Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC19405 PF-06700841 P-Tosylate
PF-06700841 P-Tosylate
An inhibitor of JAK1 and TYK2
GC19398 PIM447
LGH447
PIM447 (LGH447) 是一种有效的、口服的、选择性的泛 PIM 激酶抑制剂，对 PIM1、PIM2 和 PIM3 的 Ki 值分别为 6、18 和 9 pM。 PIM447 具有双重抗骨髓瘤和骨保护作用。 PIM447 诱导细胞凋亡。
GC19388 XY1
N-2-萘基-N'-[2-氧代-2-(1-吡咯烷基)乙基]脲
A negative control for SGC707
GC19368 Upadacitinib
乌帕替尼; ABT-494
A JAK1 inhibitor
GC19361 TP-3654 A Pim kinase inhibitor
GC19360 TMP195
TMP195游离态

TMP195 是一种有效的选择性 IIa 类 HDAC 抑制剂，对 HDAC4、HDAC5、HDAC7 和 HDAC9 的 IC50 分别为 59 nM、60 nM、26 nM 和 15 nM。
GC19337 SR-4370 An HDAC3 inhibitor
GC19334 Solcitinib
索西替尼; GSK-2586184; GLPG-0778
A JAK1 inhibitor
GC19329 SGC2085 A PRMT4/CARM1 inhibitor
GC19328 SF2523 A dual inhibitor of PI3K and BRD4
GC19320 SAR-20347 A JAK family kinase inhibitor
GC19298 PLX51107 A BET family protein inhibitor
GC19288 PF-06651600
PF-06651600
PF-06651600 (PF-06651600) 是一种具有口服活性的选择性 JAK3 抑制剂，IC50 为 33.1 nM。
GC19264 NMS-P118
2-[1-(4,4-二氟环己基)-4-哌啶基]-6-氟-2,3-二氢-3-氧代-1H-异吲哚-4-甲酰胺
A potent and selective PARP1 inhibitor
GC19251 MK-8617 A HIF-PH1, -2, and -3 inhibitor
GC19248 Mivebresib
米维布塞; ABBV-075
A BRD2, BRD4, and BRDT inhibitor
GC19247 MI-503 MI-503 是一种高效且具有口服生物利用度的 menin-mLL 相互作用的小分子抑制剂。
GC19246 MI-463 An inhibitor of menin-MLL fusion protein interactions
GC19211 JQEZ5 An EZH2 inhibitor
GC19210 JQ-1 carboxylic acid
(6S)-4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]噻唑并[4,3-A][1,4]二氮杂卓-6-乙酸
A selective inhibitor of BET bromodomains
GC19204 Itacitinib
伊他替尼,INCB039110
A JAK1 inhibitor
GC19200 INCB-057643 A BET family protein inhibitor
GC19190 HDAC-IN-4
CXD101
An HDAC inhibitor
GC19189 HDAC8-IN-1
MDK-7933
An HDAC8 inhibitor
GC19184 GSK484 hydrochloride GSK484是一种选择性PAD4抑制剂，已被用作抗缺血化合物，对PAD4具有抑制活性。
GC19181 GSK2807 Trifluoroacetate GSK2807 Trifluoroacetate 是一种有效的、选择性的、SAM 竞争性的 SMYD3 抑制剂，Ki 为 14 nM，IC50 为 130 nM。
GC19149 EZM 2302
GSK3359088
A PRMT4 inhibitor
GC19141 EPZ011989 An orally bioavailable EZH2 inhibitor
GC19130 EED226 A potent and allosteric inhibitor of PRC2
GC19129 EDO-S101
Tinostamustine
An HDAC inhibitor and DNA alkylating agent
GC19119 dBET1
2-((S)-4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂卓-6-基)-N-(4-(2-((2-(2,6-二氧代哌啶-3-基)-1,3-二氧代异吲哚啉-4-基)氧基)乙酰氨基)丁基)乙酰胺
A hybrid molecule containing (+)-JQ-1 and thalidomide
GC19098 CeMMEC1 A selective TAF1 bromodomain 2 inhibitor
GC19092 CCT241736 A dual inhibitor of Aurora kinases and FLT3
GC19038 ARV-825 A BRD4 inhibitor that drives BRD4 degradation
GC19020 ACY-738
N-羟基-2-[(1-苯基环丙基)氨基]-5-嘧啶甲酰胺
An HDAC6 inhibitor
GC19013 3-TYP
吡啶-3-乙炔
3-TYP 抑制 SIRT3，IC50 为 16 nM，比 SIRT1 和 SIRT2 更有效，IC50 分别为 88 nM 和 92 nM。
GC18949 CAY10677
Icmt Inhibitor 15
An inhibitor of protein prenylation
GC18925 Cl-Amidine (hydrochloride)
N-[(1S)-1-(氨基羰基)-4-[(2-氯-1-亚氨基乙基氨基]丁基]-苯甲酰胺盐酸盐
A PAD inhibitor
GC18915 Trapoxin A Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor.
GC18731 LP99 A selective inhibitor of BRD7/9
GC18729 MZ1 A PROTAC that drives BRD4 degradation
GC18650 S-(5'-Adenosyl)-L-methionine (tosylate)
S-腺苷蛋氨酸对甲苯磺酸盐,S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate
A methyl donor and cofactor
GC18642 SW155246 A DNA methyltransferase 1 inhibitor
GC18623 α-Hydroxyglutaric Acid
2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid
An α-hydroxy acid
GC18577 CID-2818500
Α-硝基茋
An inhibitor of PRMT1
GC18509 3-Methylcytidine (methosulfate)
3-甲基胞苷甲基硫酸酯
An internal standard for HPLC
GC18508 BAY-299 A potent and selective BRD1 inhibitor
GC18428 SGC2085 (hydrochloride) A PRMT4/CARM1 inhibitor
GC18408 BML-278
DIETHYL1-BENZYL-4-PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE锛圵S201542锛,WUXIAPPTEC"
An activator of SIRT1, SIRT2, and SIRT3
GC18402 GSK3117391 An HDAC inhibitor