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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> PARP

PARP(多聚ADP核糖聚合酶)

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

Products for  PARP

  1. Cat.No. 产品名称 Information
  2. GC62121 Fluzoparib

    氟唑帕利; SHR3162; Fuzuloparib

     Fluzoparib (SHR3162, HS10160) is a potent Poly (ADP-ribose) polymerase (PARP) inhibitor that shows anti-tumor activity.
  3. GC62105 Senaparib

    IMP4297

     Senaparib (IMP4297) 是强效的、选择性的、口服有效的 PARP1/2 抑制剂。Senaparib (IMP4297) 在动物模型中表现强效的抗肿瘤活性。
  4. GC47693 m-Methoxybenzamide

    3-甲氧基苯甲酰胺,3-MBA

     A PARP inhibitor
  5. GC47056 CAY10753 A TNKS2 inhibitor
  6. GC47055 CAY10749 A dual inhibitor of PARP and PI3K
  7. GC46900 AZ9482 A PARP inhibitor
  8. GC50506 Fluorescein-NAD+

    荧光素-NAD+ 是放射性标记的 NAD 的替代品，也是 ADP 核糖基化的底物。
  9. GC39302 PARP14 inhibitor H10 PARP14 inhibitor H10 (化合物 H10) 是针对 PARP14 的选择性抑制剂 (IC50=490 nM)，是其他 PARP 的抑制剂 (约为 PARP1 的 24 倍)。PARP14 抑制剂 H10 诱导 caspase-3/7 介导的细胞凋亡 (apoptosis)。
  10. GC45808 OUL35

    NSC39047

     An inhibitor of PARP10
  11. GC45772 6(5H)-Phenanthridinone

    6(5H)-菲啶酮

     An inhibitor of PARP1 and 2
  12. GC37735 Tankyrase-IN-2 A TNKS1/2 inhibitor
  13. GC37728 Talazoparib tosylate

    BMN 673ts

     Talazoparib tosylate（BMN 673ts）是一种有效的具有口服活性的PARP1/2抑制剂，是Talazoparib的甲苯磺酸盐形式。Talazoparib抑制PARP1的IC50值为0.57nM。
  14. GC36855 Paris saponin VII

    重楼皂苷 VII; Chonglou Saponin VII

     Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
  15. GC36751 NMS-P515 NMS-P515 是有效的、口服有效的、立体定向的PARP-1 的抑制剂，Kd 值为16 nM，IC50 值为 27 nM (Hela 细胞中)。有抗肿瘤活性。
  16. GC35550 BRCA1-IN-2 BRCA1-IN-2 (compound 15) 是具有细胞渗透性的 BRCA1 蛋白-蛋白相互作用 (PPI) 的抑制剂，IC50 值 0.31 μM，Kd 值为 0.3 μM， BRCA1-IN-2 通过阻断 BRCA1 (BRCT)2/ 蛋白质相互作用而具有抗肿瘤活性。
  17. GC35547 BR102375 BR102375 是一种用于治疗 2 型糖尿病的 non-TZD (噻唑烷二酮类) PPAR γ 完全激动剂， 其 EC50 值和 Amax比率值分别为 0.28 μM 和 98%。
  18. GC35150 5,7,4'-Trimethoxyflavone

    5,7,4'-三甲氧基黄酮

     4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.
  19. GC40468 1,5-Isoquinolinediol

    1,5-二羟基异喹啉,NSC 65585

     An inhibitor of poly(ADP-ribose) polymerases
  20. GC19542 GeA-69 GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂，靶向大结构域 2 (MD2)，Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。
  21. GC10456 Fucosterol

    岩皂甾醇,24-ethylidene Cholesterol

     A natural phytosterol with diverse biological activities
  22. GC19505 RK-287107 A TNKS1/2 inhibitor
  23. GC34195 K-756 K-756是一种直接的选择性tankyrase(TNKS)抑制剂，抑制TNKS1和TNKS2的ADP-核糖基化活性，IC50分别为31和36nM。
  24. GC34120 Niraparib R-enantiomer (MK 4827 (R-enantiomer))

    MK 4827 (R-enantiomer)

     Niraparib R-enantiomer (MK-4827 R-enantiomer) 是一种出色的 PARP1 抑制剂，IC50 为 2.4 nM。
  25. GC34071 Pamiparib (BGB-290)

    帕米帕利,BGB-290

     A PARP1 and PARP2 inhibitor
  26. GC33358 WD2000-012547 WD2000-012547是一种选择性的PARP-1抑制剂，pKi为8.221。
  27. GC33223 BRCA1-IN-1 BRCA1-IN-1是一种新型的小分子BRCA1抑制剂，IC50和Ki分别为0.53μM和0.71μM。
  28. GC32793 Rucaparib Camsylate

    瑞卡帕布樟脑磺酸盐,AG014699 camsylate; PF-01367338 camsylate

     A PARP1 inhibitor
  29. GC19264 NMS-P118

    2-[1-(4,4-二氟环己基)-4-哌啶基]-6-氟-2,3-二氢-3-氧代-1H-异吲哚-4-甲酰胺

     A potent and selective PARP1 inhibitor
  30. GC18172 E7449

    E7449; 2X-121

     An inhibitor of PARP1, PARP2, and TNKS1/2
  31. GC11761 4-amino-1,8-Naphthalimide

    4-氨基-1,8-萘二胺,4-Aminonaphthalimide,4-ANI

     A PARP inhibitor
  32. GC16725 AZ6102

    REL-2-[4-[6-[(3R,5S)-3,5-二甲基-1-哌嗪基]-4-甲基-3-吡啶基]苯基]-3,7-二氢-7-甲基-4H-吡咯并[2,3-D]嘧啶-4-酮

     A TNKS1/2 inhibitor
  33. GC12844 Benzamide

    苯甲酰胺; Benzenecarboxamide; Phenylamide

     Benzamide (Benzenecarboxamide) 是一种有效的聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂。
  34. GC14251 Picolinamide

    2-吡啶甲酰胺,2-Picolinamide

     poly (ADP-ribose) synthetase inhibitor
  35. GC14380 BGP-15

    (Z)-N-(2-羟基-3-(哌啶-1-基)丙氧基)烟酰胺双盐酸盐

     A PARP inhibitor and insulin sensitizer
  36. GC17555 NVP-TNKS656

    TNKS656

     A TNKS2 inhibitor
  37. GC16914 MN 64 A TNKS inhibitor
  38. GC13541 G007-LK

    Tankyrase 1/2 Inhibitor VI

     A TNKS1/2 inhibitor
  39. GC13249 Rucaparib (free base)

    瑞卡帕布; AG014699; PF-01367338

     A PARP1 inhibitor
  40. GC11537 MK-4827 tosylate

    尼拉帕尼对苯甲磺酸盐; MK-4827 tosylate

     An orally bioavailable PARP1/2 inhibitor
  41. GC12756 MK-4827 hydrochloride

    MK-4827 hydrochloride

     MK-4827 hydrochloride (MK-4827 hydrochloride) 是一种高效且具有口服生物利用度的 PARP1 和 PARP2 抑制剂，IC50 分别为 3.8 和 2.1 nM。 MK-4827 hydrochloride 抑制 DNA 损伤的修复，激活细胞凋亡并显示出抗肿瘤活性。
  42. GC13419 ME0328 A selective PARP3 inhibitor
  43. GC11548 Tankyrase Inhibitors (TNKS) 49

    TNKS 49;TNKS49;TNKS-49

     Tankyrase inhibitor
  44. GC15041 Tankyrase Inhibitors (TNKS) 22

    TNKS 22;TNKS22;TNKS-22

     Tankyrase inhibitor
  45. GC12781 XAV-939

    3,5,7,8-四氢-2-[4-(三氟甲基)苯基]-4H-噻喃并[4,3-D]嘧啶-4-酮

     XAV-939 选择性抑制 β-连环蛋白介导的转录。
  46. GC11674 WIKI4

    Tankyrase 1/2 Inhibitor V

     A potent TNKS1/2 inhibitor
  47. GC17775 NU 1025

    NSC 696807

     An inhibitor of PARP
  48. GC12869 JW 55

    Tankyrase 1/2 Inhibitor IV

     A TNKS1/2 inhibitor
  49. GC12991 EB 47 A PARP1 and TNKS2 inhibitor
  50. GC12680 DR 2313

    3,5,7,8-四氢-2-甲基-4H-硫代吡喃并[4,3-D]嘧啶-4-酮

     A PARP inhibitor
  51. GC14434 BYK 49187 Potent PARP-1/PARP-2 inhibitor

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