Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC61468 MR837
4-氰基-N-环丙基-N-(噻吩-2-基甲基)苯甲酰胺
MR837是一种NSD2-PWWP1的抑制剂。MR837可以与人核受体结合SET结构域蛋白(PWWP结构域)结合。
GC48967 D-Homoserine lactone
D-HSL
An enantiomer of L-homoserine lactone
GC48805 Methapyrilene (hydrochloride)
盐酸美沙吡林,Thenylpyramine hydrochloride
An H₁ receptor antagonist and non-genotoxic carcinogen
GC48775 AES-350 An inhibitor of class I and class IIb HDACs
GC48620 BPKDi A PKD inhibitor
GC48600 Panobinostat-d4 (hydrochloride)
LBH589-d4 hydrochloride; NVP-LBH589-d4 hydrochloride
An internal standard for the quantification of panobinostat
GC48548 iBET-BD2
iBET-BD2
A BD2 bromodomain inhibitor
GC48495 BMS-P5 A PAD4 inhibitor
GC48463 Bisubstrate Inhibitor 78 An inhibitor of NNMT
GC48460 NR-160 An inhibitor of HDAC6
GC48408 TW9 A dual inhibitor of BRD4 and HDAC1
GC48382 Ac-QPKK(Ac)-AMC
Ac-Gln-Pro-Lys-Lys-(Ac)-AMC, Ac-Gln-Pro-Lys-Lys-(Ac)-7-amino-4-methylcoumarin, p53317-320 Substrate (Ac-QPKK(Ac)-AMC)
A fluorogenic substrate for SIRT1, SIRT2, and SIRT3
GC50721 iP300w Potent p300/CBP inhibitor
GC50699 SGC 6870 Potent and selective protein arginine methyltransferase 6 (PRMT6) inhibitor (IC50 = 77 nM)
GC50697 GSK 591 dihydrochloride A chemical probe for PRMT5
GC50659 BIX NHE1 inhibitor BIX NHE1 inhibitor 是有效的钠氢交换异构体 1 (NHE1) 抑制剂，在细胞内 pH 恢复 (pHi) 和人血小板肿胀试验中的 IC50 分别为 6 和 31 nM。
GC48263 YW3-56 (hydrochloride) (technical grade) A PAD2 and PAD4 inhibitor
GC48084 Sodium 4-Phenylbutyrate-d11
4-PBA-d11 sodium; 4-Phenylbutyric acid-d11 sodium; Benzenebutyric acid-d11 sodium
An internal standard for the quantification of sodium 4-phenylbutyrate
GC48066 SAHO2 A radical SAM enzyme substrate
GC48065 SAHO A radical SAM enzyme substrate
GC47693 m-Methoxybenzamide
3-甲氧基苯甲酰胺,3-MBA
A PARP inhibitor
GC47586 Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) An LSD1 inhibitor
GC47579 L-Pyrohomoglutamic Acid
(S)-2-哌啶酮-6-羧基酸
An amino acid building block
GC47450 IL-4 Inhibitor An IL-4 inhibitor
GC47439 Hydralazine-d4 (hydrochloride)
盐酸肼屈嗪 d4 (盐酸盐)
A neuropeptide with diverse biological activities
GC47432 Histone H3 (69-89) amide (human, mouse, rat, bovine) (trifluoroacetate salt)
RLVREIAQDFKTDLRFQSSAV-NH2
A neuropeptide with diverse biological activities
GC47294 Entacapone-d10
恩他卡朋 d10
An internal standard for the quantification of entacapone
GC47180 Decitabine-15N4
5-aza-2’-Deoxycytidine-15N4, DAC-15N4
A neuropeptide with diverse biological activities
GC47056 CAY10753 A TNKS2 inhibitor
GC47055 CAY10749 A dual inhibitor of PARP and PI3K
GC47050 CAY10727 A PAD3 inhibitor
GC46935 Bobcat 339
BC339
A cytosine derivative
GC46900 AZ9482 A PARP inhibitor
GC46892 ATRA-BA Hybrid A prodrug form of all-trans retinoic acid and butyric acid
GC46736 7-Bromoheptanoic Acid
7-溴庚酸
A building block
GC46675 4-Phenyl-2-pyrrolidinone
4-苯基-2-吡咯烷酮
A precursor and synthetic intermediate
GC46628 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
4-氯-6,7-二(2-甲氧基乙氧基)喹唑啉
A building block and synthetic intermediate
GC46607 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
4-甲基亚硝胺基-1-3-吡啶基-1-丁酮(NNK),NNK
A tobacco-specific nitrosamine carcinogen
GC46508 2',2'-Difluoro-2'-deoxyuridine
2'-脱氧-2',2'-二氟尿嘧啶核苷
An active metabolite of gemcitabine
GC46503 2-(1,8-Naphthyridin-2-yl)phenol
3-氨基-2-氯-6-三氟甲基吡啶
An enhancer of STAT1 activity
GC61279 SIRT-IN-3
2-(苯基氨基)苯甲酰胺
SIRT-IN-3是一种有效的SIRT抑制剂，对SIRT1的IC50为17μM。SIRT-IN-3对SIRT1的选择性分别是SIRT-2和SIRT3的4倍和14倍(IC50forSIRT2=74μM;IC50forSIRT3=235μM)。
GC61212 PROTAC BRD4 Degrader-5 PROTACBRD4Degrader-5是一种基于PROTAC的BRD4降解剂，可有效降解HER2阳性和阴性乳腺癌细胞系中的BRD4。
GC61142 NSC745885 NSC745885是一种有效的抗肿瘤(anti-tumor)试剂，对多种癌细胞株有选择性毒性，但对正常细胞没有毒性。NSC745885是一种有效的EZH2的下调因子通过蛋白酶体降解途径。NSC745885为晚期膀胱癌和口腔鳞癌的研究提供了可能性。
GC61058 Metoprine
氯苯氨啶,BW 197U
Metoprine(BW197U)是一种有效的组胺N-甲基转移酶(HMT)抑制剂。Metoprine是一种二氨基嘧啶衍生物，可以透过血脑屏障，并通过抑制HMT增加脑组胺水平。Metoprine是一种抗叶酸(antifolate)和抗肿瘤药。
GC61029 Marein
马里甙
A glucoside chalcone with diverse biological activities
GC60925 IACS-9571 hydrochloride
ASIS-P040 hydrochloride
IACS-9571(ASIS-P040)hydrochloride是溴结构域蛋白TRIM24和BRPF1的抑制剂，对TRIM24的IC50和Kd值分别为8nM和31nM，对BRPF1的Kd值为14nM。
GC60919 Hydroxycitric acid tripotassium hydrate
三水合钾柠檬酸; Potassium citrate monohydrate
Hydroxycitricacidtripotassiumhydrate(Potassiumcitratemonohydrate)是藤黄果的主要活性成分，也是柠檬酸的衍生物。Hydroxycitricacidtripotassiumhydrate可竞争性抑制柠檬酸裂解酶(ATPcitratelyase)，并具有减肥效果。Hydroxycitricacidtripotassiumhydrate有效抑制结石形成并抑制HIF，具有抗氧化，抗炎和抗肿瘤作用。
GC60833 FB23 FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.
GC60579 Amodiaquine dihydrochloride
盐酸阿莫地喹,Amodiaquin dihydrochloride
A prodrug form of N-desethyl amodiaquine
GC18750 NEO2734
EP31670
NEO2734 (EP31670) 是一种口服有效的双重 p300/CBP 和 BET 溴结构域选择性抑制剂，对 p300/CBP 和 BET 溴结构域的 IC50 值均 <30 nM。 NEO2734 在 SPOP 突变型和野生型前列腺癌中具有活性。