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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> Nucleoside Antimetabolite/Analogue

Nucleoside Antimetabolite/Analogue(核苷抗代谢物/类似物)

Nucleoside analouges belong to the fmalily of antimetablits that resemble the neleosieds for uptake and metaolism that inibitr dna sytnse and couase cain termination. It is a durg target for cacner and viral infcations.

Products for  Nucleoside Antimetabolite/Analogue

  1. Cat.No. 产品名称 Information
  2. GC36071 Fosteabine

    阿糖胞苷烷磷酯; Cytarabine ocfosfate; YNK 01

     Fosteabine 是一种口服的、阿糖胞苷的前体药物类似物，具有抗脱氧胞苷脱氢酶的活性。
  3. GC35693 CI 972 (anhydrous) CI 972 anhydrous 是一会有效的，具有口服活性的，竞争性的嘌呤核苷磷酸化酶 (PNP) (Ki=0.83 μM)，正在开发作为T细胞选择性免疫抑制剂。
  4. GC35171 6-Thioinosine

    6-疏基嘌呤核苷,6TI; 6-Mercaptopurine riboside

     6-?Thioinosine (6TI) 是一种嘌呤抗代谢物，为抗脂肪形成剂，能够降低 PPAR γ 和 C/EBPα 及其目标基因 LPL，CD36，aP2 和 LXRα 的 mRNA 水平。
  5. GC35105 3'-Azido-3'-deoxy-beta-L-uridine 3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) 是一种核苷衍生物。
  6. GC35072 2'-O,4'-C-Methyleneuridine

    1-(2'-O,4-C-甲桥-BETA-D-呋喃核糖基)尿嘧啶核苷

     2’-O,4’-C-Methyleneuridine (Compound 15a) 是一种双环核苷。
  7. GC42474 4-Thiouridine

    4-硫代尿苷

    4-Thiouridine 4-硫脲(4sU)是核糖核苷类似物，可用于RNA分析和(m)RNA标记。
  8. GC34123 Deoxycytidine triphosphate (dCTP)

    脱氧胞苷三磷酸; dCTP; 2′-Deoxycytidine-5′-triphosphate

     脱氧胞苷三磷酸 (dCTP) (dCTP) 是一种核苷三磷酸，可用于 DNA 合成。
  9. GC34112 Ethynylcytidine (ECyD)

    ECyD; TAS-106; 3'-C-Ethynylcytidine

     A nucleoside analog with anticancer activity
  10. GC33959 Nucleoside-Analog-2 Nucleoside-Analog-2是针对丙型肝炎病毒（HCV）复制的4'-叠氮胞苷类似物。
  11. GC33956 Nucleoside-Analog-1 Nucleoside-Analog-1是抗病毒核苷R1479的类似物，用于HCV看病毒核苷类似物的合成。
  12. GC33944 Pseudothymidine (5-Methyl-2'-Deoxypseudouridin)

    5-(2-脱氧-BETA-D-赤式-呋喃戊糖基)-1-甲基-2,4(1H,3H)-嘧啶二酮,5-Methyl-2'-Deoxypseudouridin

     Pseudothymidine (5-Methyl-2'-Deoxypseudouridin) 是胸苷的 C-核苷类似物。
  13. GC33662 Isoguanine

    异鸟嘌呤

     An isomer of guanine
  14. GC33494 Deoxypseudouridine

    脱氧假尿苷

     Deoxypseudouridine是一种核苷酸类似物。
  15. GC33430 2'-Deoxypseudoisocytidine 2'-Deoxypseudoisocytidine是一个核苷类似物。
  16. GC33177 CNDAC

    4-氨基-1-(2-氰基-2-脱氧-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮

     CNDAC是sapacitabine的有效代谢物，为一种核苷类似物。
  17. GC33029 Forodesine (BCX-1777 freebase)

    呋咯地辛; BCX-1777; Immucillin-H

     A nucleoside analog and PNP inhibitor
  18. GC32975 6-Mercaptopurine hydrate

    6-巯基嘌呤 一水合物; Mercaptopurine hydrate; 6-MP hydrate

     An inhibitor of purine synthesis and interconversion
  19. GC32708 Forodesine hydrochloride (BCX-1777)

    BCX-1777 hydrochloride; Immucillin-H hydrochloride

     A nucleoside analog and PNP inhibitor
  20. GC30554 Isocytosine

    异胞嘧啶

    Isocytosine (2-aminouracil) is an isomer of cytosine used in physical chemical studies involving metal complex binding, hydrogen-bonding, and tautomerism and proton transfer effects in nucleobases.
  21. GC30548 6-Amino-5-nitropyridin-2-one

    6-氨基-5-硝基-2(1H)-吡啶酮

     6-Amino-5-nitropyridin-2-one是一种吡啶碱基，可用作hachimojiDNA的核酸碱基，并与5-aza-7-脱氮鸟嘌呤配对。
  22. GC30531 7-Methylguanosine

    7-甲基鸟苷

     A methylated form of guanosine
  23. GC19348 TAS-102

    TAS-102

     An orally bioavailable combination of a nucleoside analog and TPase inhibitor
  24. GC19319 Sapacitabine

    N-[1-[(2R,3S,4S,5R)-3-氰基-4-羟基-5-(羟甲基)氧杂环戊-2-基]-2-氧代嘧啶-4-基]十六酰胺,CS682; CYC682

     Sapacitabine 是一种可口服的核苷类似物前药，在结构上与阿糖胞苷相关。
  25. GC11222 Methylthioadenosine

    5-脱氧-5-甲硫腺苷,5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine

     Methylthioadenosine是多胺生物合成过程中由 S-腺苷甲硫氨酸(SAMe)产生的含硫腺嘌呤核苷。Methylthioadenosine常用于结肠炎、肝病和各种癌症疾病的研究。
  26. GC11654 Enocitabine

    依诺他滨

     A prodrug form of cytarabine
  27. GC16514 Penciclovir Sodium

    VSA 671 sodium; BRL 39123A; BRL 39123D

     An antiviral guanosine analog
  28. GC11940 5-BrdU

    5-溴脱氧尿嘧啶核苷; BrdU; 5-Bromo-2'-deoxyuridine; BUdR

     5-溴-2’-脱氧尿苷（5-BrdU，5-bromo-2-deoxundine5-BrdU）是一种合成的胸苷溴化类似物，通常用于测定DNA合成和标记分裂细胞。
  29. GC17750 Raltitrexed

    雷替曲塞; ZD1694; D1694; ICI-D1694

     An inhibitor of thymidylate synthase
  30. GC11843 Azaguanine-8

    8-氮鸟嘌呤; 8-AG

     Azaguanine-8 是一种嘌呤类似物，具有抗肿瘤活性。 Azaguanine-8 起抗代谢物的作用，很容易与核糖核酸结合，干扰正常的生物合成途径，从而抑制细胞生长。
  31. GC11528 Orotic acid

    乳清酸; 6-Carboxyuracil; Vitamin B13

     乳清酸 (6-Carboxyuracil) 是嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放出来，通过细胞质 UMP 合酶转化为 UMP。
  32. GC10082 Vidarabine

    阿糖腺苷; Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine

     An antiviral nucleoside analog
  33. GC14106 Adenosine

    腺苷; Adenine riboside; D-Adenosine

     A purine nucleoside
  34. GC13729 Cytidine

    胞苷; Cytosine β-D-riboside; Cytosine-1-β-D-ribofuranoside

     A pyrimidine nucleoside
  35. GC13432 Adenine

    腺嘌呤; 6-Aminopurine; Vitamin B4

     腺嘌呤（6-氨基嘌呤）是一种嘌呤，是DNA核酸中的四种核碱基之一。腺嘌呤是DNA和RNA的化学成分。腺嘌呤还在涉及细胞呼吸、ATP 和辅因子（NAD 和 FAD）的形式以及蛋白质合成的生物化学中发挥重要作用。
  36. GC11099 Doxifluridine

    去氧氟尿苷; Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR

     An antitumor prodrug of 5-fluorouracil
  37. GC17848 Penciclovir

    喷昔洛韦; BRL 39123; VSA 671

     An antiviral guanosine analog
  38. GC10637 Zidovudine

    叠氮胸苷; Azidothymidine; AZT; ZDV

     A nucleoside reverse transcriptase inhibitor
  39. GC13831 FT-207 (NSC 148958)

    替加氟; FT 207; NSC 148958

     A prodrug form of 5-fluorouracil
  40. GC17522 LY2334737

    2'-脱氧-2',2'-二氟-N-(1-氧代-2-丙基戊基)胞苷

     LY2334737 是一种核苷类似物，是吉西他滨的口服活性前药。
  41. GC14961 Cytarabine hydrochloride

    盐酸阿糖胞苷; Cytosine β-D-arabinofuranoside hydrochloride; Cytosine Arabinoside hydrochloride; Ara-C hydrochloride

     A nucleoside analog and prodrug form of ara-CTP
  42. GC15866 Capecitabine

    卡培他滨

     A prodrug of 5-fluorouracil
  43. GC13070 Cytarabine

    阿糖胞苷; Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C

     Cytarabine（Ara-C）是一种胞嘧啶类似物，主要抑制DNA聚合酶的功能来阻断DNA合成。
  44. GC13803 Triflurdine (Viroptic)

    曲氟尿苷; Trifluorothymidine; 5-Trifluorothymidine; TFT

     A thymidine analog that inhibits DNA synthesis
  45. GC16805 Gemcitabine

    吉西他滨; LY 188011

    An anticancer nucleoside analog
  46. GC15134 Fludarabine Phosphate (Fludara)

    磷酸氟达拉滨; NSC 118218 phosphate

     A prodrug form of fludarabine and 2-fluoro-ara-ATP
  47. GC14144 Fludarabine

    氟达拉滨; F-ara-A; NSC 118218

     Fludarabine是一种抑制DNA合成的嘌呤类似物。
  48. GC10591 Nelarabine

    奈拉滨; 506U78; GW 506U78; Nelzarabine

     A nucleoside analog used in the treatment of leukemia
  49. GC14485 Dacarbazine

    达卡巴嗪; Imidazole Carboxamide

     A DNA alkylating prodrug
  50. GC12748 Carmofur

    卡莫氟; HCFU

     An acid ceramidase inhibitor with anti-neoplastic activity
  51. GC13704 Mercaptopurine (6-MP)

    6-巯基嘌呤; Mercaptopurine; 6-MP

     巯基嘌呤（6-MP）是一种嘌呤类似物，可作为内源性嘌呤的拮抗剂，被广泛用作抗白血病药和免疫抑制剂。

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