Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC45005 TDFA (trifluoroacetate salt)
Thr-Asp-F-amidine
A PAD4 inhibitor
GC44984 TAF 10 Peptide
TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)Associated Factor, TBPAssociated Factor 10, TAFII30
A peptide associated with RNA polymerase II activity
GC44886 S-Farnesyl Thioacetic Acid
FTA
A competitive inhibitor of SAM-dependent methyltransferase
GC44866 SAHA-d5
SAHA-d5; Suberoylanilide hydroxamic acid-d5
An internal standard for the quantification of SAHA
GC44865 SAHA-BPyne
Click Tag SAHA-BPyne, Suberoylanilide Hydroxamic AcidBPyne
A probe for HDAC activity
GC44859 S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)
5'-[[(3S)-3-氨基-3-羧基丙基]甲基锍]-5'-脱氧腺苷氯化物二盐酸盐
Ubiquitous methyl donor
GC44685 Procaine (hydrochloride)
Novocaine
Procaine (hydrochloride) is an analytical reference standard categorized as a local anesthetic that is used as an adulterant.
GC44668 Posaconazole D-Glucuronide
Posaconazole N-β-D-Glucuronide
A metabolite of posaconazole
GC44477 NVS-CECR2-1
NVS-1
A potent and selective CECR2 inhibitor
GC44476 NVP-BSK805 (hydrochloride) A potent, selective JAK2 inhibitor
GC44401 Nicotinamide riboside
烟酰胺核糖
烟酰胺核苷是维生素 B3 和 NAD+ 前体的一种形式，通过烟酰胺核苷激酶 (NRK) 和 NMNAT，或通过核苷磷酸化酶和 NAM 补救作用，转化为生物可利用的 NAD+.在体外实验中，烟酰胺核苷通过激活 SirT1/PGC-1α/线粒体生物合成途径减轻酒精引起的肝损伤。
GC44250 MS351
MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.
GC44184 Methylstat (hydrate) A cell-permeable demethylase inhibitor
GC43889 I-CBP112 (hydrochloride) A p300 and CBP inhibitor
GC43865 Histone H4 Peptide Substrate (15-24)
Histone H4K20 Peptide, SET8 Methyltransferase Acceptor Peptide
Substrate for acceptor peptide SET8
GC43864 Histone H4 Peptide Substrate (1-21)
H4 Peptide
Target substrate for several histone modifying enzymes
GC43863 Histone H3K9Me3 (1-24) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ARTKQTAR-K(Me3)-STGGKAPRKQLATKA, H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Me3)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-OH, H3K9me3, Lys(Me3)9-Histone H3 (1-24), Histone H3 (1-24) (Lys9me3)
A peptide fragment of histone H3
GC43862 Histone H3K9Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ARTKQTAR-K(Me3)-STGGKAPRKQLA, H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Me3)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-OH, Lys(Me3)9-Histone H3 (1-21), Histone H3 (1-21) (Lys9me3), H3K9me3
A peptide fragment of histone H3
GC43861 Histone H3K9Ac (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ARTKQTAR-K(Ac)-STGGKAPRKQLA, Histone H3 (1-21) (Lys9ac), Lys(Ac)9-Histone H3 (1-21)
A peptide fragment of histone H3
GC43860 Histone H3K9Ac (1-20) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ARTKQTAR-K(Ac)-STGGKAPRKQL, Histone H3 (1-20) (Lys9ac), Lys(Ac)9-Histone H3 (1-20)
A peptide fragment of histone H3
GC43859 Histone H3K79Me3 (73-83) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
EIAQDF-K(Me3)-TDLR, H3K79me3, Histone H3 (73-83) (Lys79me3), H-Glu-Ile-Ala-Gln-Asp-Phe-Lys(Me3)-Thr-Asp-Leu-Arg-OH, Lys(Me3)79-Histone H3 (73-83)
A peptide fragment of histone H3
GC43858 Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ART-K(Me3)-QTARKSTGGKAPRKQLA, H3K4(Me3), Histone H3 (1-21) (Lys4me3), Lys(Me3)4-Histone H3 (1-21)

A peptide fragment of histone H3
GC43857 Histone H3K4Me2 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ART-K(Me2)-QTARKSTGGKAPRKQLA, Histone H3 (1-21) (Lys4me2), Lys(Me2)4-Histone H3 (1-21)
A peptide fragment of histone H3
GC43856 Histone H3K4Me2 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ART-K(Me2)-QTARKS, H-Ala-Arg-Thr-Lys(Me2)-Gln-Thr-Ala-Arg-Lys-Ser-OH, Histone H3 (1-10) (Lys4me2), Lys(Me2)4-Histone H3 (1-10)
A peptide fragment of histone H3
GC43855 Histone H3K4Me1 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ART-K(Me1)-QTARKSTGGKAPRKQLA, Histone H3 (1-21) (Lys4me1), Lys(Me1)4-Histone H3 (1-21)
A peptide fragment of histone H3
GC43854 Histone H3K4Me1 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) Histone H3K4Me1 (1-10) is an N-terminal fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence.
GC43853 Histone H3K36Me3 (21-44)-GK-biotin (trifluoroacetate salt)
ATKAARKSAPATGGV-K(Me3)-KPHRYRPG-GK(Biotin), Histone H3 (21-44) (Lys36me3), Lys(Me3)36-Histone H3 (21-44)-GK(Biotin)
A biotinylated peptide fragment of histone H3
GC43852 Histone H3K36Me2 (21-44)-GK-biotin (trifluoroacetate salt)
ATKAARKSAPATGGV-K(Me2)-KPHRYRPG-GK(Biotin), Lys(Me2)36-Histone H3 (21-44)-GK(Biotin), Histone H3 (21-44) (Lys36me2)-biotin
A biotinylated peptide fragment of histone H3
GC43851 Histone H3K27Me3 (23-34) (human, mouse, rat, bovine) (trifluoroacetate salt)
Lys(Me3)27-Histone H3 (23-34), Histone H3 (23-34) (Lys27me3), KAAR-K(Me3)-SAPATGG
A peptide fragment of histone H3
GC43850 Histone H3K27Me3 (21-44)-K-biotin (trifluoroacetate salt)
ATKAAR-K(Me3)-SAPATGGVKKPHRYRPG-K(Biotin), H3(21-44)K27me3 Substrate, Histone H3 (21-44) (Lys27me3), Lys(Me3)27-Histone H3 (21-44)-K(Biotin)
A biotinylated peptide fragment of histone H3
GC43849 Histone H3K27Me3 (21-44)-GK-biotin (trifluoroacetate salt)
ATKAAR-K(Me3)-SAPATGGVKKPHRYRPG-GK(Biotin), H3(21-44)K27me3 Substrate, Histone H3 (21-44) (Lys27me3), Lys(Me3)27-Histone H3 (21-44)-GK(Biotin)
A biotinylated peptide fragment of histone H3
GC43848 Histone H3K27Me2 (23-34) (trifluoroacetate salt)
Lys(Me2)27-Histone H3 (23-34), Histone H3 (23-34) (Lys27me2), KAAR-K(Me2)-SAPATGG
A peptide fragment of histone H3
GC43847 Histone H3K27Me2 (21-44)-GK-biotin (trifluoroacetate salt)
ATKAAR-K(Me2)-SAPATGGVKKPHRYRPG-GK(Biotin), Histone H3 (21-24) (Lys27me2)-GK(Biotin), Lys(Me2)27-Histone H3 (21-44)-GK(Biotin) (trifluoroacetate salt)
A biotinylated peptide fragment of histone H3
GC43846 Histone H3K27Me1 (23-34) (trifluoroacetate salt)
Histone H3 (23-34) (Lys27me1), KAAR-K(Me1)-SAPATGG, Lys(Me1)27-Histone H3 (23-34)
A peptide fragment of histone H3
GC43845 Histone H3K27Me1 (21-44)-GK-biotin (trifluoroacetate salt)
ATKAAR-K(Me1)-SAPATGGVKKPHRYRPG-GK(Biotin), Lys(Me1)27-Histone H3 (21-44)-GK(Biotin), Histone H3 (21-44) (Lys27me1)
A biotinylated peptide fragment of histone H3
GC43844 Histone H3K27Me1 (15-39)-K-biotin (trifluoroacetate salt)
Lys(Me1)27-Histone H3 (15-39)-K(Biotin), Histone H3 (15-39) (Lys27me1), APRKQLATKAAR-K(Me)-SAPATGGVKKPH-K(Biotin)-NH2
A biotinylated peptide fragment of histone H3
GC43843 Histone H3K27Ac (23-34) (human, mouse, rat, bovine) (trifluoroacetate salt)
Histone H3 (23-34) (Lys27ac), KAAR-K(Ac)-SAPATGG, Lys(Ac)27-Histone H3 (23-34)
A peptide fragment of histone H3
GC43842 Histone H3K27Ac (21-44)-GK-biotin amide (trifluoroacetate salt)
ATKAAR-K(Ac)-SAPSTGGVKKPHRYRPGG-K(Biotin)-NH2
A biotinylated peptide fragment of histone H3
GC43841 Histone H3K27Ac (21-43)-GGK-biotin (trifluoroacetate salt)
ATKAAR-K(Ac)-SAPATGGVKKPHRYRPG-GK(Biotin), Lys(Ac)27-Histone H3 (21-43)-GGK(Biotin)
A biotinylated peptide fragment of histone H3
GC43840 Histone H3K14Ac (9-19) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
Histone H3 (9-19) (Lys14ac), H3K14Ac, KSTGG-K(Ac)-APRKQ, Lys(Ac)14-Histone H3 (9-19)
A peptide fragment of histone H3
GC43839 Histone H3K14Ac (1-19) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ARTKQTARKSTGG-K(Ac)-APRKQ, Lys(Ac)14-Histone H3 (1-19), Histone H3 (Lys14ac)
A peptide fragment of histone H3
GC43837 Histone H3 Peptide Substrate (1-21)
H3 Peptide
Target substrate for several histone modifying enzymes
GC43835 Histone H3 (5-23) (yeast) (trifluoroacetate salt)
H3p19, QTARKSTGGKAPRKQLASK
A peptide fragment of histone H3
GC43834 Histone H3 (5-23) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
QTARKSTGGKAPRKQLATK
A peptide fragment of histone H3
GC43833 Histone H3 (23-34) (human, mouse, rat, bovine) (trifluoroacetate salt)
KAARKSAPATGG
A peptide fragment of histone H3
GC43832 Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)
ATKAARKSAPSTGGVKKPHRYRPG-GK(Biotin)-NH2, Histone H3 (21-44)
A biotinylated peptide fragment of histone H3
GC43831 Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
ATKAARKSAPATGGVKKPHRYRPG-GK(Biotin)
A biotinylated peptide fragment of histone H3
GC43830 Histone H3 (21-44) (Phospho-Ser28) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ATKAARK-pS-APSTGGVKKPHRYRPG, pSer28-Histone H3 (21-44)
A peptide fragment of histone H3
GC43829 Histone H3 (1-20) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ARTKQTARKSTGGKAPRKQL
A peptide fragment of histone H3
GC43828 Histone H3 (1-18)-WC amide (trifluoroacetate salt)
ARTKQTARKSTGGKAPRKWC-NH2
A peptide fragment of histone H3