Endocrinology and Hormones(内分泌和激素)

Endocrinology and Hormones

The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more

Products for Endocrinology and Hormones

Cat.No. 产品名称 Information
GC49161 16α-hydroxy Dehydroepiandrosterone
16α-hydroxy DHEA
A metabolite of dehydroepiandrosterone
GC49143 Deslorelin (acetate)
D-Trp6-Pro9-des-Gly10-GnRH ethylamide, pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt
A peptide agonist of GnRH
GC49123 Somatorelin (1-44) amide (human) (trifluoroacetate salt)
Growth Hormone-releasing Factor (1-44) amide, hpGRF-44, Human Pancreas GRF-44, Somatoliberin
A synthetic GHRH peptide
GC49108 Racecadotril-d5
消旋卡多曲杂质,Acetorphan-d5
An internal standard for the quantification of racecadotril
GC49068 16-Epiestriol
异雌三醇,16-epi-Estriol; 16β,17β-Estriol
A metabolite of estrone
GC49055 Tebuconazole-d9
戊唑醇 d9
An internal standard for the quantification of tebuconazole
GC49048 Guanylin (human) (trifluoroacetate salt) A peptide hormone activator of GC-C
GC49025 Desogestrel-13C2-d2 An internal standard for the quantification of desogestrel
GC49012 Tauro-β-muricholic Acid-d4 (sodium salt)
Tauro-β-muricholate-d4, TβMCA-d4
tauro-β-muricholic acid 定量的内标
GC49011 Tauro-α-muricholic Acid-d4 (sodium salt)
Tauro-β-muricholate-d4, TβMCA-d4
An internal standard for the quantification of tauro-α-muricholic acid
GC48981 Senktide (trifluoroacetate salt) A potent NK3 receptor agonist
GC48979 Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
E217G, βEstradiol 17(βDGlucuronide), 17βEstradiol 17(βDGlucuronide), 17βOestradiol 17(βDGlucuronide)
A substrate of multidrug resistance protein 2
GC62683 Ralaniten
EPI-002
Ralaniten (EPI-002) 是一种有效和具有口服活性的雄激素受体 N 端结构域 (AR-NTD) 拮抗剂。Ralaniten 抑制 AR 转录活性，IC50 值为 7.4 μM。Ralanites 可用于去势抵抗性前列腺癌 (CRPC) 的研究。
GC62644 GnRH antagonist 2 GnRH antagonist 2 (formula I) 是一种 GnRH 受体拮抗剂，可用于子宫内膜异位的研究。
GC62603 Ralaniten triacetate
EPI-506
Ralaniten triacetate (EPI-506) 是 Ralaniten 的前药，是一种首创的，具有口服活性的雄激素受体 (AR) N 端结构域 (NTD) 抑制剂。Ralaniten triacetate 对全长和与抗性相关的 AR 物种，包括 AR-v7 都有活性。
GC62329 VPC-14449 VPC-14449 是一种有效和选择性的雄激素受体 DNA 结合结构域 (AR-DBD) 抑制剂，对全长人 AR 的 IC50 值为 0.34 μM。VPC-14449 可降低全长 AR 以及 AR 变体与染色质相互作用的能力。VPC-14449 可用于前列腺癌的研究。
GC62249 Honokiol DCA
Honokiol dichloroacetate
Honokiol DCA (Honokiol dichloroacetate) 是 Honokiol 的二氯乙酸酯类似物。Honokiol DCA 在体外可以抑制人前列腺癌细胞的生长并抑制雄激素受体 (AR) 蛋白水平。
GC62209 CLP-3094
2-[2-(4-氯-苯氧基)-乙基硫基]-1H-苯并咪唑
CLP-3094, a potent inhibitor targeting the binding function 3 (BF3) site of androgen receptor (AR), inhibits AR transcriptional activity with IC50 of 4 μM, also is a selective, potent GPR142 antagonist.
GC62124 UT-34 UT-34 is a potent, selective and orally bioavailable second-generation androgen receptor (AR) pan antagonist and degrader with IC50 of 203.46 nM, 80.78 nM and 94.17 nM for wild-type, T877A and W741L AR, respectively. UT-34 is a potential next-generation therapeutic for enzalutamide-resistant prostate cancer.
GC62118 ARV-110
ARV-110
Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.
GC62106 JNJ-63576253
TRC-253
JNJ-63576253 (TRC-253) is a potent and selective androgen receptor (AR) Antagonist with IC50 of 6.9 nM. JNJ-63576253 displays robust inhibition in WT and LBD-mutated, enzalutamide-resistant models of prostate cancer.
GC19802 Octreotide acetate
奥曲肽; SMS 201-995
A somatostatin receptor agonist
GC62061 Melengestrol acetate
醋酸美伦孕酮
A synthetic progestogen
GC61971 Liarozole
利阿唑,R75251
A CYP26A1 inhibitor
GC61954 Deltorphin 2 TFA
[D-Ala2]-Deltorphin II TFA
Deltorphin 2 TFA 是一种选择性的 δ 阿片受体肽激动剂。
GC61850 Medroxyprogesterone acetate D3
醋酸甲羟孕酮 D3; Medroxyprogesterone 17-acetate-d3; Farlutin-d3
Medroxyprogesterone acetate D3 是 Medroxyprogesterone acetate 的氘代物。Medroxyprogesterone acetate 是一种广泛使用的合成类固醇，与孕酮 (progesterone)，雄激素 (androgen) 和糖皮质激素受体 (glucocorticoid receptors) 都有作用。
GC61586 UFP-101 TFA UFP-101TFA是一种强效、选择性和竞争性的NOP受体拮抗剂，pKi为10.24。UFP-101TFA对δ、μ和κ类阿片受体的选择性大于3000倍。UFP-101TFA具有抗抑郁药样作用。
GC61491 (R)-Bicalutamide
(R)-比卡鲁胺
(R)-Bicalutamide是Bicalutamide的R型对映体。(R)-Bicalutamide是一种雄激素受体(AR)拮抗剂，具有抗肿瘤活性。(R)-Bicalutamide广泛用于前列腺癌的研究。
GC61484 β-Casomorphin, human TFA
Human β-casomorphin 7 TFA
β-Casomorphin,humanTFA(Humanβ-casomorphin7TFA)是一种阿片样肽，作为opioid受体激动剂。
GC61481 PROTAC AR Degrader-4 TFA PROTACARDegrader-4包含cIAP1配体结合基团，linker和雄激素受体(AR)配体结合基团。基于cIAP1的降解剂也被称为SNIPER。
GC61397 Asimadoline hydrochloride
阿西马朵林盐酸盐; EMD-61753 hydrochloride
A potent κ-opioid receptor agonist
GC48937 L-Tyrosine-13C9,15N
DL-酪氨酸 13C9,15N
An internal standard for the quantification of L-tyrosine
GC48910 2-Hydroxyanthraquinone
2-羟基蒽醌
An anthraquinone with antibacterial and estrogenic activities
GC48880 7-Methoxyflavone
7-甲氧基黄酮
A flavone with diverse biological activities
GC48831 Flutamide-d7
SCH 13521-d7
Flutamide-d7 是氘标记的氟他胺。
GC48824 4-hydroxy Estrone
4-羟基雌酮; 4-OHE1
A metabolite of estrone
GC48819 17-Epiestriol
17-环雌三醇
A metabolite of estrone
GC48808 5β-Androstane-3α,17β-diol
5β-Adiol, 5β-Androstanediol, β-Androstane-3α,17β-diol, Etiocholanediol
A metabolite of testosterone
GC48803 Norethynodrel
异炔诺酮,Enidrel; SC 4642; NSC 15432
A synthetic progestin
GC48788 Norethindrone-d6
炔诺酮D6,Norethisterone-d6
An internal standard for the quantification of norethindrone
GC48787 11β-Hydroxyetiocholanolone
11Β-羟基本胆烷醇酮
A metabolite of hydrocortisone
GC48763 Gestodene-d6
SHB 331-d6; WL 70-d6
An internal standard for the quantification of gestodene
GC48735 2-methyl AP-237-d7 (hydrochloride)
2-methyl Buccinazine-d7
An Analytical Reference Standard
GC48724 Pregnanetriol
孕三醇
A metabolite of 17α-hydroxyprogesterone
GC48710 11-Dehydrocorticosterone
11-去氫皮質甾酮,11-DHC
An endogenous mineralocorticoid
GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine
GC48610 GSK3987 A dual agonist of LXRα and LXRβ
GC48496 Clobetasol Propionate-d5
CCI-4725-d5, CGP 9555-d5, Clobetasol 17-propionate-d5
An internal standard for the quantification of clobetasol propionate
GC48432 KB-130015
KB015
An antiarrhythmic agent
GC48426 CAY10771 A dual agonist of FXR and PPARδ