Chromatin/Epigenetics(染色质/表观遗传学)
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Products for Chromatin/Epigenetics
- Bromodomain(47)
- Aurora Kinase(57)
- DNA Methyltransferase(32)
- HDAC(176)
- Histone Acetyltransferases(71)
- Histone Demethylases(99)
- Histone Methyltransferase(204)
- HIF(91)
- JAK(154)
- MBT Domains(1)
- PARP(104)
- Pim(27)
- Protein Ser/Thr Phosphatases(31)
- RNA Polymerase(6)
- Sirtuin(70)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(21)
- Epigenetic Reader Domain(205)
- MicroRNA(20)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(42)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Cat.No. 产品名称 Information
-
GC17275
AMI-1
猩红酸钠盐,Arginine N - methyltransferase inhibitor - 1
A cell permeable inhibitor of PRMTs
-
GC10946
5-Azacytidine
5-氮杂胞苷; Azacitidine; 5-AzaC; Ladakamycin
5-氮胞苷（也称为 5-AzaC）是一类胞嘧啶类似物的化合物，是一种 DNA 甲基转移酶 (DNMT) 抑制剂，对多发性骨髓瘤 (MM) 细胞（包括 MM.1S）具有强效细胞毒性, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40和Patient-derived MM,半数抑制浓度IC50值分别为1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L , 分别为 3.2 μmol/L 和 1.5 μmol/L . 5-氮胞苷掺入细胞 DNA 和/或 RNA，随后螯合 DNMT 并在 5-氮胞苷的 C6 和半胱氨酸之间形成共价键DNMT 的硫醇盐导致细胞中 DNMT 活性的耗竭和细胞 DNA 的去甲基化 。
-
GC15255
Decitabine(NSC127716, 5AZA-CdR)
地西他滨; 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716
地西他滨(Decitabine, DAC)是一种具有口服生物活性的脱氧胞苷类似物抗代谢物,具有DNA甲基转移酶抑制剂的功能。
-
GC13145
3-Deazaneplanocin,DZNep
3-去氮腺嘌呤A; DZNep; 3-Deazaneplanocin
An inhibitor of lysine methyltransferase EZH2
-
GP10020
Histone-H2A-(107-122)-Ac-OH
Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH
Histone-H2A peptide
