Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC14362 Lin28 1632 An inhibitor of the Lin28/let-7 interaction
GC10898 5-(N,N-dimethyl)-Amiloride (hydrochloride)
DMA,L-591,605,MK-685
An inhibitor of Na⁺/H⁺ exchangers
GC10226 Butyrolactone 3
丁内酯 3; MB-3
A HAT inhibitor
GC14428 CPTH2 (hydrochloride) A HAT inhibitor
GC14282 3-acetyl-11-keto-β-Boswellic Acid
11-羰基-Β-乙酰乳香酸,3-O-acetyl-11-keto-β-Boswellic acid,AKBA
A selective 5-LO inhibitor
GC16298 CPI-1205 EZH2抑制剂
GC14597 ITSA-1 (ITSA1)
ITSA-1 是一种组蛋白去乙酰化酶（HDAC）激活剂，能够抑制HDAC抑制剂TSA对HDAC的抑制，但不抑制其他HDAC抑制剂。
GC14103 NSC228155 An EGFR activator and inhibitor of KID-KIX interactions
GC10774 CPI-455
6-异丙基-7-氧代-5-苯基-4,7-二氢吡唑并[1,5-A]嘧啶-3-腈
A KDM5 inhibitor
GC17023 HLCL-61 A PRMT5 inhibitor
GC10382 CPI-637 An inhibitor of CBP/EP300 bromodomains
GC15152 PF-CBP1 An inhibitor of the CBP and p300 bromodomains
GC16726 BI-7273 A potent BRD9 bromodomain inhibitor
GC16817 BI-9564 A selective BRD9/7 bromodomain inhibitor
GC10099 MS023
N1-甲基-N1-[[4-[4-(异丙氧基)苯基]-1H-吡咯-3-基]甲基]-1,2-乙二胺
MS023 是 I 型蛋白精氨酸甲基转移酶 (PRMT) 的有效、选择性和细胞活性抑制剂。
GC14585 GSK591
EPZ015866; GSK3203591
A chemical probe for PRMT5
GC12588 I-BRD9 A BRD9 bromodomain inhibitor
GC16397 OICR-9429 A probe for WDR5
GC16725 AZ6102
REL-2-[4-[6-[(3R,5S)-3,5-二甲基-1-哌嗪基]-4-甲基-3-吡啶基]苯基]-3,7-二氢-7-甲基-4H-吡咯并[2,3-D]嘧啶-4-酮
A TNKS1/2 inhibitor
GC10905 Amodiaquine dihydrochloride dihydrate
阿莫地喹盐酸盐; Amodiaquin dihydrochloride dihydrate
A prodrug form of N-desethyl amodiaquine
GC16509 Adox
腺苷二醛
An irreversible inhibitor of SAH hydrolase
GC16261 LLY507 A SMYD2 inhibitor
GC16647 Daprodustat(GSK1278863)
达普司他,GSK1278863
A HIF-PH1, -2, and -3 inhibitor
GC15102 EPZ020411 A PRMT6 inhibitor
GC14380 BGP-15
(Z)-N-(2-羟基-3-(哌啶-1-基)丙氧基)烟酰胺双盐酸盐
A PARP inhibitor and insulin sensitizer
GC17546 AMI5
水溶伊红,Acid Red 87
曙红 Y（二钠）是一种可溶性酸性红色染料分子。
GC17820 AS8351
NSC51355
A histone demethylase inhibitor
GC16224 EPZ031686 EPZ031686 是一种有效且具有口服活性的 SMYD3 抑制剂，IC50 值为 3 nM。 EPZ031686 可用于癌症研究。
GC17472 Oxamflatin
Metacept-3
Inhibitor of histone deacetylases
GC12288 GSK-J1 sodium salt A dual inhibitor of JMJD3 and UTX
GC12874 SGC707 A potent allosteric inhibitor of PRMT3
GC17555 NVP-TNKS656
TNKS656
A TNKS2 inhibitor
GC17207 UNC3866 An inhibitor of CBX7
GC13942 SirReal2
乙酰胺,2-[(4,6-二甲基-2-嘧啶基)硫]-N-[5-(1-萘甲基)-2-噻唑]-
A selective SIRT2 inhibitor
GC17828 BI-847325 A selective dual MEK/Aurora kinase inhibitor
GC10341 Peficitinb (ASP015K, JNJ-54781532)
培菲替尼,ASP015K; JNJ-54781532
A JAK inhibitor
GC11031 PX-478 2HCl PX-478是一种选择性抑制剂，可以抑制常规和低氧诱导的HIF-1α水平。
GC16875 FLLL32
(2E,2'E)-1,1'-环己基亚基二[3-(3,4-二甲氧基苯基)-2-丙烯-1-酮]
An inhibitor of JAK2/STAT3 signaling
GC15789 GSK2801 A probe for BAZ2A/B bromodomains
GC16914 MN 64 A TNKS inhibitor
GC11652 CHZ868 CHZ868 是一种 II 型 JAK2 抑制剂，在 EPOR JAK2 WT Ba/F3 细胞中的 IC50 为 0.17 μM。
GC12976 Suberohydroxamic Acid
软木肟酸,Suberohydroxamic acid; SBHA
HDAC inhibitor
GC11873 2,4-Pyridinedicarboxylic Acid
2,4-吡啶二羧酸
An inhibitor of 2-oxoglutarate-dependent enzymes
GC17704 Triacetyl Resveratrol
三乙酰基白藜芦醇
A resveratrol derivative with diverse biological activities
GC10979 PFI 4 A chemical probe for BRPF1
GC13442 Sanguinarine chloride
氯化血根碱; Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride
A natural alkaloid with anti-inflammatory and anti-oxidant properties
GC11249 2-hexyl-4-Pentynoic Acid
2-正己基-4-戊炔酸,(±)-2-Hexyl-4-pentynoic acid
An HDAC inhibitor
GC12822 BML-210(CAY10433)
NphenylN'(2Aminophenyl)hexamethylenediamide, CAY10433
A potent, synthetic HDAC inhibitor
GC14367 UF 010 A class I HDAC inhibitor
GC14938 PF-03394197(Oclacitinib)
奥拉替尼
A JAK family kinase inhibitor