DNA Damage/DNA Repair(DNA损伤/DNA修复)

Cat.No. 产品名称 Information

GC32829 NU6300 NU6300是一种共价的ATP竞争性CDK2抑制剂。

GC32822 TAS-103 dihydrochloride (BMS-247615 dihydrochloride)

6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐,BMS-247615 dihydrochloride

A DNA topoisomerase I and II inhibitor

GC32793 Rucaparib Camsylate

瑞卡帕布樟脑磺酸盐,AG014699 camsylate; PF-01367338 camsylate

A PARP1 inhibitor

GC32786 FT671 FT671是有效，选择性的USP7抑制剂，IC50值为52nM，与USP7催化域结合的Kd值为65nM。

GC32746 MSC2530818 A Cdk8 inhibitor

GC32741 CCT-251921 CCT-251921是有效，选择性，有口服活性的CDK8抑制剂；IC50值为2.3nM。

GC32739 GCN2iB GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM.

GC32735 Samuraciclib hydrochloride (ICEC0942 hydrochloride)

CT7001 hydrochloride; ICEC0942 hydrochloride

Samuraciclib hydrochloride (ICEC0942 hydrochloride, CT7001 hydrochloride) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. ICEC0942 (CT7001) promotes cell cycle arrest and apoptosis.

GC32727 GNE-6776 GNE-6776 is a potent, non-covalent, selective and orally bioavailable inhibitor of USP7 with IC50 of 1.34 μM and 0.61 μM for full length USP7 and USP7 catalytic domain, respectively.

GC32720 ML364 An inhibitor of USP2

GC32718 M3814 (nedisertib)

M3814

Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM.

GC32717 AZD4573 AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases.

GC32714 Mitoxantrone (mitozantrone)

米托蒽醌; Mitozantrone; NSC 301739

米托蒽醌Mitoxantrone是一种抗肿瘤的蒽醌衍生物。

GC32708 Forodesine hydrochloride (BCX-1777)

BCX-1777 hydrochloride; Immucillin-H hydrochloride

A nucleoside analog and PNP inhibitor

GC32702 Branaplam (LMI070)

LMI070; NVS-SM1

An SMN2 splice modulator

GC32700 CYC065

CYC065

An inhibitor of Cdk2 and Cdk9

GC32565 CRA-026440 CRA-026440 是一种有效的广谱 HDAC 抑制剂。

GC32429 (-)-BAY-1251152

(-)-BAY-1251152; (-)-VIP152

A racemic mixture of (+)-BAY-1251152 and (–)-BAY-1251152

GC32401 EC0489 EC0489是叶酸和去乙酰长春碱酰肼的偶联物，是叶酸受体(FR)的高亲和力配体。有望治疗难治性或转移性肿瘤。是一种小分子-药物偶联物(SMDC)。

GC32343 Diaveridine (EGIS-5645)

二氨藜芦啶; EGIS-5645

A DHFR inhibitor with antimicrobial activity

GC32333 Beaucage reagent

Beaucage试剂

Beaucagereagent有效应用于DNA切割。

GC32250 Chebulinic acid

诃子林鞣酸

An ellagitannin with diverse biological activities

GC32187 Duocarmycin TM

CBI-TMI

DuocarmycinTM是一种非常有效的有抗肿瘤活性的抗生素。

GC32186 Puromycin (CL13900)

嘌呤霉素二盐酸盐水合物

Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

GC32181 Cefradine (Cephradine)

头孢拉定; Cefradine; SQ-11436

A β-lactam cephalosporin antibiotic

GC32088 Gepotidacin (GSK2140944)

GSK2140944

Gepotidacin (GSK2140944) (GSK2140944) 是一种新型三氮杂苊细菌 II 型拓扑异构酶抑制剂。

GC31950 Halofuginone hydrobromide (RU-19110 (hydrobromide))

常山酮溴酸盐; RU-19110 hydrobromide

Halofuginone (RU-19110) hydrobromid 是一种Ferifugine 衍生物，是一种竞争性脯氨酰-tRNA 合成酶抑制剂，Ki 为 18.3 nM。

GC31879 Kira8

AMG-18

Kira8 (Ire-1 inhibitor, AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.

GC31868 Thiarabine (OSI-7836)

OSI-7836

Thiarabine (OSI-7836) (OSI-7836) 显示出有效的抗肿瘤活性和对 DNA 合成的抑制作用。

GC31684 Dithranol (Anthralin)

蒽林; Anthralin

An anthrone inhibitor of keratinocyte proliferation

GC31650 Halofuginone (RU-19110)

常山酮; RU-19110

Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.

GC31511 Sinapinic acid (Sinapic acid)

芥子酸; Sinapic acid

A phenylpropanoid hydroxycinnamic acid with diverse biological activities

GC31365 γ-Oryzanol

γ-谷维素

Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass. γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).

GC31187 5-Methoxyflavone

5-甲氧基黄酮

5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.

GC30977 Ca2+ channel agonist 1 Ca2+channelagonist1是一种N-型钙离子通道(N-typeCa2+channel)激动剂和Cdk2的抑制剂，EC50分别为14.23μM和3.34μM，对运动神经终端功能障碍有潜在疗效。

GC30845 Risdiplam (RG7916)

RG7916; RO7034067

Risdiplam (RG7916) 是一种小分子 SMN2 前体 mRNA 剪接修饰剂,可促进外显子 7 的包含和全长 SMN2 mRNA 的产生,从而补偿 SMN1 的损失。

GC30785 4E2RCat 4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5μM。

GC30782 ACY-775 An HDAC6 inhibitor

GC30763 Benzenebutyric acid (4-Phenylbutyric acid)

4-苯基丁酸; 4-PBA; Benzenebutyric acid

4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.

GC30695 Phen-DC3

Phen-DC3是一个G4特异性配体，可以抑制解旋酶FANCJ和DinG且IC50s值分别为65±6和50±10nM。

GC30554 Isocytosine

异胞嘧啶

Isocytosine (2-aminouracil) is an isomer of cytosine used in physical chemical studies involving metal complex binding, hydrogen-bonding, and tautomerism and proton transfer effects in nucleobases.