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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> Topoisomerase

Topoisomerase(拓扑异构酶)

Topoisomerase are enzymes that regulate the overwinding or underwinding of DNA.

Products for  Topoisomerase

  1. Cat.No. 产品名称 Information
  2. GC12503 Pixantrone

    匹杉琼; BBR 2778 free base

     A DNA topoisomerase II inhibitor
  3. GC17082 Pirarubicin

    吡柔比星; THP

     An anthracycline antitumor antibiotic
  4. GC14363 Mitoxantrone HCl

    米托蒽醌二盐酸盐; Mitozantrone dihydrochloride; NSC 301739 dihydrochloride

     An inhibitor of DNA topoisomerase IIα and HIV-1 integrase
  5. GC16455 Flumequine

    氟甲喹; R-802

     A fluoroquinolone antibiotic
  6. GC11048 Irinotecan HCl Trihydrate

    盐酸伊立替康三水合物; (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate

     A potent inhibitor of DNA topoisomerase I
  7. GC13359 Topotecan HCl

    盐酸拓扑替康; SKF 104864A Hydrochloride; NSC 609669 Hydrochloride

     A potent inhibitor of DNA topoisomerase I
  8. GC11747 Amsacrine hydrochloride

    盐酸胺苯吖啶,m-AMSA hydrochloride; acridinyl anisidide hydrochloride

     A topoisomerase II poison
  9. GC12326 Amsacrine

    安吖啶; m-AMSA; acridinyl anisidide

     A topoisomerase II poison
  10. GC12828 Daunorubicin

    柔红霉素; Daunomycin; RP 13057; Rubidomycin

    Daunorubicin (Daunomycin) 是一种拓扑异构酶 II 抑制剂，具有有效的抗肿瘤活性。
  11. GC10354 Daunorubicin HCl

    盐酸柔红霉素; Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride

     Antitumor antibiotic used in the treatment of acute myeloid leukemias
  12. GC10734 Beta-Lapachone

    3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,ARQ-501; NSC-26326

     An anti-cancer quinone
  13. GC16084 Teniposide

    替尼泊苷; VM26

     A topoisomerase II poison
  14. GC12292 Ofloxacin

    氧氟沙星; Hoe-280

     A fluoroquinolone antibiotic
  15. GC11114 Moxifloxacin HCl

    莫西沙星盐酸盐; BAY 12-8039

     A fluoroquinolone antibiotic
  16. GC11619 Dexrazoxane HCl (ICRF-187, ADR-529)

    右雷佐生盐酸盐; ICRF-187 hydrochloride; ADR-529 hydrochloride; NSC-169780 hydrochloride

     Topoisomerase IIα inhibitor and intracellular ion chelator
  17. GC11473 Irinotecan

    伊立替康; (+)-Irinotecan; CPT-11

     Irinotecan是一种拓扑异构酶抑制剂，主要用于治疗结直肠癌。Irinotecan可通过与拓扑异构酶 I-DNA 复合物结合，阻止 DNA 链的再连接，并导致 DNA 双链断裂和细胞死亡 。
  18. GC10686 Epirubicin HCl

    盐酸表柔比星; 4'-Epidoxorubicin hydrochloride

    An anthracycline antitumor antibiotic
  19. GC11019 Amonafide

    氨萘非特; AS1413

     A DNA-intercalating topoisomerase II poison
  20. GC14969 Idarubicin HCl

    盐酸伊达比星; 4-Demethoxydaunorubicin hydrochloride

     Antitumor antibiotic used in treatment of leukemia
  21. GC15617 Etoposide

    依托泊苷; VP-16; VP-16-213

     Etoposide（VP-16）是一种非特异性拓扑异构酶II（Topoisomerase II）抑制剂，IC50值为59.2 μM。
  22. GC15548 Ellagic acid

    鞣花酸

     Polyphenolic antioxidant
  23. GC14102 Genistein

    染料木素; NPI 031L

     染料木黄酮是一种异黄酮，属于类黄酮化合物，存在于多种植物中。
  24. GC14376 Gatifloxacin

    加替沙星; AM-1155; BMS-206584; PD135432

     A fluoroquinolone antibiotic
  25. GC15439 Camptothecin

    喜树碱; Campathecin; (S)-(+)-Camptothecin; CPT

     Camptothecin是一种特异性DNA拓扑异构酶I（Top1）抑制剂，IC50值为679 nM。
  26. GC17567 Doxorubicin (Adriamycin) HCl

    盐酸阿霉素; Hydroxydaunorubicin hydrochloride

    An anthracycline antitumor antibiotic
  27. GC15644 Amrubicin

    氨柔比星,SM-5887

     Amrubicin (SM-5887) 是一种 DNA 拓扑异构酶 II 抑制剂，用于癌症研究。
  28. GC16994 Doxorubicin

    阿霉素; Hydroxydaunorubicin

     多柔比星（Doxorubicin，简称DOX），也被称为阿霉素，是一种蒽环类化合物，具有最广泛的活性谱。
  29. GC14022 Voreloxin Hydrochloride

    (3S-反式)-1,4-二氢-7-[3-甲氧基-4-(甲基氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸单盐酸盐,SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride

     Voreloxin Hydrochloride 是一流的拓扑异构酶 II 抑制剂，可嵌入 DNA 并诱导位点选择性 DNA DSB、G2 停滞和细胞凋亡。
  30. GC13544 Voreloxin

    SNS-595; Vosaroxin; AG 7352

     An inhibitor of topoisomerase II
  31. GC11298 TH-302

    N,N'-双(2-溴乙基)二氨基膦酸(1-甲基-2-硝基-1H-咪唑-5-基)甲酯,TH 302,TH302,HAP-302,HAP302

     A hypoxia-activated anticancer agent
  32. GC15853 Genz-644282

    Genz644282;Genz 644282

     An inhibitor of topoisomerase I
  33. GC15250 DOXO-EMCH

    INNO-206;Doxorubicin-EMCH;INNO 206

     Prodrug of doxorubicin
  34. GC17412 Deferasirox Fe3+ chelate

    地拉罗斯铁螯合物

     Deferasirox Fe3+ Chelate 是从专利 WO2003053986 中提取的铁螯合剂。
  35. GC11175 Daun02

    (8S,10S)-8-乙酰基-7,8,9,10-四氢-6,8,11-三羟基-1-甲氧基-10-[[2,3,6-三脱氧-3-[[[[4-(BETA-D-吡喃半乳糖基氧基)-3-硝基苯基]甲氧基]羰基]氨基]-ALPHA-L-来苏-己糖吡喃糖苷]氧基]-5,12-并四苯醌,Daun 02; Daun-02

     Daun02 是拓扑异构酶抑制剂柔红霉素的前药。
  36. GC10480 Betulinic acid

    白桦脂酸; Lupatic acid; Betulic acid

     白桦脂酸（Betulinic acid）是一种天然的五环三萜类化合物，是真核细胞拓扑异构酶I的抑制剂，IC50值为5μM。
  37. GC17271 4'-Demethylepipodophyllotoxin

    4'-去甲基表鬼臼毒素; 4'-O-demethylepipodophyllotoxin; 4'-DMEP

     An inhibitor of tubulin polymerization
  38. GN10523 Berberine Sulfate

    硫酸小檗碱,Natural Yellow 18 sulfate

    硫酸小檗碱是一种从中草药黄连中分离出来的生物碱，作为一种抗生素。
  39. GN10449 SN-38 (NK012)

    7-乙基-10-羟基喜树碱,7-Ethyl-10-hydroxycamptothecin

     A potent inhibitor of DNA topoisomerase I
  40. GN10035 9-Methoxycamptothecin

    10-甲氧基喜树碱

     9-Methoxycamptothecin (MCPT) 分离自 Nothapodytes foetida，通过抑制拓扑异构酶具有抗肿瘤活性。 9-Methoxycamptothecin (MCPT) 在癌症中诱导强烈的 G2/M 期阻滞和细胞凋亡。
  41. GN10416 Podophyllotoxin

    鬼臼毒素,Condyline; Condylox; Podofilox

     A lignan with diverse biological activities
  42. GN10208 Berberine hydrochloride

    盐酸小檗碱; Natural Yellow 18 chloride

     盐酸小檗碱是来源于毛茛科药用植物黄连的一种异喹啉类生物碱，具有抗肿瘤、抗炎、降血糖等多种药理活性。
  43. GN10221 Berberine

    黄连素; Natural Yellow 18

    小檗碱（Natural Yellow 18）是一种从中草药黄连中分离出来的生物碱，作为一种抗生素。

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