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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> Topoisomerase

Topoisomerase(拓扑异构酶)

Topoisomerase are enzymes that regulate the overwinding or underwinding of DNA.

Products for  Topoisomerase

  1. Cat.No. 产品名称 Information
  2. GC36928 Pirarubicin Hydrochloride

    盐酸吡柔比星; THP Hydrochloride

     An anthracycline antitumor antibiotic
  3. GC36895 Phenoxodiol

    脱氢雌马酚,Idronoxil; Dehydroequol; Haginin E

     A phenol with anticancer activity
  4. GC36549 Mauritianin

    毛里求斯排草素

     A flavonoid glycoside and DNA topoisomerase I inhibitor
  5. GC36329 Irinotecan hydrochloride

    伊立替康盐酸盐; (+)-Irinotecan hydrochloride; CPT-11 hydrochloride

     A potent inhibitor of DNA topoisomerase I
  6. GC35997 Epirubicin

    表柔比星; 4'-Epidoxorubicin

     An anthracycline antitumor antibiotic
  7. GC35973 Ellipticine hydrochloride

    玫瑰树碱盐酸盐; NSC 71795 hydrochloride

     A DNA-intercalating antitumor agent
  8. GC35497 Berberine chloride hydrate

    盐酸黄连素水合物; Natural Yellow 18 chloride hydrate

     As isoquinoline alkaloid with diverse biological activities
  9. GC35238 Aclacinomycin A hydrochloride

    盐酸阿柔比星; Aclarubicin hydrochloride

     Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子，是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效治疗血癌和实体肿瘤的蒽环类化疗药物。
  10. GC35190 7-Ethylcamptothecin

    7-乙基喜树碱

     An anticancer agent
  11. GC14858 Aldoxorubicin

    INNO-206;Doxorubicin-EMCH;INNO 206

     A prodrug form of doxorubicin
  12. GC45009 Temafloxacin

    替马沙星,TMFX; TA-167 free acid; A-62254 free acid

     A DNA topoisomerase inhibitor
  13. GC44809 Rebeccamycin

    蝴蝶霉素

     A DNA topoisomerase I inhibitor
  14. GC44651 Pixantrone (maleate)

    马来酸匹衫琼; BBR 2778

     A DNA topoisomerase II inhibitor
  15. GC43565 Doxorubicinol (hydrochloride)

    13-Dihydroadriamycin hydrochloride

     A doxorubicin metabolite
  16. GC42912 Becatecarin

    NSC 655649; BMS 181176; BMY 27557

     A water-soluble antineoplastic antibiotic
  17. GC42783 Ametantrone

    阿美蒽醌,NSC 196473; NSC 290813

     An inhibitor of topoisomerase II
  18. GC41643 9(Z),11(E),13(E)-Octadecatrienoic Acid

    αEleostearic Acid, αESA, LAF 237

     A polyunsaturated fatty acid
  19. GC40195 Etoposide-d3

    EPE-d3, VP-16-123-d3

     An internal standard for the quantification of etoposide
  20. GC34169 Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride)

    AQ4N-d12 dihydrochloride

     Banoxantrone-d12 (AQ4N-d12) dihydrochloride 是氘标记的 Banoxantrone dihydrochloride。 Banoxantrone 是一种新型生物还原剂，可以还原为稳定的 DNA 亲和化合物 AQ4，它是一种有效的拓扑异构酶 II 抑制剂。
  21. GC34156 Namitecan (ST-1968)

    ST-1968

     Namitecan (ST-1968) 是一种有效的拓扑异构酶 I 抑制剂，具有抗肿瘤特性。
  22. GC34144 Karenitecin (Cositecan)

    (4S)-4-乙基-4-羟基-11-(2-三甲基硅基)乙基)-1H-吡喃并[3',4':6,7]氮茚并[1,2-B]喹啉-3,14(4H,12H)-二酮,Cositecan; BNP 1350

     Karenitecin (Cositecan) (Cositecan) 是一种拓扑异构酶 I 抑制剂，具有有效的抗癌活性。
  23. GC34085 Banoxantrone dihydrochloride (AQ4N dihydrochloride)

    AQ4N dihydrochloride

     Banoxantrone dihydrochloride (AQ4N dihydrochloride) 是一种缺氧活化拓扑异构酶 II 抑制剂，AQ4N 以非共价方式与 DNA 结合，促进缺氧和缺氧肿瘤细胞的抗肿瘤活性。
  24. GC33389 LMP744 (MJ-III65)

    MJ-III65; NSC706744

     LMP744 (MJ-III65) (MJ-III65) 是一种 DNA 嵌入剂和拓扑异构酶 I (Top1) 抑制剂，具有抗肿瘤活性。
  25. GC33240 Banoxantrone D12 (AQ4N D12)

    AQ4N D12

    Banoxantrone D12 (AQ4N D12) 是氘标记的banoxantrone。 Banoxantrone 是一种新型生物还原剂，可以还原为稳定的 DNA 亲和化合物 AQ4，它是一种有效的拓扑异构酶 II 抑制剂。
  26. GC33205 Indotecan (LMP-400)

    LMP-400; NSC-724998

     Indotecan (LMP-400) (LMP-400) 是一种有效的拓扑异构酶 1(Top1) 抑制剂，对 P388、HCT116、MCF-7 细胞系的 IC50 值分别为 300、1200、560 nM。
  27. GC33202 LMP744 hydrochloride (MJ-III65 hydrochloride)

    MJ-III65 hydrochloride; NSC706744 hydrochloride

     LMP744 hydrochloride (MJ-III65 hydrochloride) (MJ-III65 hydrochloride) 是一种 DNA 嵌入剂和拓扑异构酶 I (Top1) 抑制剂，具有抗肿瘤活性。
  28. GC33165 Intoplicine

    茚托利辛; RP 60475

     Intoplicine是DNA拓扑异构酶I和II抑制剂。
  29. GC33143 Podocarpusflavone A

    竹柏双黄酮 A；罗汉松双黄酮A

    A biflavone with diverse biological activities
  30. GC33128 Edotecarin (J 107088)

    J 107088; PF 804950

     Edotecarin (J 107088) 是一种有效的拓扑异构酶 I 抑制剂，可诱导单链 DNA 切割，IC50 为 50 nM。
  31. GC33127 TAS-103 (BMS-247615)

    BMS-247615

     TAS-103 (BMS-247615) 是 DNA 拓扑异构酶 I/II 的双重抑制剂，用于癌症研究。
  32. GC33108 Exatecan (DX-8951)

    依喜替康; DX-8951

    Exatecan (DX-8951) is a nonprodrug camptothecin (CPT) derivative, exhibits significant topoisomerase I inhibition.
  33. GC33066 Belotecan hydrochloride (CKD-602)

    CKD-602盐酸盐,CKD-602

     A DNA topoisomerase I inhibitor
  34. GC32926 Dxd (Exatecan derivative)

    DX-8951衍生物,Exatecan derivative for ADC

     DXd 是 Exatecan (DX-8951) 的衍生物。
  35. GC32822 TAS-103 dihydrochloride (BMS-247615 dihydrochloride)

    6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐,BMS-247615 dihydrochloride

     A DNA topoisomerase I and II inhibitor
  36. GC32714 Mitoxantrone (mitozantrone)

    米托蒽醌; Mitozantrone; NSC 301739

     米托蒽醌Mitoxantrone是一种抗肿瘤的蒽醌衍生物。
  37. GC32088 Gepotidacin (GSK2140944)

    GSK2140944

     Gepotidacin (GSK2140944) (GSK2140944) 是一种新型三氮杂苊细菌 II 型拓扑异构酶抑制剂。
  38. GC19342 SW044248 A DNA topoisomerase I inhibitor
  39. GC19148 Exatecan Mesylate

    依喜替康甲磺酸盐; DX8951f

     A DNA topoisomerase I inhibitor
  40. GC19073 Bisantrene

    比生群; CL216942

     Bisantrene 是一种高效的抗肿瘤药物，靶向真核生物 II 型拓扑异构酶。
  41. GC18751 Reticulol

    网状菌醇

     A cAMP phosphodiesterase and DNA topoisomerase I inhibitor
  42. GC18536 Chartreusin

    教酒菌素

     An antibiotic with diverse biological activites
  43. GC11903 9-amino Camptothecin

    9-氨基喜树碱; 9-amino-20(S)-camptothecin

     A DNA topoisomerase I inhibitor
  44. GC10779 Alternariol

    交链孢酚

     A mycotoxin
  45. GC12638 UK 1

    2'-(2-羟基苯基)-[2,4'-联苯并恶唑]-4-羧酸甲酯

     A cytotoxic Streptomyces metabolite
  46. GC15612 Luotonin A A cytotoxic alkaloid
  47. GC15336 Luotonin F A plant alkaloid with anticancer activity
  48. GC15399 Dp44mT

    2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺

     An iron chelator with antiproliferative effects
  49. GC17833 Topotecan

    拓扑替康; SKF 104864A; NSC 609669

     Topotecan (SKF 104864A; NSC 609669) 是一种口服有效的拓扑异构酶 I 抑制剂。 Topotecan 在 G0/G1 和 S 期诱导细胞周期停滞并促进细胞凋亡。拓扑替康显示出抗癌活性。
  50. GC10098 (S)-10-Hydroxycamptothecin

    10-羟基喜树碱; 10-HCPT; 10-Hydroxycamptothecin

     A DNA topoisomerase I inhibitor
  51. GC15305 Ellipticine

    椭圆玫瑰树碱,NSC 71795

     Ellipticine (NSC 71795) 是一种有效的抗肿瘤剂；抑制 DNA 拓扑异构酶 II 的活性。

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