Endocrinology and Hormones(内分泌和激素)

Endocrinology and Hormones

The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more

Products for Endocrinology and Hormones

Cat.No. 产品名称 Information
GC36778 N-terminally acetylated Leu-enkephalin
Ac-L-Tyr-Gly-Gly-L-Phe-D-Leu-COOH
N-terminally acetylated Leu-enkephalin 是N-末端乙酰化的 Leu-enkephalin。Leu-enkephalin是一种五氨基酸的内源性肽，作为阿片受体的激动剂。
GC36689 Nalfurafine hydrochloride
盐酸纳呋拉啡; TRK-820 hydrochloride
An Analytical Reference Standard
GC36621 MK-0773
PF-05314882
MK-0773 是一种选择性雄激素受体调节剂 (selective androgen receptor modulators)，与 AR 结合，IC50 值为 6.6 nM。
GC36562 MCOPPB triHydrochloride
MCOPPB 3HCl
MCOPPB 3Hcl 是一种伤害感受肽受体激动剂，pKi为10.07；其他阿片受体的活性较弱。
GC36508 LY-2940094
BTRX-246040
LY-2940094 是一种口服有效的选择性 nociceptin 受体 (NOP 受体) 拮抗剂，对 NOP 受体具有高亲和力(Ki 为 0.105 nM) 和拮抗活力 (Kb=0.166 nM)。LY-2940094 可降低动物模型的自身给药酒精依赖。
GC36499 LXRβ agonist-2 LXRβ agonist-2 是一种高效 β 选择性肝 X 受体 (LXRβ) 激动剂，EC50为 7 nM，其选择性是 LXRα (EC50=200 nM) 的 28.5 倍，用于治疗动脉粥样硬化。
GC36487 L-Thyroxine sodium salt pentahydrate
L-甲状腺素钠五水合物; Sodium levothyroxine pentahydrate
A synthetic form of thyroxine
GC36479 Loperamide hydrochloride
盐酸洛哌丁胺; R-18553 hydrochloride
An Analytical Reference Standard
GC36465 Liothyronine An thyroid hormone which binds to TRβ1, and activates its activity
GC36344 Isosilybin B
异水飞蓟宾B
Isosilybin B，一种从 silymarin 中分离的黄酮木脂素，具有抗前列腺癌 (PCA) 活性，抑制癌细胞增殖，诱导 G1 期阻滞和凋亡。Isosilybin B 引起雄激素受体降解。
GC36180 Goserelin acetate
醋酸戈舍瑞林; ICI-118630 acetate
A synthetic GNRH agonist
GC35986 Endomorphin 2 TFA
内吗啡肽 2 三氟乙酸盐
Endomorphin 2 TFA，一种高度选择性的高亲和力 μ-opioid 受体激动剂，对 kappa3 结合位点具有高亲和力，Ki 为 20 到 30 nM 之间。
GC35919 Dynorphin B (1-13) (TFA)
强啡肽 B (1-13) 三氟乙酸盐
Dynorphin B (1-13) TFA 是一种阿片样 κ 受体 (κ-opioid receptor) 激动剂。
GC35918 Dynorphin A 1-10 Dynorphin A (1-10) 是一种内源性的阿片样神经肽，与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) 也阻断 NMDA 激活的电流，IC50 为 42.0 μM。
GC35917 Dynorphin A (1-10) TFA Dynorphin A (1-10) (TFA) 是一种内源性的阿片样神经肽，与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) (TFA) 也阻断 NMDA 激活的电流，IC50 为 42.0 μM。
GC35828 Degarelix
地加瑞克
A synthetic GNRHR antagonist
GC35805 DAMGO (TFA) DAMGO (DAGO) is a potent and selective μ opioid receptor agonist with ki of 17 nM.
GC35638 Cebranopadol ((1α,4α)stereoisomer)
GRT6005 (1α,4α)stereoisomer
Cebranopadol (1α,4α)stereoisomer 是 cebranopadol 的立体异构体，活性较低。Cebranopadol 是 ORL-1 的有效激活剂。
GC35637 Cebranopadol
GRT6005

A nociceptin-, µ-, ĸ-, and δ-opioid receptor agonist
GC35541 Boldenone Undecylenate
宝丹酮十一烯酸酯
An Analytical Reference Standard
GC35534 BMS-564929 BMS-564929 是一种雄激素受体 (AR) 激动剂，结合到雄激素受体，Ki 为 2.11±0.16 nM。
GC35311 Alvimopan monohydrate
爱维莫潘水合物; ADL 8-2698 monohydrate; LY 246736 monohydrate
A μ-opioid receptor antagonist
GC35268 AGN 205728 AGN 205728是选择性RARγ拮抗剂，Ki/IC95分别为3 nM/ 0.6 nM，对RARα和RARβ无抑制性。
GC35267 AGN 205327 AGN 205327是RAR激动剂，对RARα/β/γ的EC50分别为3766/734/32 nM，对RXR无抑制性。
GC35266 AGN 196996 AGN 196996是高活性RARα选择性抑制剂，Ki为2 nM，对RARβ和RARγ的亲和性极低（Ki分别为1087 nM和8523 nM）。
GC35265 AGN 195183
IRX-5183; VTP-195183; NRX-195183
AGN 195183是RARα选择性激动剂，Kd为3 nM，相对于AGN 193836有更好的结合选择性，对RARβ/γ无活性。
GC35217 Abarelix Acetate
阿巴瑞克乙酸盐; PPI 149 Acetate; R 3827 Acetate
A synthetic GnRHR antagonist
GC35069 2,2,5,7,8-Pentamethyl-6-Chromanol
3,4-二氢-2,2,5,7,8-五甲基-2H-1-苯并吡喃-6-酚,PMC
2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) 是维生素 E (α-tocopherol) 的抗氧化部分。2,2,5,7,8-Pentamethyl-6-Chromanol 具有有效的雄激素受体 (androgen receptor) 信号调节和抗前列腺癌细胞系的抗癌活性。
GC35018 [Met5]-Enkephalin, amide TFA
5-Methionine-enkephalin amide TFA
[Met5]-Enkephalin, amide TFA 是一种 δ 和 ζ 阿片受体 (opioid receptor) 激动剂。
GC35017 [Leu5]-Enkephalin, amide
Leu-Enkephalin amide
[Leu5]-Enkephalin, amide 是一种 δ 阿片受体 (opioid receptor) 激动剂。
GC34965 (20S)-Protopanaxatriol
20 (S)-原人参三醇; 20(S)-APPT; g-PPT
An active ginsenoside metabolite
GC34960 (+)-Talarozole (+)-Talarozole 是视黄酸代谢的有效抑制剂，来自专利 WO 1997049704 A1。
GC19552 4-Hydroxyestradiol
4-羟雌二醇,4-Hydroxy-17β-estradiol
A catechol estrogen and minor metabolite of estrogen
GC45239 δ4-Abiraterone
阿比特龙代谢物,Δ4-Abiraterone; CB-7627; Abiraterone D4A metabolite
An active metabolite of abiraterone
GC45238 δ14-Triamcinolone acetonide
曲安奈德杂质1
A potential impurity found in commercial triamcinolone acetonide preparations
GC45236 β-Endorphin (rat)
Β-内啡肽,鼠
An opioid neuropeptide
GC45226 β-BHC
β-HCH, β-Hexachlorocyclohexane, β-Lindane
β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane.
GC45146 VIP (human, porcine, rat, ovine) (trifluoroacetate salt)
Vasoactive Intestinal Peptide
A peptide with diverse biological activities
GC45139 Vapreotide (trifluoroacetate salt)
BMY 41606, Octastatin, RC 160
A peptide NK₁ receptor antagonist
GC45129 Urocortin (human) (trifluoroacetate salt) A neuropeptide hormone
GC45001 Tazarotenic Acid
他扎罗汀酸,AGN 190299
An active metabolite of tazarotene
GC45000 Tauro-β-muricholic Acid (sodium salt)
牛磺-Α-鼠胆酸,Tauro-β-muricholate； TβMCA
An FXR receptor antagonist
GC44999 Tauro-α-muricholic Acid (sodium salt)
Tauro-α-muricholate, TαMCA
An FXR receptor antagonist
GC44998 Tauro-Obeticholic Acid
奥贝胆酸杂质9
An active metabolite of obeticholic acid
GC44914 Somatostatin-14 (acetate) A cyclic peptide hormone
GC44861 S-23
(S)-2-(芴甲氧羰基)-3-联苯基氨基丙酸
A selective androgen receptor modulator
GC44812 Renin Fluorogenic Substrate A probe for renin activity
GC44693 Progesterone-3-biotinyl Photoaffinity Probe
P4, P4 Binding Probe
A photoaffinity probe
GC44692 Progesterone 3-PEG11-biotin A hydrophilic affinity probe
GC44691 Progesterone 3-biotin An affinity probe