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Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair(DNA损伤/DNA修复)

  1. Cat.No. 产品名称 Information
  2. GC32727 GNE-6776 GNE-6776 is a potent, non-covalent, selective and orally bioavailable inhibitor of USP7 with IC50 of 1.34 μM and 0.61 μM for full length USP7 and USP7 catalytic domain, respectively.
  3. GC32720 ML364 An inhibitor of USP2
  4. GC32718 M3814 (nedisertib)

    M3814

     Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM.
  5. GC32717 AZD4573 AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases.
  6. GC32714 Mitoxantrone (mitozantrone)

    米托蒽醌; Mitozantrone; NSC 301739

     米托蒽醌Mitoxantrone是一种抗肿瘤的蒽醌衍生物。
  7. GC32708 Forodesine hydrochloride (BCX-1777)

    BCX-1777 hydrochloride; Immucillin-H hydrochloride

     A nucleoside analog and PNP inhibitor
  8. GC32702 Branaplam (LMI070)

    LMI070; NVS-SM1

     An SMN2 splice modulator
  9. GC32700 CYC065

    CYC065

     An inhibitor of Cdk2 and Cdk9
  10. GC32565 CRA-026440 CRA-026440 是一种有效的广谱 HDAC 抑制剂。
  11. GC32429 (-)-BAY-1251152

    (-)-BAY-1251152; (-)-VIP152

     A racemic mixture of (+)-BAY-1251152 and (–)-BAY-1251152
  12. GC32401 EC0489 EC0489是叶酸和去乙酰长春碱酰肼的偶联物，是叶酸受体(FR)的高亲和力配体。有望治疗难治性或转移性肿瘤。是一种小分子-药物偶联物(SMDC)。
  13. GC32343 Diaveridine (EGIS-5645)

    二氨藜芦啶; EGIS-5645

     A DHFR inhibitor with antimicrobial activity
  14. GC32333 Beaucage reagent

    Beaucage试剂

     Beaucagereagent有效应用于DNA切割。
  15. GC32250 Chebulinic acid

    诃子林鞣酸

     An ellagitannin with diverse biological activities
  16. GC32187 Duocarmycin TM

    CBI-TMI

     DuocarmycinTM是一种非常有效的有抗肿瘤活性的抗生素。
  17. GC32186 Puromycin (CL13900)

    嘌呤霉素二盐酸盐水合物

    Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.
  18. GC32181 Cefradine (Cephradine)

    头孢拉定; Cefradine; SQ-11436

     A β-lactam cephalosporin antibiotic
  19. GC32088 Gepotidacin (GSK2140944)

    GSK2140944

     Gepotidacin (GSK2140944) (GSK2140944) 是一种新型三氮杂苊细菌 II 型拓扑异构酶抑制剂。
  20. GC31950 Halofuginone hydrobromide (RU-19110 (hydrobromide))

    常山酮溴酸盐; RU-19110 hydrobromide

     Halofuginone (RU-19110) hydrobromid 是一种Ferifugine 衍生物，是一种竞争性脯氨酰-tRNA 合成酶抑制剂，Ki 为 18.3 nM。
  21. GC31879 Kira8

    AMG-18

    Kira8 (Ire-1 inhibitor, AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
  22. GC31868 Thiarabine (OSI-7836)

    OSI-7836

     Thiarabine (OSI-7836) (OSI-7836) 显示出有效的抗肿瘤活性和对 DNA 合成的抑制作用。
  23. GC31684 Dithranol (Anthralin)

    蒽林; Anthralin

     An anthrone inhibitor of keratinocyte proliferation
  24. GC31650 Halofuginone (RU-19110)

    常山酮; RU-19110

     Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.
  25. GC31511 Sinapinic acid (Sinapic acid)

    芥子酸; Sinapic acid

     A phenylpropanoid hydroxycinnamic acid with diverse biological activities
  26. GC31365 γ-Oryzanol

    γ-谷维素

     Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass. γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).
  27. GC31187 5-Methoxyflavone

    5-甲氧基黄酮

     5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
  28. GC30977 Ca2+ channel agonist 1 Ca2+channelagonist1是一种N-型钙离子通道(N-typeCa2+channel)激动剂和Cdk2的抑制剂，EC50分别为14.23μM和3.34μM，对运动神经终端功能障碍有潜在疗效。
  29. GC30845 Risdiplam (RG7916)

    RG7916; RO7034067

    Risdiplam (RG7916) 是一种小分子 SMN2 前体 mRNA 剪接修饰剂,可促进外显子 7 的包含和全长 SMN2 mRNA 的产生,从而补偿 SMN1 的损失 。
  30. GC30785 4E2RCat 4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5μM。
  31. GC30782 ACY-775 An HDAC6 inhibitor
  32. GC30763 Benzenebutyric acid (4-Phenylbutyric acid)

    4-苯基丁酸; 4-PBA; Benzenebutyric acid

    4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.
  33. GC30695 Phen-DC3

    Phen-DC3是一个G4特异性配体，可以抑制解旋酶FANCJ和DinG且IC50s值分别为65±6和50±10nM。
  34. GC30554 Isocytosine

    异胞嘧啶

    Isocytosine (2-aminouracil) is an isomer of cytosine used in physical chemical studies involving metal complex binding, hydrogen-bonding, and tautomerism and proton transfer effects in nucleobases.
  35. GC30548 6-Amino-5-nitropyridin-2-one

    6-氨基-5-硝基-2(1H)-吡啶酮

     6-Amino-5-nitropyridin-2-one是一种吡啶碱基，可用作hachimojiDNA的核酸碱基，并与5-aza-7-脱氮鸟嘌呤配对。
  36. GC30531 7-Methylguanosine

    7-甲基鸟苷

     A methylated form of guanosine
  37. GC30529 GNE-371 GNE-371是一种针对人类转录起始因子TFIID亚基1和类转录起始因子TFIID亚基1的第二溴端结构域的高效选择性化学探针，对TAF1(2)的IC50值为10nM。
  38. GC30526 ACY-957 ACY-957是一种选择性的HDAC1和HDAC2抑制剂，对HDAC1/2/3的IC50值分别为7nM，18nM和1300nM，对HDAC4/5/6/7/8/9无作用。
  39. GC30466 CDK8-IN-3 CDK8-IN-3是CDK8的抑制剂,来自专利WO2016041618A1，化合物实例1.7。
  40. GC30276 Casein Kinase II Inhibitor IV

    CaseinKinaseIIInhibitorIV是表皮角质形成细胞分化的小分子诱导剂。
  41. GC30245 CLK1-IN-1 CLK1-IN-1是一个有效的、Cdc2-like激酶(CLK1)的选择性抑制剂，其IC50值为2nM。
  42. GC30185 SMN-C3 SMN-C3是一种可口服的SMN2剪接调节剂，有治疗脊椎肌肉萎缩(SMA)的潜力。
  43. GC30106 CHK1 inhibitor

    GDC-0575 analog

     CHK1inhibitor是CHK1的抑制剂。
  44. GC19468 AZD1390 AZD1390 是一种强效、高选择性、口服生物可利用的脑渗透性 ATM 抑制剂，在细胞中的 IC50 为 0.78 nM。
  45. GC19451 SBI-0640756

    SBI-756

     SBI-0640756 (SBI-756) 是 eIF4G1 的抑制剂，可破坏 eIF4F 复合物。
  46. GC19406 TH34 TH34 是一种 HDAC6/8/10 抑制剂，IC50 分别为 4.6 μM、1.9 μM 和 7.7 μM，对 HDAC1/2/3 具有高选择性。
  47. GC19391 Zoliflodacin

    ETX0914; AZD0914

     A fluoroquinolone antibiotic
  48. GC19390 YU238259 An inhibitor of homology-dependent DNA repair
  49. GC19378 VLX1570 VLX1570 is an inhibitor of 19S proteasomal deubiquitinases
  50. GC19360 TMP195

    TMP195游离态

    TMP195 是一种有效的选择性 IIa 类 HDAC 抑制剂，对 HDAC4、HDAC5、HDAC7 和 HDAC9 的 IC50 分别为 59 nM、60 nM、26 nM 和 15 nM。
  51. GC19348 TAS-102

    TAS-102

     An orally bioavailable combination of a nucleoside analog and TPase inhibitor

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