Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC18236 Echinomycin
醌霉素A,Antibiotic A 654I； NSC 13502； NSC 526417； Quinomycin A； SK 302B
An inhibitor of HIF-1-mediated gene transcription
GC18228 CAY10602
1-(4-氟苯基)-3-(苯磺酰基)-1H-吡咯并[2,3-B]喹喔啉-2-胺
A SIRT1 activator
GC18206 WT161 A potent inhibitor of HDAC6
GC18172 E7449
E7449; 2X-121
An inhibitor of PARP1, PARP2, and TNKS1/2
GC18161 BCI-121 An inhibitor of SMYD3
GC18159 BAY-598 An inhibitor of SMYD2
GC18153 WM-8014
WM8014,WM 8014
An inhibitor of KAT6A and KAT6B
GC12530 PFI-2 (hydrochloride)
(R)-PFI-2 hydrochloride
GC11302 Hinokitiol
桧木醇; β-Thujaplicin
A tropolone with diverse biological activities
GC15711 Aurora Kinase Inhibitor III A potent inhibitor of Aurora A kinase
GC11792 OG-L002 HCl An LSD1 inhibitor
GC16811 Vadadustat
伐度司他,PG-1016548; AKB-6548
An inhibitor of HIF-PH2 and HIF-PH3
GC17724 Thiomyristoyl
TM
A potent and selective SIRT2 inhibitor
GC12367 CM-272 An inhibitor of G9a, GLP, and DNA methyltransferases
GC14524 CTPB A selective activator of p300 HAT
GC15931 AGK7
SIRT2 Inhibitor (Inactive Control)
An inactive control for AGK2
GC13088 BRD6688 A kinetically selective HDAC2 inhibitor
GC14686 JFD00244
BML-266
An inhibitor of SIRT2
GC16114 Bizine An LSD1 inhibitor
GC11716 SIRT1/2 Inhibitor IV
Cambinol,NSC 112546,SIRT1 Inhibitor II,SIRT2 Inhibitor VI
Cell-permeable inhibitor of SIRT1 and SIRT2
GC12630 MS37452 An inhibitor of CBX7 chromodomain binding to H3K27me3
GC12009 HAT Inhibitor II
组蛋白乙酰转移酶抑制剂II,Histone Acetyltransferase Inhibitor II
An inhibitor of HAT p300
GC13634 (S)-PFI-2 (hydrochloride)
(+)-PFI-2
Negative control of (R)-PFI 2
GC14016 Sulforaphane
萝卜硫素

萝卜硫素 (SFN) 称为 [1-isothiocyanato-4-(methylsulfinyl)butane]。
GC15379 JNJ-42041935
HIF-PHD Inhibitor II
A selective inhibitor of HIF-PH enzymes
GC15974 bpV(HOpic) (potassium salt, technical grade)
Bisperoxovanadium(HOpic)
A PTEN inhibitor
GC12255 IOX4 A selective, bioavailable inhibitor of HIF-PH2
GC15969 PTP Inhibitor IV
Protein Tyrosine Phosphatase Inhibitor IV
An active-site directed inhibitor of protein tyrosine phosphatases
GC10408 2-D08 An inhibitor of sumoylation
GC18012 GSK-LSD1 (hydrochloride) An LSD1 inhibitor
GC11806 β-Glycerophosphate (sodium salt hydrate)
五水β-甘油磷酸钠(二钠五水合物)

An inhibitor of alkaline phosphatase
GC12775 2',3',5'-triacetyl-5-Azacytidine
三乙酰基-阿扎胞苷
A prodrug form of 5-azacytidine
GC16743 RN-1 (hydrochloride)
LSD1 Inhibitor IV
An irreversible LSD1 inhibitor
GC14168 UMB-32 An inhibitor of BRD4, TAF1, and TAF1L bromodomains
GC17005 4-iodo-SAHA
ISAHA
A potent SAHA analog
GC16763 NI-57 A BRPF bromodomain inhibitor
GC14240 MS049 (hydrochloride) A selective, dual PRMT4/PRMT6 inhibitor
GC13025 GSK6853 A selective chemical probe for the bromodomain of BRPF1
GC16900 PRL-3 Inhibitor
BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor
An inhibitor of PTP4A3
GC13668 Phthalazinone pyrazole Potent, selective inhibitor of Aurora kinase A
GC12458 N-Oxalylglycine
N-草酰甘氨酸,NOG
An inhibitor of JMJD2 histone demethylases
GC12082 Cantharidic Acid (sodium salt) A protein phosphatase inhibitor
GC13062 JGB1741
ILS-JGB-1741
A SIRT1 inhibitor
GC13534 Lysine-specific Demethylase Inhibitor (1C)
KDM1 Inhibitor I|LSD1 Inhibitor
lysine-specific demethylase Inhibitor
GC15120 PTP Inhibitor I
2-溴-4'-羟基苯乙酮,α-Bromo-4-hydroxyacetophenone|2-Bromo-4'-hydroxyacetophenone|4-Hydroxyphenacyl bromide|Protein Tyrosine Phosphatase Inhibitor I|SHP-1 Inhibitor II
A SHP-1(ΔSH2) and PTP1B inhibitor
GC15301 PBIT
2-p-tolyl-1,2-Benzisothiazolin-3-one
An inhibitor of JARID1 family demethylases
GC17922 4'-bromo-Resveratrol
5-[(E)-2-(4-溴苯基)乙烯基]间苯二酚,4′‐BR
A potent inhibitor of SIRT1 and SIRT3
GC15804 PTP Inhibitor II
alpha-溴-4-甲氧基苯乙酮,α-Bromo-4’-methoxyacetophenone|ω-Bromo-4’-methoxyacetophenone|4-(Bromoacetyl)anisole|4-Methoxyphenacyl bromide|NSC 129010|Protein Tyrosine Phosphatase Inhibitor II
A SHP-1(ΔSH2) inhibitor
GC16432 MS023 (hydrochloride) An inhibitor of type I PRMTs
GC13014 AZD 5153 A BRD4 inhibitor