Androgen Receptor(雄激素受体)

Cat.No. 产品名称 Information

GC47562 Levonorgestrel-d6 A neuropeptide with diverse biological activities

GC47554 Letrozole-d4

来曲唑 d4

An internal standard for the quantification of letrozole

GC47231 Dimethomorph

烯酰吗啉

A morpholine fungicide

GC47215 Dienogest-d8 An internal standard for the quantification of dienogest

GC47159 Cyprodinil

嘧菌环胺

An anilinopyrimidine fungicide

GC46925 Bicalutamide-d4

比卡鲁胺 d4

An internal standard for the quantification of bicalutamide

GC46777 AC-262536

4-(3-内型-羟基-8-氮杂双环[3.2.1]辛烷-8-基)萘-1-甲腈

A selective androgen receptor modulator

GC46775 Abiraterone Acetate-d4

CB7630-d4

醋酸阿比特龙-d4 (CB7630-d4) 是氘标记的醋酸阿比特龙。醋酸阿比特龙 (CB7630) 是一种口服的、有效的、选择性的、不可逆的 CYP17A1 抑制剂，具有抗雄激素活性。醋酸阿比特龙是阿比特龙 (CB7598) 的前药形式。

GC46471 17β-hydroxy Exemestane-d3 A neuropeptide with diverse biological activities

GC46456 16α-Hydroxyetiocholanolone A metabolite of 16α-DHEA and androstenedione

GC60589 Apalutamide D4

ARN-509-d4

ApalutamideD4(ARN-509D4)是Apalutamide的一种氘代化合物。Apalutamide是有效，竞争性的雄激素受体(AR)拮抗剂，IC50为16nM。

GC39451 Testosterone (propionate)

丙酸睾丸素

An Analytical Reference Standard

GC45935 Testosterone

睾酮

An Analytical Reference Standard

GC45530 Norgestrel-d6

左炔诺孕酮 d6

An internal standard for the quantification of norgestrel

GC37687 Stanolone benzoate

17-安息香酸雄甾醇酮

Stanolone benzoate (Androstanolone benzoate) 是一种合成的雄激素和合成代谢类固醇。

GC36981 PROTAC AR Degrader-4 PROTAC AR Degrader-4 包含 cIAP1 配体结合基团，linker 和雄激素受体 (AR) 配体结合基团。基于 cIAP1 的降解剂也被称为 SNIPER。

GC36820 Ostarine Ostarine (GTx-024, MK-2866, Enobosarm) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM, and is tissue-selective for anabolic organs. Phase 3.

GC36621 MK-0773

PF-05314882

MK-0773 是一种选择性雄激素受体调节剂 (selective androgen receptor modulators)，与 AR 结合，IC50 值为 6.6 nM。

GC36344 Isosilybin B

异水飞蓟宾B

Isosilybin B，一种从 silymarin 中分离的黄酮木脂素，具有抗前列腺癌 (PCA) 活性，抑制癌细胞增殖，诱导 G1 期阻滞和凋亡。Isosilybin B 引起雄激素受体降解。

GC35541 Boldenone Undecylenate

宝丹酮十一烯酸酯

An Analytical Reference Standard

GC35534 BMS-564929 BMS-564929 是一种雄激素受体 (AR) 激动剂，结合到雄激素受体，Ki 为 2.11±0.16 nM。

GC35069 2,2,5,7,8-Pentamethyl-6-Chromanol

3,4-二氢-2,2,5,7,8-五甲基-2H-1-苯并吡喃-6-酚,PMC

2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) 是维生素 E (α-tocopherol) 的抗氧化部分。2,2,5,7,8-Pentamethyl-6-Chromanol 具有有效的雄激素受体 (androgen receptor) 信号调节和抗前列腺癌细胞系的抗癌活性。

GC45239 δ4-Abiraterone

阿比特龙代谢物,Δ4-Abiraterone; CB-7627; Abiraterone D4A metabolite

An active metabolite of abiraterone

GC44861 S-23

(S)-2-(芴甲氧羰基)-3-联苯基氨基丙酸

A selective androgen receptor modulator

GC44686 Prochloraz

咪鲜胺; BTS 40542

An imidazole antifungal

GC44527 p,p'-DDE

2，2-双（4-氯苯基）-1，1-二氯乙烯,4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene

A metabolite and degradation product of the pesticide DDT

GC44405 Nilutamide

尼鲁米特,Nilandron; RU 23908

A non-steroidal androgen receptor antagonist

GC44363 Neoaureothin

NSC 260179, Spectinabilin

A bacterial metabolite

GC41300 17β-hydroxy Exemestane

亚甲基宝丹酮

An active metabolite of exemestane

GC41187 Boldenone Cypionate

宝丹酮环戊丙酸酯

An Analytical Reference Standard

GC41153 Tibolone

替勃龙

A tissue-selective steroid with estrogenic and androgenic effects

GC40528 11α-hydroxy Testosterone A CYP3A metabolite of testosterone

GC34887 Androstanolone acetate

雄诺龙醋酸酯

Androstanoloneacetate是一种雄激素配体，靶向作用于雄激素受体α(AR)。Androstanoloneacetate通过连接桥与cIAP1配体Bestatin结合从而形成PROTAC分子。

GC34005 Dehydroisoandrosterone 3-acetate (Dehydroepiandrosterone 3-acetate)

醋酸去氢表雄酮; Dehydroepiandrosterone 3-acetate; DHEA acetate

Dehydroepiandrosterone 3-acetate 是一种睾酮/雌激素前体和已知的脊椎动物攻击性调节剂。

GC33224 Proxalutamide (GT0918)

GT0918; Pruxelutamide

Proxalutamide (GT0918) is a second-generation androgen receptor antagonist that binds to the ligand-binding domain of AR with an IC50 of 32 nM in the AR competive binding assays.

GC32908 UT-155 UT-155是一种选择性的、有效的雄激素受体(AR)拮抗剂，与AR-LBD结合的Ki值为267nM。

GC32907 N-desmethyl Enzalutamide (N-desmethyl MDV 3100)

4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫代-1-咪唑烷基]-2-氟苯甲酰胺,N-desmethyl MDV 3100

N-desMethyl EnzalutaMide (N-desmethyl MDV 3100) is the active metabolite of Enzalutamide, which is an oral androgen receptor inhibitor for treatment of castration-resistant prostate cancer.

GC32408 LGD-4033 An Analytical Reference Standard

GC32403 LGD-3303 LGD-3303是一种选择性雄激素受体调节剂(SARM)。

GC32402 ORM-15341 ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 value of 38 nM and the inhibition constant (Ki) value of 8?nM.

GC31742 Ailanthone (δ13-Dehydrochaparrinone)

臭椿酮,Δ13-Dehydrochaparrinone

A quassinoid with diverse biological activities

GC31738 ACP-105 ACP-105 is an orally available and potent selective androgen receptor modulator (SARM) with pEC50 of 9.0 and 9.4 for AR wild type and AR mutation T877A, respectively.