (MJ-III65 hydrochloride) 是一种 DNA 嵌入剂和拓扑异构酶 I (Top1) 抑制剂，具有抗肿瘤活性。

GC33180 CDK8-IN-1 CDK8-IN-1是一个有效的、CDK8的选择性抑制剂，其IC50值为3nM。

GC33177 CNDAC

4-氨基-1-(2-氰基-2-脱氧-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮

CNDAC是sapacitabine的有效代谢物，为一种核苷类似物。

GC33165 Intoplicine

茚托利辛; RP 60475

Intoplicine是DNA拓扑异构酶I和II抑制剂。

GC33159 Givinostat hydrochloride (ITF-2357 hydrochloride)

ITF-2357 hydrochloride

HDAC inhibitor with anti-inflammatory and antineoplastic activities

GC33148 DC-05 A non-nucleoside DNMT1 inhibitor

GC33143 Podocarpusflavone A

竹柏双黄酮 A；罗汉松双黄酮A

A biflavone with diverse biological activities

GC33137 SEL120-34A A dual inhibitor of Cdk8 and Cdk19

GC33128 Edotecarin (J 107088)

J 107088; PF 804950

Edotecarin (J 107088) 是一种有效的拓扑异构酶 I 抑制剂，可诱导单链 DNA 切割，IC50 为 50 nM。

GC33127 TAS-103 (BMS-247615)

BMS-247615

TAS-103 (BMS-247615) 是 DNA 拓扑异构酶 I/II 的双重抑制剂，用于癌症研究。

GC33124 Datelliptium chloride Datelliptiumchloride是一种源于ellipticine的DNA嵌合剂，具有抗肿瘤活性。

GC33115 Pomiferin (NSC 5113)

橙桑黄酮; NSC 5113

Pomiferin (NSC 5113) (NSC 5113) 作为 HDAC 的潜在抑制剂，其 IC50 为 1.05 μM，并且还有效抑制 mTOR (IC50, 6.2 μM)。

GC33108 Exatecan (DX-8951)

依喜替康; DX-8951

Exatecan (DX-8951) is a nonprodrug camptothecin (CPT) derivative, exhibits significant topoisomerase I inhibition.

GC33107 (±)-BAY-1251152

(±)-BAY-1251152; (±)-VIP152

A racemic mixture of (+)-BAY-1251152 and (–)-BAY-1251152

GC33094 GC7 Sulfate

DHPS抑制剂

A deoxyhypusine synthase inhibitor

GC33066 Belotecan hydrochloride (CKD-602)

CKD-602盐酸盐,CKD-602

A DNA topoisomerase I inhibitor

GC33050 Givinostat (ITF-2357)

[4-[(羟基氨基)羰基]苯基]氨基甲酸[6-[(二乙基氨基)甲基]-2-萘基]甲酯,ITF-2357

HDAC inhibitor with anti-inflammatory and antineoplastic activities

GC33049 FN-1501 FN-1501 is a potent inhibitor of Fms-like receptor tyrosine kinase 3 (FLT3) and cyclin-dependent kinase (CDK), with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively.

GC33029 Forodesine (BCX-1777 freebase)

呋咯地辛; BCX-1777; Immucillin-H

A nucleoside analog and PNP inhibitor

GC32975 6-Mercaptopurine hydrate

6-巯基嘌呤一水合物; Mercaptopurine hydrate; 6-MP hydrate

An inhibitor of purine synthesis and interconversion

GC32970 MBQ-167

MBQ-167是Ras相关的C3型肉毒素底物(Rac)和细胞分裂周期蛋白(Cdc42)的双抑制剂，其对Rac1/2/3的IC50值为103nM，对Cdc42的IC50值为78nM。

GC32964 NKL 22

Histone Deacetylase Inhibitor IV

A selective HDAC1/3 inhibitor

GC32946 PK11007 PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.

GC32930 Simurosertib (TAK-931)

TAK-931

An inhibitor of Cdc7 kinase

GC32926 Dxd (Exatecan derivative)

DX-8951衍生物,Exatecan derivative for ADC

DXd 是 Exatecan (DX-8951) 的衍生物。

GC32918 Treosulfan (NSC 39069)

曲奥舒凡,NSC 39069; Treosulphan

Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.

GC32917 FT827 FT827是选择性和共价的泛素特异性蛋白酶7(USP7)抑制剂，IC50值为52nM。

GC32910 MKC9989

MKC9989是一种HAA抑制剂，且能抑制IRE1α其IC50值在0.23μM至44μM的范围之间。

GC32898 SEL120-34A HCl A dual inhibitor of Cdk8 and Cdk19

GC32889 MKC8866 (IRE-1α inhibitor 1)

Orin1001

MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29?μM for human IRE1α in vitro.

GC32886 Miriplatin (SM-11355)

米铂,SM-11355

Miriplatin (SM-11355) is a derivative of cisplatin containing myristates as a carrier ligand. It is a novel lipophilic platinum complex developed to treat hepatocellular carcinoma.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.