Histone Acetyltransferases(组蛋白乙酰转移酶)
Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.
Products for Histone Acetyltransferases
- Cat.No. 产品名称 Information
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GC31099
YF-2
A HAT activator
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GC30714
GSK4028
GSK4028是GSK4027的对映体阴性对照,GSK4027是一种PCAF/GCN5溴结构域的化学探针,而GSK4028对应的pIC50值为4.9。
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GC18154
WM-1119
An inhibitor of KAT6A
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GC18153
WM-8014
WM8014,WM 8014
An inhibitor of KAT6A and KAT6B -
GC14524
CTPB
A selective activator of p300 HAT
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GC12009
HAT Inhibitor II
组蛋白乙酰转移酶抑制剂II,Histone Acetyltransferase Inhibitor II
An inhibitor of HAT p300 -
GC10226
Butyrolactone 3
丁内酯 3; MB-3
A HAT inhibitor -
GC14428
CPTH2 (hydrochloride)
A HAT inhibitor
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GC14103
NSC228155
An EGFR activator and inhibitor of KID-KIX interactions
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GC10382
CPI-637
An inhibitor of CBP/EP300 bromodomains
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GC15049
MCB-613
4-乙基-2,6-双(吡啶-3-基亚甲基)环己酮
A small molecule stimulator of SRCs -
GC13474
Garcinol
山竹子素
Garcinol是组蛋白乙酰转移酶p300和PCAF的非特异性抑制剂,IC50分别为7μM和5μM。
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GC15836
IWP 12
Inhibitor of Wnt Production-12
A PORCN inhibitor -
GC11430
Remodelin
Remodelin 是 N-乙酰转移酶 10 (NAT10) 的小分子抑制剂。
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GC15731
L002
p300/CBP Inhibitor VI, NSC 764414
A p300 acetyltransferase inhibitor -
GC15104
(R)-(+)-Etomoxir sodium salt
(R)-(+)-乙莫克舍钠盐,(R)-(+)-Etomoxir sodium salt
(R)-(+)-Etomoxir sodium salt(Etomoxir; ETO)是一种用于代谢和心血管疾病的小分子,经酶转化为活性抑制剂乙托莫西里尔辅酶a (IC50 约为0.01-0.70 µM)后,对CPT-1a和CPT-1b的抑制表现出纳摩尔效价。 -
GC12934
YM 750
YM 750 是一种有效的 acyl-CoA:cholesterol acyltransferase (ACAT) 抑制剂 (IC50\u003d0.18 μM)。
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GC10931
VULM 1457
VULM 1457 是一种有效的胆固醇酰基转移酶 (acyl-CoA) 抑制剂。
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GC11539
CI 976
CI 976
An inhibitor of ACAT-1 -
GC12917
Acetaminophen
对乙酰氨基酚; Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide
An analgesic and antipyretic compound
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GC12733
C646
C646是一种有效的选择性p300/CBP组蛋白乙酰转移酶抑制剂(Ki 400 nM),已被证明具有多效性,包括神经保护、抗癌和抗上皮间质转化(anti-EMT)作用。
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GC14490
Donepezil HCl
盐酸多奈哌齐; E2020
An AChE inhibitor -
GC11439
MG 149
Tip60 HAT inhibitor
A HAT inhibitor -
GC11972
NU 9056
NU 9056 是一种有效且选择性的 Tip60 (KAT5) 组蛋白乙酰转移酶抑制剂,浓度为 2 µM。 NU 9056 对 Tip60 的选择性比 PCAF、p300 和 GCN5 高 16 倍以上。 NU 9056 诱导前列腺癌细胞凋亡。
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GC10174
SGC-CBP30
SGCCBP30,SGC CBP30
A potent inhibitor of CREBBP/EP300 bromodomains -
GC17284
Anacardic acid
漆树酸; Hydroginkgolic acid; Ginkgolic Acid C15
A histone acetyltransferase inhibitor
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GC14787
Curcumin
姜黄素; Diferuloylmethane; Natural Yellow 3; Turmeric yellow
A yellow pigment with diverse biological activities