Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC14321 Sal 003
(2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺
An inhibitor of eIF2α dephosphorylation
GC16958 Okadaic acid
冈田酸
A potent inhibitor of protein phosphatases
GC17966 NFAT Inhibitor
VIVIT peptide
A peptide inhibitor of NFAT
GC16117 INCA-6
Triptycene-1,4-quinone
A cell-permeant inhibitor of NFAT signaling
GC12604 Fumonisin B1
伏马菌素B1

A mycotoxin
GC14395 Fostriecin sodium salt
福司曲星
A potent inhibitor of protein phosphatases 2A and 4
GC14024 DL-AP3
DL-2-氨基-3-磷丙酸
A metabotropic glutamate receptor antagonist
GC17011 C2 Ceramide
N-乙酰基神经鞘氨醇,C2 Ceramide (d18:1/2:0)， C2 Ceramide ，Ceramide (d18:1/2:0)， Cer(18:1/2:0)，N-acetoyl-D-erythro-sphingosine
A cell-permeable analog of naturally occurring ceramides
GC18106 Calyculin A
蛋白磷酸酯酶抑制剂,(-)-Calyculin A
Potent inhibitor of PP1 and PP2A
GC12743 Calcineurin Autoinhibitory Peptide Calcineurin autoinhibitory peptide 是 Ca2+/calmodulin-dependent protein phosphatase (calcineurin) 的选择性抑制剂，IC50 为 ~10 μM。
GC11674 WIKI4
Tankyrase 1/2 Inhibitor V
A potent TNKS1/2 inhibitor
GC17775 NU 1025
NSC 696807
An inhibitor of PARP
GC12869 JW 55
Tankyrase 1/2 Inhibitor IV
A TNKS1/2 inhibitor
GC12991 EB 47 A PARP1 and TNKS2 inhibitor
GC12680 DR 2313
3,5,7,8-四氢-2-甲基-4H-硫代吡喃并[4,3-D]嘧啶-4-酮
A PARP inhibitor
GC14434 BYK 49187 Potent PARP-1/PARP-2 inhibitor
GC10690 BYK 204165
PARP Inhibitor XIV
A selective inhibitor of PARP1
GC16474 4-HQN
4-羟基喹唑啉
A heterocyclic building block
GC17178 TCS PIM-1 1
SC 204330
A Pim-1 kinase inhibitor
GC13488 R8-T198wt R8-T198wt 是一种细胞可渗透的羧基末端 p27Kip1 肽，通过抑制 Pim-1 激酶表现出抗肿瘤活性。
GC13558 PIM-1 Inhibitor 2
PIMi II
A potent PIM-1 kinase inhibitor
GC12419 UNC 926 hydrochloride An antagonist of L3MBTL1, L3MBTL3, and L3MBTL4
GC15125 ZM 449829
2-萘乙烯基酮
An inhibitor of JAK3
GC16584 TCS 21311
NIBR3049
A JAK3 inhibitor
GC12118 SD 1008
SD 1008 是一种有效的 JAK 抑制剂。 SD 1008 抑制 STAT3、JAK2 和 Src 的酪氨酰磷酸化。 SD 1008 还降低 STAT3 依赖性荧光素酶活性。 SD 1008 通过直接阻断 JAK-STAT3 信号通路增强紫杉醇诱导的卵巢癌细胞凋亡。
GC17033 Lestaurtinib
来他替尼; CEP-701; KT-5555
A potent JAK2 and PRK1 kinase inhibitor
GC13347 Cucurbitacin I
葫芦素I,Elatericin B; JSI-124; NSC-521777
An inhibitor STAT3/JAK signaling
GC15391 Cercosporamide
尾孢素酰胺,(-)-Cercosporamide

A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms
GC17055 1,2,3,4,5,6-Hexabromocyclohexane
1,2,3,4,5,6-六溴化环己烷
1,2,3,4,5,6-六溴环己烷（1,2,3,4,5,6-Hexabromocyclohexane）直接抑制JAK2激酶结构域内的口袋，抑制自身磷酸化。
GC15594 PX 12
2-(仲丁基二硫基)-1H-咪唑,IV-2
An irreversible inhibitor of thioredoxin-1
GC14319 ML 228
CID-46742353
A HIF pathway activator
GC13141 KC7F2 An inhibitor of HIF-1a protein synthesis
GC17405 Chetomin
毛壳菌素,NSC 289491
An inhibitor of HIF signaling
GC16518 UNC 0646
N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺
An inhibitor of G9a/GLP methyltransferases
GC14936 Chaetocin
毛壳素
据报道毛壳素是组蛋白甲基转移酶 (HMT)（例如 SUV39H1）的非特异性抑制剂，从而影响基因表达。
GC16386 Tubacin
HDAC6抑制剂
Tubacin (tubulin acetylation inducer)是一种选择性抑制组蛋白去乙酰化酶6 (HDAC6)，诱导α-微管蛋白乙酰化的小分子，IC50为0.004µM。
GC13591 TC-H 106
RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII
A tight-binding inhibitor of class I HDACs
GC11095 Pyroxamide
N-羟基-N'-3-吡啶基辛二酰胺
A HDAC inhibitor
GC15040 NSC 3852
8-羟基-5-硝基喹啉
A tumor cell differentiating agent
GC15536 NCH 51
NCH-51
An HDAC inhibitor
GC13435 KD 5170 An inhibitor of class I and II HDACs
GC17284 Anacardic acid
漆树酸; Hydroginkgolic acid; Ginkgolic Acid C15

A histone acetyltransferase inhibitor
GC12660 AZD1208
AZD 1208;AZD-1208
AZD1208 是一种有效、高选择性且可口服的 Pim 激酶抑制剂，对 PIM1、PIM2 和 PIM3 的 IC50 值分别为 0.4、5 和 1.9nM。
GC17783 Veliparib dihydrochloride
维利帕尼二盐酸盐; ABT-888 dihydrochloride
An orally bioavailable inhibitor of PARP1 and PARP2
GC13102 XL228
N4-(5-环丙基-1H-吡唑-3-基)-N2-[[3-异丙基-5-异恶唑基]甲基]-6-(4-甲基-1-哌嗪基)-2,4-嘧啶二胺,XL-228;XL 228
A tyrosine kinase inhibitor
GC14327 XL019
XL-019;XL 019
A potent, bioavailable JAK2 inhibitor
GC15956 WHI-P97
4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉,WHI-P-97;WHI P97
WHI-P97 是一种有效的选择性 JAK-3 抑制剂。
GC16794 UNC1215
UNC 1215;UNC-1215
Potent L3MBTL3 domain inhibitor
GC14340 Tasquinimod
他喹莫德; ABR-215050
An orally-active anti-cancer compound
GC15109 SRT2104 (GSK2245840)
玻玛西林
SRT2104 (GSK2245840) 是 Sirtuin 1 (SIRT1) 的高选择性小分子激活剂，可穿透血脑屏障，减轻脑萎缩，改善运动功能，并防止糖尿病引起的主动脉内皮功能障碍 .用 SRT2104（3µ；M，48 小时）处理可降低 HG 处理的内皮细胞 (EC) 中的 P53 和 Ac-P53 蛋白水平，但不会降低 P53 mRNA 。