Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC43827 Histone H3 (1-15) (Phospho-Ser10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ARTKQTARK-pS-TGGKA, pSer10-Histone H3 (1-15), 1-15 H3pS10, H3S10ph (1-15), H31-15S10ph
A peptide fragment of histone H3
GC43826 Histone H2A (1-20) (human, mouse, rat, bovine) (trifluoroacetate salt)
H-Ser-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Ala-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser-Arg-OH, SGRGKQGGKARAKAKTRSSR
A peptide fragment of histone H2A
GC43806 HC Toxin
玉米圆斑病菌毒素
Potent HDAC inhibitor
GC43794 GSK-J5 (hydrochloride) A negative control compound for GSK-J4
GC43792 GSK-J2 (sodium salt) A negative control compound for GSK-J1
GC43789 GSK199 (hydrochloride) A PAD4 inhibitor
GC43788 GSK121 (trifluoroacetate salt) A PAD4 inhibitor
GC43787 GSK106 (hydrochloride) An inactive control for GSK484 and GSK199
GC43715 Furamidine (hydrochloride)
呋喃脒二盐酸盐,DB75 dihydrochloride; NSC 305831 dihydrochloride
A selective PRMT1 inhibitor and antiprotozoal agent
GC43651 F-Amidine (trifluoroacetate salt) A PAD inhibitor
GC43406 Delphinidin (chloride)
氯化花翠素
Natural vasorelaxant and inhibitor of EGFRs and HATs
GC43354 Cysmethynil
Icmt Inhibitor
An inhibitor of protein prenylation
GC43321 CPTH6 (hydrobromide) A Gcn5 and pCAF HAT inhibitor
GC43320 CPI-268456 A ligand of BRD4
GC43318 coumarin-SAHA
coumarin-Suberoylanilide Hydroxamic Acid
A fluorescent probe for HDAC
GC43275 Citrulline-specific Probe-Rhodamine
Rhodamine Phenylglyoxal, RhPG
A fluorophore that detects protein citrullination
GC43202 CAY10723
AFM30a, AMF30a
A PAD2 inhibitor
GC43201 CAY10722 A SIRT3 inhibitor
GC43200 CAY10721 An inhibitor of SIRT3
GC43192 CAY10685 A “clickable” analog of CPTH2
GC43147 CAY10398
MD 85, PX 089274
A potent, cost-effective histone deacetylase inhibitor
GC42944 BIX01294 (hydrochloride hydrate) An inhibitor of G9a histone methyltransferase
GC42933 Binucleine 2 An inhibitor of Drosophila Aurora B kinase
GC42910 BB-F-Yne A clickable PAD inhibitor
GC42790 Amodiaquine
阿莫地喹,Amodiaquin
A prodrug form of N-desethyl amodiaquine
GC42785 Amifostine (hydrate)
氨磷汀三水合物,WR2721 trihydrate
A broad-spectrum radioprotective thiol
GC42784 AMI-1 (sodium salt)
Arginine N-Methyltransferase Inhibitor-1
A cell permeable inhibitor of PRMTs
GC42562 5-Methyl-2'-deoxycytidine
5-甲基-2'-脱氧胞苷,5-Methyldeoxycytidine
A pyrimidine nucleoside
GC42466 4-pentynoyl-Coenzyme A (trifluoroacetate salt)
Click Tag 4pentynoylCoA
A protein acetylation probe
GC42075 2,4-Pyridinedicarboxylic Acid (hydrate)
2,4-吡啶二羧酸
An inhibitor of 2-oxoglutarate-dependent enzymes
GC41984 1-Alaninechlamydocin An HDAC inhibitor
GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
Tetrahydrofolate, THFA
A folic acid derivative
GC41638 TSI-01 TSI-01是溶血磷脂酰胆碱酰基转移酶2（LPCAT2）的选择性抑制剂，对人 LPCAT2和LPCAT1的IC₅₀值分别为0.47和3.02µM。
GC41625 Oroxylin A
千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein
A flavonoid with diverse biological activities
GC41601 CAY10591
SIRT1 Activator 3, Sirtuin 1 Activator 3
A SIRT1 activator
GC41572 PRLX-93936 An erastin analog with antitumor activity
GC41495 HDAC3 Inhibitor
Histone Deacetylase 3
An allosteric HDAC3 inhibitor
GC41263 TP-064 A potent inhibitor of PRMT4
GC41088 (6S)-Tetrahydrofolic Acid An active diastereomer
GC41085 HDAC6 Inhibitor
Histone Deacetylase 6
An inhibitor of HDAC6
GC40923 BRD4884 A kinetically selective HDAC2 inhibitor
GC40918 Gramicidin A
甲胎蛋白
A channel-forming ionophore
GC40900 Ganoderic Acid D
灵芝酸 D
An oxygenated triterpenoid
GC40791 MS-1020 A cell-permeable inhibitor of JAK3
GC40767 CAY10669 An inhibitor of PCAF
GC40674 APHA Compound 8
组蛋白去乙酰化酶
A class I and II HDAC inhibitor
GC40667 Aurora Kinase Inhibitor II
4-(4-Benzamidoanilino)-6,7-dimethoxyquinazoline
Blocks Aurora A kinase activity
GC40628 TP-472 A BRD9 inhibitor
GC40555 Tiopronin
BRN 1859822, (±)-Tiopronin
Tiopronin is an antioxidant that has diverse biological activities.
GC40496 N6-Methyladenine
6-(甲氨基)嘌呤
A modified purine of microbial genomes