DNA Damage/DNA Repair(DNA损伤/DNA修复)

Cat.No. 产品名称 Information

GC16455 Flumequine

氟甲喹; R-802

A fluoroquinolone antibiotic

GC15410 Bufexamac

丁苯羟酸; Bufexamic acid

An NSAID and a class IIb HDAC inhibitor

GC17683 Brefeldin A

布雷非德菌素 A; BFA; Cyanein; Decumbin

Brefeldin A（BFA）是一种真菌大环内酯，能够有效、可逆地抑制内质网和高尔基体之间的蛋白质运输和囊泡形成。

GC14987 GSK-3 Inhibitor IX (BIO)

(2'Z,3'E)-6-溴靛玉红-3'-肟,GSK-3 Inhibitor IX

A potent, selective, and reversible GSK3 inhibitor

GC11843 Azaguanine-8

8-氮鸟嘌呤

Azaguanine-8 是一种嘌呤类似物，具有抗肿瘤活性。 Azaguanine-8 起抗代谢物的作用，很容易与核糖核酸结合，干扰正常的生物合成途径，从而抑制细胞生长。

GC14493 4μ8C

4u8C

An IRE1α inhibitor

GC11528 Orotic acid

乳清酸; 6-Carboxyuracil; Vitamin B13

乳清酸 (6-Carboxyuracil) 是嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放出来，通过细胞质 UMP 合酶转化为 UMP。

GC10082 Vidarabine

阿糖腺苷; Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine

An antiviral nucleoside analog

GC15033 Azathioprine

硫唑嘌呤; BW 57-322

An immunosuppressive purine analog

GC14106 Adenosine

腺苷; Adenine riboside; D-Adenosine

A purine nucleoside

GC12423 Mycophenolate mofetil hydrochloride

RS 61443 hydrochloride; TM-MMF hydrochloride

A prodrug form of mycophenolic acid

GC13729 Cytidine

胞苷; Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside

A pyrimidine nucleoside

GC13432 Adenine

腺嘌呤; 6-Aminopurine; Vitamin B4

腺嘌呤（6-氨基嘌呤）是一种嘌呤，是DNA核酸中的四种核碱基之一。腺嘌呤是DNA和RNA的化学成分。腺嘌呤还在涉及细胞呼吸、ATP 和辅因子（NAD 和 FAD）的形式以及蛋白质合成的生物化学中发挥重要作用。

GC11099 Doxifluridine

去氧氟尿苷; Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR

An antitumor prodrug of 5-fluorouracil

GC13401 SJB3-019A SJB3-019A 是一种有效的新型 USP1 抑制剂，在促进 K562 细胞中 ID1 降解和细胞毒性方面的作用是 SJB2-043 的 5 倍，IC50 为 0.0781 μM。

GC15663 LY2606368

5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈,LY2606368

LY2606368 是一种 ATP 竞争性 CHK1 抑制剂，目前处于临床阶段，Ki 为 0.9 nM，IC50 <1 nM。

GC17635 ML-323 A selective USP1-UAF1 deubiquitinase complex inhibitor

GC17848 Penciclovir

喷昔洛韦; BRL 39123; VSA 671

An antiviral guanosine analog

GC10637 Zidovudine

叠氮胸苷; Azidothymidine; AZT; ZDV

A nucleoside reverse transcriptase inhibitor

GC13831 FT-207 (NSC 148958)

替加氟; FT 207; NSC 148958

A prodrug form of 5-fluorouracil

GC13667 Temozolomide

替莫唑胺; NSC 362856; CCRG 81045; TMZ

替莫唑胺是一种口服活性烷化剂，可诱导 DNA 中 O6-甲基鸟嘌呤的形成，其在随后的 DNA 复制周期中与胸腺嘧啶错配，从而激活细胞凋亡途径，替莫唑胺可穿过血脑屏障并适用于恶性神经胶质瘤和转移性黑色素瘤。

GC11048 Irinotecan HCl Trihydrate

盐酸伊立替康三水合物; (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate

A potent inhibitor of DNA topoisomerase I

GC15377 LEE011 succinate

瑞博西尼琥珀酸盐; LEE011 succinate

A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor

GC15922 LEE011 hydrochloride

瑞博西尼盐酸盐; LEE011 hydrochloride

A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor

GC17466 LH846 A selective inhibitor of CK1δ

GC13328 XL413 hydrochloride

BMS-863233 hydrochloride

A potent inhibitor of Cdc7

GC18117 XL413 A potent inhibitor of Cdc7

GC12350 T 705

法匹拉韦; T-705

An antiviral agent

GC11648 BML-277

Chk2 Inhibitor II

A selective DNA damage control kinase inhibitor

GC13359 Topotecan HCl

盐酸拓扑替康; SKF 104864A Hydrochloride; NSC 609669 Hydrochloride

A potent inhibitor of DNA topoisomerase I

GC17522 LY2334737

2'-脱氧-2',2'-二氟-N-(1-氧代-2-丙基戊基)胞苷

LY2334737 是一种核苷类似物，是吉西他滨的口服活性前药。

GC17865 Lomustine

洛莫司汀; CCNU; NSC 79037

A DNA alkylating agent

GC14961 Cytarabine hydrochloride

盐酸阿糖胞苷; Cytosine β-D-arabinofuranoside hydrochloride; Cytosine Arabinoside hydrochloride; Ara-C hydrochloride

A nucleoside analog and prodrug form of ara-CTP

GC11747 Amsacrine hydrochloride

盐酸胺苯吖啶,m-AMSA hydrochloride; acridinyl anisidide hydrochloride

A topoisomerase II poison

GC12326 Amsacrine

安吖啶; m-AMSA; acridinyl anisidide

A topoisomerase II poison

GC12828 Daunorubicin

柔红霉素; Daunomycin; RP 13057; Rubidomycin

Daunorubicin (Daunomycin) 是一种拓扑异构酶 II 抑制剂，具有有效的抗肿瘤活性。

GC10354 Daunorubicin HCl

盐酸柔红霉素; Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride

Antitumor antibiotic used in the treatment of acute myeloid leukemias

GC13858 Torin 2

9-(6-氨基-3-吡啶基)-1-[3-(三氟甲基)苯基]苯并[H]-1,6-萘啶-2(1H)-酮

Selective inhibitor of mTOR

GC11537 MK-4827 tosylate

尼拉帕尼对苯甲磺酸盐; MK-4827 tosylate

An orally bioavailable PARP1/2 inhibitor

GC12756 MK-4827 hydrochloride

MK-4827 hydrochloride

MK-4827 hydrochloride (MK-4827 hydrochloride) 是一种高效且具有口服生物利用度的 PARP1 和 PARP2 抑制剂，IC50 分别为 3.8 和 2.1 nM。 MK-4827 hydrochloride 抑制 DNA 损伤的修复，激活细胞凋亡并显示出抗肿瘤活性。