Endocrinology and Hormones(内分泌和激素)

Endocrinology and Hormones

The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more

Products for Endocrinology and Hormones

Cat.No. 产品名称 Information
GC63072 Methyl-6-alpha-Naltrexol
Methyl-6-alpha-Naltrexol 是甲基纳曲酮 (MNTX) 的代谢物 (metabolite)。Methyl-6-alpha-Naltrexol 是一种选择性的 mu-阿片受体 (mu-opioid receptor) 拮抗剂，在胃肠道组织中起外周作用的受体拮抗剂作用。
GC63066 Methenolone acetate
美替诺龙醋酸酯,Methenolone acetate

Metenolone醋酸盐是一种长效的蛋白同化激素，具有较低的雄激素特性。IC50 value:Target:Metenolone醋酸盐是一种天然存在的化合物，在驯养的怀孕猫科肾上腺腺体内发现。Metenolone醋酸盐用于口服给药。Methenolone醋酸盐可抑制下丘脑 - 垂体 - 性腺通路。[1] Methenolone醋酸盐作为口服制剂时，Methenolone不是17-α-烷基化，而是1-甲基化，便于提高口服生物利用度，且降低肝脏应力。[2]
GC62992 Glutaurine
磺乙谷酰胺,Litoralon
A dipeptide
GC62761 1α-Hydroxy-3-epi-vitamin D3 1α-Hydroxy-3-epi-vitamin D3 是 1alpha,25-dihydroxyvitamin D3 的天然代谢物，是甲状旁腺激素 (?PTH?) 分泌的有效抑制剂
GC49427 3,5-Diiodo-L-thyronine
3,5-二碘-L-甲状腺素,3,5-Diiodo-L-thyronine
A thyroid hormone metabolite
GC49423 Metanephrine-d3 (hydrochloride)
DL-Metanephrine-d3
An internal standard for the quantification of metanephrine
GC49408 Ramipril Diketopiperazine Acid
雷米普利杂质K
A potential impurity found in commercial preparations of ramipril
GC49399 N-Desbutyl Dronedarone (hydrochloride)
N-[2-丁基-3-[4-[3-(丁基氨基)丙氧基]苯甲酰基]-5-苯并呋喃基]甲磺酰胺盐酸盐,SR35021 hydrochloride
An active metabolite of dronedarone
GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid
GC49391 7α-Thiospironolactone
Deacetylspironolactone, Mercaptospironolactone, SC-24813, 7α-Thio-SL
An active metabolite of spironolactone
GC49389 Tritylolmesartan Medoxomil
三苯甲基奥美沙坦酯
An intermediate in the synthesis of olmesartan medoxomil
GC49385 Halometasone
卤米松
A synthetic corticosteroid
GC49342 Glucagon-d9 (trifluoroacetate salt) An internal standard for the quantification of glucagon
GC49329 Turkesterone (hydrate) A phytoecdysteroid with diverse biological activities
GC49326 5β-Dihydroprogesterone
5Β-二氢孕酮
A progesterone receptor agonist and metabolite of progesterone
GC49321 AZ-GHS-22 An inverse agonist of GHS-R1a
GC49306 Isopimaric Acid
异海松酸
A diterpenoid resin acid
GC49303 Ganoderic Acid DM
灵芝酸 DM
A triterpenoid with diverse biological activities
GC49254 Estrone-3-Glucuronide (sodium salt hydrate)
E1G, Estrone Glucuronide, Estrone β-D-Glucuronide
A metabolite of 17β-estradiol
GC49207 Lumisterol 3
光甾醇 3; 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C
A photoisomer of previtamin D₃
GC49206 7α-hydroxy Dehydroepiandrosterone
7-羟基去氢表雄酮
An active metabolite of dehydroepiandrosterone
GC49189 (E/Z)-4-hydroxy Tamoxifen-d5
Afimoxifene-d5, 4-OHT-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
GC49180 3-epi-25-hydroxy Vitamin D3
3-EPI-25-羟基维生素D3
The C-3 epimer of 25-hydroxy vitamin D₃
GC49176 5β-Tetrahydrocortisol
NSC 57431
An endogenous metabolite of cortisol
GC49172 2-hydroxy Estrone
2-羟雌甾酮,Catecholestrone
An active metabolite of estrone
GC49161 16α-hydroxy Dehydroepiandrosterone
16α-hydroxy DHEA
A metabolite of dehydroepiandrosterone
GC49143 Deslorelin (acetate)
D-Trp6-Pro9-des-Gly10-GnRH ethylamide, pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt
A peptide agonist of GnRH
GC49123 Somatorelin (1-44) amide (human) (trifluoroacetate salt)
Growth Hormone-releasing Factor (1-44) amide, hpGRF-44, Human Pancreas GRF-44, Somatoliberin
A synthetic GHRH peptide
GC49108 Racecadotril-d5
消旋卡多曲杂质,Acetorphan-d5
An internal standard for the quantification of racecadotril
GC49068 16-Epiestriol
异雌三醇,16-epi-Estriol; 16β,17β-Estriol
A metabolite of estrone
GC49055 Tebuconazole-d9
戊唑醇 d9
An internal standard for the quantification of tebuconazole
GC49048 Guanylin (human) (trifluoroacetate salt) A peptide hormone activator of GC-C
GC49025 Desogestrel-13C2-d2 An internal standard for the quantification of desogestrel
GC49012 Tauro-β-muricholic Acid-d4 (sodium salt)
Tauro-β-muricholate-d4, TβMCA-d4
tauro-β-muricholic acid 定量的内标
GC49011 Tauro-α-muricholic Acid-d4 (sodium salt)
Tauro-β-muricholate-d4, TβMCA-d4
An internal standard for the quantification of tauro-α-muricholic acid
GC48981 Senktide (trifluoroacetate salt) A potent NK3 receptor agonist
GC48979 Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
E217G, βEstradiol 17(βDGlucuronide), 17βEstradiol 17(βDGlucuronide), 17βOestradiol 17(βDGlucuronide)
A substrate of multidrug resistance protein 2
GC62683 Ralaniten
EPI-002
Ralaniten (EPI-002) 是一种有效和具有口服活性的雄激素受体 N 端结构域 (AR-NTD) 拮抗剂。Ralaniten 抑制 AR 转录活性，IC50 值为 7.4 μM。Ralanites 可用于去势抵抗性前列腺癌 (CRPC) 的研究。
GC62644 GnRH antagonist 2 GnRH antagonist 2 (formula I) 是一种 GnRH 受体拮抗剂，可用于子宫内膜异位的研究。
GC62603 Ralaniten triacetate
EPI-506
Ralaniten triacetate (EPI-506) 是 Ralaniten 的前药，是一种首创的，具有口服活性的雄激素受体 (AR) N 端结构域 (NTD) 抑制剂。Ralaniten triacetate 对全长和与抗性相关的 AR 物种，包括 AR-v7 都有活性。
GC62329 VPC-14449 VPC-14449 是一种有效和选择性的雄激素受体 DNA 结合结构域 (AR-DBD) 抑制剂，对全长人 AR 的 IC50 值为 0.34 μM。VPC-14449 可降低全长 AR 以及 AR 变体与染色质相互作用的能力。VPC-14449 可用于前列腺癌的研究。
GC62249 Honokiol DCA
Honokiol dichloroacetate
Honokiol DCA (Honokiol dichloroacetate) 是 Honokiol 的二氯乙酸酯类似物。Honokiol DCA 在体外可以抑制人前列腺癌细胞的生长并抑制雄激素受体 (AR) 蛋白水平。
GC62209 CLP-3094
2-[2-(4-氯-苯氧基)-乙基硫基]-1H-苯并咪唑
CLP-3094, a potent inhibitor targeting the binding function 3 (BF3) site of androgen receptor (AR), inhibits AR transcriptional activity with IC50 of 4 μM, also is a selective, potent GPR142 antagonist.
GC62124 UT-34 UT-34 is a potent, selective and orally bioavailable second-generation androgen receptor (AR) pan antagonist and degrader with IC50 of 203.46 nM, 80.78 nM and 94.17 nM for wild-type, T877A and W741L AR, respectively. UT-34 is a potential next-generation therapeutic for enzalutamide-resistant prostate cancer.
GC62118 ARV-110
ARV-110
Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.
GC62106 JNJ-63576253
TRC-253
JNJ-63576253 (TRC-253) is a potent and selective androgen receptor (AR) Antagonist with IC50 of 6.9 nM. JNJ-63576253 displays robust inhibition in WT and LBD-mutated, enzalutamide-resistant models of prostate cancer.
GC19802 Octreotide acetate
奥曲肽; SMS 201-995
A somatostatin receptor agonist
GC62061 Melengestrol acetate
醋酸美伦孕酮
A synthetic progestogen
GC61971 Liarozole
利阿唑,R75251
A CYP26A1 inhibitor
GC61954 Deltorphin 2 TFA
[D-Ala2]-Deltorphin II TFA
Deltorphin 2 TFA 是一种选择性的 δ 阿片受体肽激动剂。