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Home >> Signaling Pathways >> Chromatin/Epigenetics >> HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Products for  HDAC

  1. Cat.No. 产品名称 Information
  2. GC43201 CAY10722 A SIRT3 inhibitor
  3. GC43200 CAY10721 An inhibitor of SIRT3
  4. GC43147 CAY10398

    MD 85, PX 089274

     A potent, cost-effective histone deacetylase inhibitor
  5. GC41495 HDAC3 Inhibitor

    Histone Deacetylase 3

     An allosteric HDAC3 inhibitor
  6. GC41085 HDAC6 Inhibitor

    Histone Deacetylase 6

     An inhibitor of HDAC6
  7. GC40923 BRD4884 A kinetically selective HDAC2 inhibitor
  8. GC40674 APHA Compound 8

    组蛋白去乙酰化酶

     A class I and II HDAC inhibitor
  9. GC34629 J22352 J22352是一种具有类似靶向嵌合体蛋白水解(PROTAC)特性、高度选择性HDAC6抑制剂，其IC50值为4.7nM，J22352通过抑制胶质母细胞瘤自噬、诱发抗肿瘤免疫反应来促进HDAC6降解和诱导抗癌效果，并通过降低PD-L1的免疫抑制活性，使宿主抗肿瘤活性恢复。
  10. GC34458 ACY-1083

    ACY-1083是一种可渗透脑的选择性HDAC6抑制剂，IC50为3nM，ACY-1083对HDAC6的选择性比其他类别的HDAC亚型高260倍。ACY-1083可有效逆转化疗引起的周围神经病变。
  11. GC40094 all-trans Retinoic Acid-d5

    atRA-d5, RA-d5, Vitamin A Acid-d5

     An internal standard for the quantification of all-trans retinoic acid
  12. GC34165 Corin Corin是组氨酸赖氨酸特异性去甲基化酶(LSD1)和组氨酸脱乙酰化酶(HDAC)的双重抑制剂，其对LSD1的Ki(inact)值为110nM，对HDAC1的IC50值为147nM。
  13. GC33395 HDAC-IN-5 HDAC-IN-5是组蛋白去乙酰化酶(HDAC)的一个抑制剂。
  14. GC33331 BRD 4354 BRD4354是HDAC5和HDAC9适度抑制剂，其IC50值分别为0.85，1.88μM。
  15. GC33317 HDAC6-IN-1 SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.
  16. GC33290 Remetinostat (SHP-141)

    SHP-141

     Remetinostat (SHP-141) (SHP-141) 是一种基于异羟肟酸的组蛋白脱乙酰酶 (HDAC) 抑制剂，正在开发用于治疗皮肤 T 细胞淋巴瘤。
  17. GC33159 Givinostat hydrochloride (ITF-2357 hydrochloride)

    ITF-2357 hydrochloride

     HDAC inhibitor with anti-inflammatory and antineoplastic activities
  18. GC33115 Pomiferin (NSC 5113)

    橙桑黄酮; NSC 5113

    Pomiferin (NSC 5113) (NSC 5113) 作为 HDAC 的潜在抑制剂，其 IC50 为 1.05 μM，并且还有效抑制 mTOR (IC50, 6.2 μM)。
  19. GC33050 Givinostat (ITF-2357)

    [4-[(羟基氨基)羰基]苯基]氨基甲酸[6-[(二乙基氨基)甲基]-2-萘基]甲酯,ITF-2357

     HDAC inhibitor with anti-inflammatory and antineoplastic activities
  20. GC32964 NKL 22

    Histone Deacetylase Inhibitor IV

     A selective HDAC1/3 inhibitor
  21. GC32565 CRA-026440 CRA-026440 是一种有效的广谱 HDAC 抑制剂。
  22. GC31511 Sinapinic acid (Sinapic acid)

    芥子酸; Sinapic acid

     A phenylpropanoid hydroxycinnamic acid with diverse biological activities
  23. GC30782 ACY-775 An HDAC6 inhibitor
  24. GC30763 Benzenebutyric acid (4-Phenylbutyric acid)

    4-苯基丁酸; 4-PBA; Benzenebutyric acid

    4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.
  25. GC30526 ACY-957 ACY-957是一种选择性的HDAC1和HDAC2抑制剂，对HDAC1/2/3的IC50值分别为7nM，18nM和1300nM，对HDAC4/5/6/7/8/9无作用。
  26. GC19406 TH34 TH34 是一种 HDAC6/8/10 抑制剂，IC50 分别为 4.6 μM、1.9 μM 和 7.7 μM，对 HDAC1/2/3 具有高选择性。
  27. GC19360 TMP195

    TMP195游离态

    TMP195 是一种有效的选择性 IIa 类 HDAC 抑制剂，对 HDAC4、HDAC5、HDAC7 和 HDAC9 的 IC50 分别为 59 nM、60 nM、26 nM 和 15 nM。
  28. GC19337 SR-4370 An HDAC3 inhibitor
  29. GC19190 HDAC-IN-4

    CXD101

     An HDAC inhibitor
  30. GC19189 HDAC8-IN-1

    MDK-7933

     An HDAC8 inhibitor
  31. GC19129 EDO-S101

    Tinostamustine

     An HDAC inhibitor and DNA alkylating agent
  32. GC19020 ACY-738

    N-羟基-2-[(1-苯基环丙基)氨基]-5-嘧啶甲酰胺

     An HDAC6 inhibitor
  33. GC18915 Trapoxin A Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor.
  34. GC18402 GSK3117391 An HDAC inhibitor
  35. GC18206 WT161 A potent inhibitor of HDAC6
  36. GC13088 BRD6688 A kinetically selective HDAC2 inhibitor
  37. GC14016 Sulforaphane

    萝卜硫素

    萝卜硫素 (SFN) 称为 [1-isothiocyanato-4-(methylsulfinyl)butane]。
  38. GC17005 4-iodo-SAHA

    ISAHA

     A potent SAHA analog
  39. GC14597 ITSA-1 (ITSA1)

    ITSA-1 是一种组蛋白去乙酰化酶（HDAC）激活剂，能够抑制HDAC抑制剂TSA对HDAC的抑制，但不抑制其他HDAC抑制剂。
  40. GC17472 Oxamflatin

    Metacept-3

     Inhibitor of histone deacetylases
  41. GC12976 Suberohydroxamic Acid

    软木肟酸,Suberohydroxamic acid; SBHA

     HDAC inhibitor
  42. GC11249 2-hexyl-4-Pentynoic Acid

    2-正己基-4-戊炔酸,(±)-2-Hexyl-4-pentynoic acid

     An HDAC inhibitor
  43. GC12822 BML-210(CAY10433)

    NphenylN'(2Aminophenyl)hexamethylenediamide, CAY10433

     A potent, synthetic HDAC inhibitor
  44. GC14367 UF 010 A class I HDAC inhibitor
  45. GC12074 BG45 A selective HDAC3 inhibitor
  46. GC10417 ACY-241

    西他司他,Citarinostat

     An HDAC6 inhibitor
  47. GC16042 Chidamide

    西达本胺,Chidamide impurity

     An HDAC inhibitor
  48. GC12484 BRD73954 A dual inhibitor of HDAC6 and HDAC8
  49. GC11574 HPOB A potent and selective inhibitor of HDAC6
  50. GC12971 CAY10603

    BML-281

     An exceptionally potent inhibitor of HDAC6
  51. GC14439 Santacruzamate A (CAY10683)

    HDAC抑制剂,CAY-10683

     A histone deacetylase inhibitor

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