Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

qq在线咨询
Home >> Signaling Pathways >> Chromatin/Epigenetics >> HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Products for  HDAC

  1. Cat.No. 产品名称 Information
  2. GC13926 BMS-345541(free base) BMS-345541(free base) 是 IKK 催化亚基的选择性抑制剂 (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM)。 BMS-345541（游离碱）结合在 IKK 的变构位点。
  3. GC12667 4SC-202

    4SC-202(盐的形式),4SC-202

     An HDAC1-3 and KDM1A inhibitor
  4. GC13764 Nexturastat A A potent, cell-permeable HDAC6 inhibitor
  5. GC15857 Sodium butyrate

    丁酸钠

     A short-chain fatty acid and HDAC inhibitor
  6. GC15410 Bufexamac

    丁苯羟酸; Bufexamic acid

     An NSAID and a class IIb HDAC inhibitor
  7. GC11424 Valproic acid

    丙戊酸; VPA; 2-Propylpentanoic Acid

     A class I HDAC inhibitor
  8. GC16143 Varenicline Hydrochloride

    6,7,8,9-四氢-6,10-甲桥-6H-吡嗪并[2,3-H][3]苯并氮杂卓盐酸盐,CP 526555 hydrochloride

     Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。
  9. GC17703 TMP269

    TMP 269;TMP-269

     A selective class IIa HDAC inhibitor
  10. GC14285 RGFP966

    RGFP 966;RGFP-966

     RGFP966是一种N-(o-aminophenyl)carboxamide HDAC抑制剂，对HDAC3的IC50为0.08 μM，是一类针对HDAC3的慢开/慢关竞争性紧密结合抑制剂。
  11. GC10322 Tubastatin A HCl

    TubastatinA盐酸盐,TSA HCl;Tubastatin A hydrochloride

     A potent HDAC6 inhibitor
  12. GC12019 TCS HDAC6 20b An HDAC6 inhibitor
  13. GC13237 LMK 235

    N-[[6-(羟基氨基)-6-氧代己基]氧基]-3,5-二甲基-苯甲酰胺

     A selective inhibitor of HDAC4 and HDAC5
  14. GC16386 Tubacin

    HDAC6抑制剂

     Tubacin (tubulin acetylation inducer)是一种选择性抑制组蛋白去乙酰化酶6 (HDAC6)，诱导α-微管蛋白乙酰化的小分子，IC50为0.004µM。
  15. GC13591 TC-H 106

    RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII

     A tight-binding inhibitor of class I HDACs
  16. GC11095 Pyroxamide

    N-羟基-N'-3-吡啶基辛二酰胺

     A HDAC inhibitor
  17. GC15040 NSC 3852

    8-羟基-5-硝基喹啉

     A tumor cell differentiating agent
  18. GC15536 NCH 51

    NCH-51

     An HDAC inhibitor
  19. GC13435 KD 5170 An inhibitor of class I and II HDACs
  20. GC14340 Tasquinimod

    他喹莫德; ABR-215050

     An orally-active anti-cancer compound
  21. GC10423 RG2833

    RG 2833;RG-2833;RGFP-109;RGFP109;RGFP 109

     An HDAC inhibitor
  22. GC14243 Resminostat hydrochloride

    RAS2410 hydrochloride;4SC-201 hydrochloride;RAS 2410 hydrochloride;RAS-2410 hydrochloride

     An orally bioavailable HDAC inhibitor
  23. GC15830 Daminozide

    丁酰肼

     Selective inhibitor of KDM2/7 histone demethylases
  24. GC11975 CHAPS

    3-[3-(胆酰胺丙基)二甲氨基]丙磺酸内盐

     CHAPS 是胆酸的衍生物，是一种用于溶解膜蛋白的两性离子去污剂。
  25. GC16456 M344

    4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺,Histone Deacetylase Inhibitor III,MS344

     HDAC inhibitor
  26. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent
  27. GC15114 LAQ824 (NVP-LAQ824,Dacinostat)

    达诺司他,LAQ-824, NVP-LAQ 824

     A hydroxamate-based HDAC inhibitor
  28. GC13408 CI994 (Tacedinaline)

    4-乙酰氨基-N-(2'-氨基苯基)-苯甲酰胺,N-acetyldinaline; CI-994; Goe-5549

     An inhibitor of HDAC1, -2, and -3
  29. GC10839 Tubastatin A Tubastatin A 是一种有效的选择性 HDAC6 抑制剂，IC50 值为 15 nM。并且Tubastatin A也是一种新型GPX4抑制剂，Tubastatin A 直接与 GPX4 结合，诱导乳腺癌细胞铁死亡。
  30. GC13706 Droxinostat

    4-(4-氯-2-甲基苯氧基)-N-羟基丁酰胺,NS 41080

     An inhibitor of HDAC3, HDAC6, and HDAC8
  31. GC15794 Valproic acid sodium salt (Sodium valproate)

    丙戊酸钠; Sodium Valproate sodium

     Valproic acid sodium salt (Sodium valproate)（VPA）是一种具有口服活性的组蛋白脱乙酰酶 （HDAC）抑制剂，IC50 值为1.5mM，抑制HDAC1的IC50值为400μM，同时可诱导HDAC2的降解。
  32. GC14682 PCI-24781 (CRA-024781)

    阿贝司他; 艾贝司他; CRA 024781; PCI-24781

     An HDAC inhibitor
  33. GC12115 CUDC-907

    CUDC-907

     CUDC 是一种口服生物可利用的小分子 PI3K 和 HDAC 双重抑制剂，作用于 PI3K α 和 HDAC1 / 2 / 3 / 10，IC50 分别为 19 nm 和 1.7 nm / 5 nm / 1.8 nm / 2.8 nm .在 WSU DLCL2 细胞中评估了双功能 HDAC 和 PI3K 抑制剂 CUDC-907 的抗肿瘤活性。
  34. GC15962 Belinostat (PXD101)

    贝利司他(PXD101),PXD-101, PXD 101, PX105684, PX-105684

     Belinostat (PXD101) 是 HeLa 细胞提取物中组蛋白脱乙酰酶 (HDAC) 活性的新型异羟肟酸型抑制剂，IC50 为 27 nM 。
  35. GC16734 Pracinostat (SB939)

    (2E)-3-[2-丁基-1-[2-(二乙基氨基)乙基]-1H-苯并咪唑-5-基]-N-羟基丙烯酰胺,SB-939, SB 939

    A pan-HDAC inhibitor
  36. GC15965 MC1568

    MC 1568, MC-1568

     A selective class IIa HDAC inhibitor
  37. GC15879 Resminostat (RAS2410)

    RAS2410; 4SC-201

     Resminostat (RAS2410) (RAS2410; 4SC-201) 是一种有效的 HDAC1、HDAC3 和 HDAC6 抑制剂，平均 IC50 值分别为 42.5、50.1、71.8 nM，对 HDAC8 的活性较低，IC50 为 877 nM .
  38. GC15002 Sodium Phenylbutyrate

    苯丁酸钠; 4-PBA sodium; 4-Phenylbutyric acid sodium; Benzenebutyric acid sodium

     A chemical chaperone
  39. GC15315 Scriptaid

    Scriptide; GCK1026

     HDAC inhibitor
  40. GC17836 ITF2357 (Givinostat)

    N-[4-[(羟基氨基)羰基]苯基]氨基甲酸[6-[(二乙基氨基)甲基]-2-萘基]甲酯盐酸盐水合物,ITF-2357, Givinostat (hydrochloride monohydrate)

    HDAC inhibitor with anti-inflammatory and antineoplastic activities
  41. GC16008 CUDC-101

    7-[[4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基]氧基]-N-羟基庚酰胺,CUDC101, CUDC 101

     A multi-target inhibitor of HDACs, EGFR, and HER2
  42. GC18008 PCI-34051

    N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺,PCI34051, PCI 34051

     A potent, selective HDAC8 inhibitor
  43. GC15476 JNJ-26481585

    JNJ26481585

     A pan-HDAC inhibitor
  44. GC13055 Mocetinostat (MGCD0103, MG0103)

    N-(2-氨基苯基)-4-([[4-(吡啶-3-基)嘧啶-2-基]氨基]甲基)苯甲酰胺,MGCD-0103

     An orally available HDAC inhibitor
  45. GC17390 Vorinostat (SAHA, MK0683)

    伏立诺他; SAHA; Suberoylanilide hydroxamic acid

    An HDAC inhibitor
  46. GC14998 Rocilinostat (ACY-1215)

    Ricolinostat

     A selective inhibitor of HDAC6
  47. GN10357 Parthenolide

    小白菊内酯; (-)-Parthenolide

     A natural inhibitor of NOD2 and NF-κB signaling
  48. GC12961 Apicidin

    OSI 2040

    A cell-permeable HDAC inhibitor
  49. GC11334 Romidepsin (FK228, depsipeptide)

    罗米地辛; FK 228; FR 901228; NSC 630176

     A class I HDAC inhibitor
  50. GC15526 Trichostatin A (TSA)

    曲古抑菌素A; TSA

     Trichostatin A (TSA) 是一种有效的组蛋白脱乙酰酶 (HDAC) 抑制剂和抗真菌抗生素，对 HDAC 的 IC50 值为 1.8 nM，具有抑制细胞生长和诱导细胞分化。
  51. GC12257 Panobinostat (LBH589)

    帕比司他; LBH589; NVP-LBH589

     A pan-HDAC inhibitor

Items 151 to 200 of 201 total

per page
  2. 1
  3. 2
  4. 3
  5. 4
  6. 5

Set Descending Direction