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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. 产品名称 Information
  2. GC17020 S-Ruxolitinib (INCB018424)

    S-鲁索替尼,S-Ruxolitinib; INCB18424

     鲁索替尼 S 对映体是鲁索替尼的 S 对映体。鲁索替尼 S 对映异构体是一种 JAK 抑制剂
  3. GC13848 LY2784544

    Gandotinib

     Potent inhibitor of JAK2
  4. GC12083 CEP-33779

    N-[3-(4-甲基-1-哌嗪基)苯基]-8-[4-(甲磺酰基)苯基]-[1,2,4]三唑并[1,5-A]吡啶-2-胺,CEP 33779,CEP33779

     A potent, orally available inhibitor of JAK2
  5. GC10035 TG101209

    N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺,TG-101209

     An inhibitor of JAK2, FLT3, RET, and JAK3
  6. GC13433 AZ 960

    5-氟-2-[[(1S)-1-(4-氟苯基)乙基]氨基]-6-[(5-甲基-1H-吡唑-3-基)氨基]-3-吡啶腈,AZ-960,AZ960

     A JAK2 inhibitor
  7. GC17050 CYT387

    莫洛替尼,Cyt-387,MOMELOTINIB,CYT 387,CYT 11387

     A potent inhibitor of JAK1 and JAK2
  8. GC14844 Baricitinib (LY3009104, INCB028050)

    巴瑞替尼; LY3009104; INCB028050

     A JAK1 and JAK2 inhibitor
  9. GC15980 WP1066

    (2E)-3-(6-溴-2-吡啶基)-2-氰基-N-[(1S)-1-苯基乙基]-2-丙烯酰胺

    An inhibitor of STAT3
  10. GC16828 Tofacitinib (CP-690550,Tasocitinib)

    托法替尼; Tasocitinib; CP-690550

     Tofacitinib (CP-690550,Tasocitinib) 是一种口服的 JAK3/2/1 抑制剂，IC50 分别为 1、20 和 112 nM。
  11. GC12504 AZD1480

    5-氯-N2-[(1S)-1-(5-氟-2-嘧啶基)乙基]-N4-(5-甲基-1H-吡唑-3-基)-2,4-嘧啶二胺,AZD 1480

     A potent JAK2 inhibitor
  12. GC14324 TG101348 (SAR302503)

    N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-[2-(1-吡咯烷基)乙氧基]苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺,Tg-101348,SAR-302503

     A JAK2 inhibitor
  13. GC17586 Tofacitinib (CP-690550) Citrate

    枸橼酸托法替尼; Tasocitinib citrate; CP-690550 citrate

     A pan-JAK inhibitor
  14. GC17836 ITF2357 (Givinostat)

    N-[4-[(羟基氨基)羰基]苯基]氨基甲酸[6-[(二乙基氨基)甲基]-2-萘基]甲酯盐酸盐水合物,ITF-2357, Givinostat (hydrochloride monohydrate)

    HDAC inhibitor with anti-inflammatory and antineoplastic activities
  15. GC16008 CUDC-101

    7-[[4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基]氧基]-N-羟基庚酰胺,CUDC101, CUDC 101

     A multi-target inhibitor of HDACs, EGFR, and HER2
  16. GC18008 PCI-34051

    N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺,PCI34051, PCI 34051

     A potent, selective HDAC8 inhibitor
  17. GC15476 JNJ-26481585

    JNJ26481585

     A pan-HDAC inhibitor
  18. GC13055 Mocetinostat (MGCD0103, MG0103)

    N-(2-氨基苯基)-4-([[4-(吡啶-3-基)嘧啶-2-基]氨基]甲基)苯甲酰胺,MGCD-0103

     An orally available HDAC inhibitor
  19. GC17390 Vorinostat (SAHA, MK0683)

    伏立诺他; SAHA; Suberoylanilide hydroxamic acid

    An HDAC inhibitor
  20. GC14998 Rocilinostat (ACY-1215)

    Ricolinostat

     A selective inhibitor of HDAC6
  21. GC14191 Ruxolitinib (INCB18424)

    芦可替尼; INCB18424

    Ruxolitinib (INCB18424)作为一种抑制剂，能够抑制Janus相关激酶(JAKs)JAK1和JAK2, IC50 分别为 3.3 nM 和 2.8 nM，Ruxolitinib介导对造血和免疫功能重要的若干细胞因子和生长因子信号。
  22. GC12422 ABT-888 (Veliparib)

    维利帕尼; ABT-888

    ABT-888 (Veliparib) (ABT-888) 是一种有效的 PARP 抑制剂，抑制 PARP1 和 PARP2，Kis 分别为 5.2 和 2.9 nM。
  23. GN10442 Curculigoside

    仙茅苷

     仙茅苷是 C. 中的主要皂苷。
  24. GN10518 Chitosamine hydrochloride

    盐酸氨基葡萄糖; D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride

     An amino monosaccharide
  25. GN10669 Glucosamine sulfate

    硫酸氨基葡萄糖; D-Glucosamine sulfate

     氨基葡萄糖硫酸盐（D-氨基葡萄糖硫酸盐）是一种氨基糖，是糖基化蛋白质和脂质生化合成的重要前体，用作膳食补充剂。
  26. GN10030 Fisetin

    漆黄素

     Fisetin是一种天然黄酮醇，存在于许多水果和蔬菜中，具有多种生物活性。
  27. GN10629 5,7-dihydroxychromone

    5,7-二羟基色酮

     A flavone decomposition product with diverse biological activities
  28. GN10413 Agrimol B

    仙鹤草酚 B

     A polyphenol with adipogenesis inhibitory and anticancer activities
  29. GN10114 Oroxin A

    千层纸苷A

     A flavonoid glycoside
  30. GN10627 Atractylenolide I

    白术内酯 I

     A sesquiterpene with diverse biological activities
  31. GN10040 Dehydrocorydaline

    脱氢紫堇碱; 13-Methylpalmatine

     An alkaloid with diverse biological activities
  32. GN10420 Ophiopogonin D'

    麦冬皂苷 D'

     A steroid glycoside with diverse biological activities
  33. GN10584 Ginsenoside Rk1

    人参皂苷

     人参皂甙 Rk1 是通过在高温下加工人参植物（主要是 Sung Ginseng，SG）而产生的独特成分 。
  34. GN10473 Ginkgolide C

    银杏内酯C,BN-52022; Ginkgolide-C

     A PAF receptor antagonist
  35. GN10308 Chlorogenic acid

    绿原酸; 3-O-Caffeoylquinic acid; Heriguard; NSC-407296

     Chlorogenic acid是一种有效的神经保护剂，同时具有抗病毒、抗真菌、抗氧化和抗肿瘤作用。Chlorogenic acid还参与调节葡萄糖和脂质代谢，改善胰岛素敏感性。
  36. GN10452 Paeoniflorin

    芍药苷; Peoniflorin

     A monoterpene glycoside with diverse cellular actions
  37. GN10347 Nicotinamide (Vitamin B3)

    烟酰胺; Niacinamide; Nicotinic acid amide

     Nicotinamide (Vitamin B3)是维生素B3的酰胺衍生物，可以抑制SIRT1（IC50：50-180μM）和SIRT2（IC50：2μM）的活性。Nicotinamide还可增加细胞中NAD+、ATP、ROS水平。
  38. GN10357 Parthenolide

    小白菊内酯; (-)-Parthenolide

     A natural inhibitor of NOD2 and NF-κB signaling
  39. GC13822 (-)-JQ1

    (S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂卓-6-基)乙酸叔丁酯,(-)-JQ1

     A selective inhibitor of BET bromodomains
  40. GC12961 Apicidin

    OSI 2040

    A cell-permeable HDAC inhibitor
  41. GC11334 Romidepsin (FK228, depsipeptide)

    罗米地辛; FK 228; FR 901228; NSC 630176

     A class I HDAC inhibitor
  42. GC15526 Trichostatin A (TSA)

    曲古抑菌素A; TSA

     Trichostatin A (TSA) 是一种有效的组蛋白脱乙酰酶 (HDAC) 抑制剂和抗真菌抗生素，对 HDAC 的 IC50 值为 1.8 nM，具有抑制细胞生长和诱导细胞分化。
  43. GC17907 3-Deazaneplanocin A (DZNep) hydrochloride

    3-去氮腺嘌呤A盐酸盐; DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride

     3-Deazaneplanocin A (DZNep) hydrochloride 是一种腺苷类似物，是一种竞争性 S-腺苷高半胱氨酸水解酶抑制剂，在无细胞试验中的 Ki 为 50 pM。
  44. GC12257 Panobinostat (LBH589)

    帕比司他; LBH589; NVP-LBH589

     A pan-HDAC inhibitor
  45. GC11625 Entinostat (MS-275,SNDX-275)

    恩替诺特; MS-275; SNDX-275

     A histone deacetylase inhibitor
  46. GC12153 Zebularine

    2-嘧啶酮-B-核甙,NSC 309132

     A DNA methyltransferase inhibitor
  47. GC15610 UNC0638 A G9a and GLP histone methyltransferase inhibitor
  48. GC13398 RG 108

    N-Phthalyl-L-tryptophan,RG108

     DNA methyltransferase inhibitor
  49. GC11778 Lomeguatrib

    罗米鲁曲,PaTrin-2

    Inactivator of O6-methylguanine-DNA methyltransferase
  50. GC16531 Bromodomain Inhibitor, (+)-JQ1

    (S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂卓-6-基)乙酸叔丁酯

     A selective inhibitor of BET bromodomains
  51. GC12171 BIX 01294 An inhibitor of G9a histone methyltransferase

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