Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC10148 RN 1 dihydrochloride
LSD1 Inhibitor IV
An irreversible LSD1 inhibitor
GC17118 GSK J5
N-[2-(3-吡啶基)-6-(1,2,4,5-四氢-3H-3-苯并氮杂卓-3-基)-4-嘧啶基]-BETA-丙氨酸乙酯
A negative control compound for GSK-J4
GC13086 GSK J2
N-[2-(3-吡啶基)-6-(1,2,4,5-四氢-3H-3-苯并氮杂卓-3-基)-4-嘧啶基]-BETA-丙氨酸
A negative control compound for GSK-J1
GC13187 I-BET 151 hydrochloride A BRD2, BRD3, and BRD4 inhibitor
GC17754 IOX 1
5-羰基-8-羟基喹啉
A 2-oxoglutarate oxygenase inhibitor
GC14249 UNC 0642
2-(4,4-二氟-1-哌啶基)-6-甲氧基-N-[1-异丙基-4-哌啶基]-7-[3-(1-吡咯烷基)丙氧基]-4-喹唑啉胺
A G9a histone methyltransferase inhibitor
GC15731 L002
p300/CBP Inhibitor VI, NSC 764414
A p300 acetyltransferase inhibitor
GC15104 (R)-(+)-Etomoxir sodium salt
(R)-(+)-乙莫克舍钠盐,(R)-(+)-Etomoxir sodium salt
(R)-(+)-Etomoxir sodium salt(Etomoxir; ETO)是一种用于代谢和心血管疾病的小分子,经酶转化为活性抑制剂乙托莫西里尔辅酶a (IC50 约为0.01-0.70 µM)后,对CPT-1a和CPT-1b的抑制表现出纳摩尔效价。
GC14817 Salermide A sirtuin inhibitor
GC17881 AGK 2
2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺
AGK2是一种选择性的SIRT2 抑制剂,IC50为3.5 µM。
GC12934 YM 750 YM 750 是一种有效的 acyl-CoA:cholesterol acyltransferase (ACAT) 抑制剂 (IC50\u003d0.18 μM)。
GC10931 VULM 1457 VULM 1457 是一种有效的胆固醇酰基转移酶 (acyl-CoA) 抑制剂。
GC11539 CI 976
CI 976
An inhibitor of ACAT-1
GC11561 NSC 95397
Cdc25 Inhibitor IV, PTP Inhibitor XXIX
An irreversible inhibitor of Cdc25 isoforms
GC16130 C 21 Protein arginine methyltransferase 1 (PRMT1) inhibitor
GC17672 TC-E 5003
N,N'-[磺酰基二(4,1-亚苯基)]二(2-氯乙酰胺)
A PRMT1 inhibitor
GC14361 PFI 3
(2E)-1-(2-羟基苯基)-3-[(1R,4R)-5-(2-吡啶基)-2,5-二氮杂双环[2.2.1]庚-2-基]-2-丙烯-1-酮
Probe for bromodomains of SMARCA2/4 and PB1(bromodomain 5)
GC11340 (R)-PFI 2 hydrochloride
(R)-PFI-2 hydrochloride
A SET7/9 inhibitor
GC13919 Tranylcypromine hydrochloride
反苯环丙胺盐酸盐,SKF 385 hydrochloride
An irreversible, mechanism-based inhibitor of LSD1
GC11381 Tautomycetin
Tautomycetin 是一种有效的特异性 PP1 抑制剂，具有潜在的细胞凋亡诱导活性。
GC12359 Hispidulin
高车前素; Dinatin
A flavonoid with diverse biological activities
GC14875 NSC 663284
DA-3003-1
Inhibitor of Cdc25 isoforms
GC10676 AK-7
N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺
An inhibitor of SIRT2
GC16599 CPI-169 A selective EZH2 inhibitor
GC13926 BMS-345541(free base) BMS-345541(free base) 是 IKK 催化亚基的选择性抑制剂 (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM)。 BMS-345541（游离碱）结合在 IKK 的变构位点。
GC12667 4SC-202
4SC-202(盐的形式),4SC-202
An HDAC1-3 and KDM1A inhibitor
GC13764 Nexturastat A A potent, cell-permeable HDAC6 inhibitor
GC12917 Acetaminophen
对乙酰氨基酚; Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide

An analgesic and antipyretic compound
GC10243 Nanaomycin C
七尾霉素C

Amide of nanaomycin A
GC14066 Procaine
普鲁卡因
An Analytical Reference Standard
GC17052 MK-4827 Racemate selective inhibitor of PARP1/PARP2
GC11767 Hydralazine HCl
盐酸肼屈嗪
An antihypertensive agent
GC15857 Sodium butyrate
丁酸钠
A short-chain fatty acid and HDAC inhibitor
GC11576 Tranylcypromine (2-PCPA) HCl
(1S,2R)-2-苯基-环丙胺盐酸盐,(1S,2R)-SKF 385 hydrochloride
(1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride 是一种有效的抗抑郁剂。
GC17314 OG-L002 An LSD1 inhibitor
GC15259 EPZ004777 HCl EPZ004777 HCl 是一种有效的选择性 DOT1L 抑制剂，IC50 为 0.4 nM。
GC12733 C646 C646是一种有效的选择性p300/CBP组蛋白乙酰转移酶抑制剂(Ki 400 nM),已被证明具有多效性,包括神经保护、抗癌和抗上皮间质转化(anti-EMT)作用。
GC15410 Bufexamac
丁苯羟酸; Bufexamic acid
An NSAID and a class IIb HDAC inhibitor
GC16290 Nafamostat hydrochloride
盐酸萘莫司他
Nafamostat hydrochloride 是一种合成丝氨酸蛋白酶抑制剂，是一种抗凝剂。
GC17676 Nafamostat
萘莫司他
A serine protease inhibitor
GC14490 Donepezil HCl
盐酸多奈哌齐; E2020
An AChE inhibitor
GC12579 GLPG0634
非戈替尼,GLPG0634
A JAK1 inhibitor
GC10154 ABC294640
3-(4-氯苯基)-N-(4-吡啶基甲基)金刚烷-1-甲酰胺,ABC294640
An inhibitor of SPHK2
GC14699 CPI-203 A bioavailable inhibitor of BET bromodomains
GC12698 BAY 87-2243 A mitochondrial complex I inhibitor and inducer of ferroptosis
GC14756 EI1
6-氰基-N-[(1,2-二氢-4,6-二甲基-2-氧代-3-吡啶基)甲基]-1-(1-乙基丙基)-1H-吲哚-4-甲酰胺,KB-145943
A selective inhibitor of EZH2
GC14151 CBB1007 CBB1007 是一种细胞可渗透的脒基胍化合物，可作为一种有效的、可逆的和底物竞争性 LSD1 选择性抑制剂（hLSD1 的 IC50 = 5.27 μM）。
GC13103 AZ505 ditrifluoroacetate
N-环己基-3-[[2-(3,4-二氯苯基)乙基]氨基]-N-[2-[[2-(3,4-二氢-5-羟基-3-氧代-2H-1,4-苯并恶嗪-8-基)乙基]氨基]乙基]丙酰胺二(2,2,2-三氟乙酸盐)
An inhibitor of SMYD2
GC13744 AZ505
N-环己基-3-(3,4-二氯苯乙基氨基)-N-[2-[[2-[5-羟基-3-氧代-3,4-二氢-2H-苯并[B][1,4]恶嗪-8-基]乙基]氨基]乙基]丙酰胺
An inhibitor of SMYD2
GC14063 GSK1324726A
I-BET726
A selective inhibitor of BET family proteins