Sirtuin(Sirtuin蛋白)

Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.

Products for Sirtuin

Cat.No. 产品名称 Information
GC11716 SIRT1/2 Inhibitor IV
Cambinol,NSC 112546,SIRT1 Inhibitor II,SIRT2 Inhibitor VI
Cell-permeable inhibitor of SIRT1 and SIRT2
GC13062 JGB1741
ILS-JGB-1741
A SIRT1 inhibitor
GC17922 4'-bromo-Resveratrol
5-[(E)-2-(4-溴苯基)乙烯基]间苯二酚,4′‐BR
A potent inhibitor of SIRT1 and SIRT3
GC13942 SirReal2
乙酰胺,2-[(4,6-二甲基-2-嘧啶基)硫]-N-[5-(1-萘甲基)-2-噻唑]-
A selective SIRT2 inhibitor
GC17704 Triacetyl Resveratrol
三乙酰基白藜芦醇
A resveratrol derivative with diverse biological activities
GC17126 EX-527 R-enantiomer
(R)-EX-527
EX-527 R-对映异构体 ((R)-EX-527) 是 Selisstat 的 R-对映异构体。 Selisistat (EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。
GC13417 EX-527 S-enantiomer
(1S)-6-氯-2,3,4,9-四氢-1H-咔唑-1-甲酰胺,(S)-EX-527
EX-527 S-对映异构体 ((S)-EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。
GC14817 Salermide A sirtuin inhibitor
GC17881 AGK 2
2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺
AGK2是一种选择性的SIRT2 抑制剂,IC50为3.5 µM。
GC10676 AK-7
N-(3-溴苯基)-3-[(六氢-1H-氮杂卓-1-基)磺酰基]-苯甲酰胺
An inhibitor of SIRT2
GC14755 Inauhzin
INZ
A selective SIRT1 inhibitor
GC12337 Tenovin-3
Tenovin 3;Tenovin3
A small molecule activator of p53
GC16436 Tenovin-6 A small molecule activator of p53
GC10555 Splitomicin
斯普利特麻一辛
Inhibitor of yeast Sir2p
GC15109 SRT2104 (GSK2245840)
玻玛西林
SRT2104 (GSK2245840) 是 Sirtuin 1 (SIRT1) 的高选择性小分子激活剂，可穿透血脑屏障，减轻脑萎缩，改善运动功能，并防止糖尿病引起的主动脉内皮功能障碍 .用 SRT2104（3µ；M，48 小时）处理可降低 HG 处理的内皮细胞 (EC) 中的 P53 和 Ac-P53 蛋白水平，但不会降低 P53 mRNA 。
GC14165 Tenovin-1 A small molecule activator of p53
GC14945 Sirtinol
2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺
Inhibitor of sirtuin deacetylases
GC14553 Resveratrol
白藜芦醇; trans-Resveratrol; SRT501
白藜芦醇（转-白藜芦醇；SRT501）是一种植物抗菌素。
GC10635 EX 527 (SEN0014196)
EX-527,SIRT1 Inhibitor III,SEN0014196,EX527, Selisistat

EX 527 (SEN0014196) 作为 SIRT1 选择性抑制剂，抑制 Sirt1 的效力比 Sirt2 和 Sirt3 高 100 倍，并且对 Sirt5 的去乙酰化活性没有影响。
GC17101 SRT1720 HCl
SRT-1720,SRT 1720,SRT 1720 Hydrochloride
SRT1720 HCl 是 SIRT1 的激活剂（EC1.5 = 0.16 µ；M 和最大激活 = 781%），一种 NAD+- 依赖性蛋白和组蛋白脱乙酰酶，在许多生物过程。
GN10030 Fisetin
漆黄素
Fisetin是一种天然黄酮醇，存在于许多水果和蔬菜中，具有多种生物活性。
GN10413 Agrimol B
仙鹤草酚 B
A polyphenol with adipogenesis inhibitory and anticancer activities
GN10420 Ophiopogonin D'
麦冬皂苷 D'
A steroid glycoside with diverse biological activities
GN10473 Ginkgolide C
银杏内酯C,BN-52022; Ginkgolide-C
A PAF receptor antagonist
GN10347 Nicotinamide (Vitamin B3)
烟酰胺; Niacinamide; Nicotinic acid amide
Nicotinamide (Vitamin B3)是维生素B3的酰胺衍生物，可以抑制SIRT1（IC₅₀：50-180μM）和SIRT2（IC₅₀：2μM）的活性。Nicotinamide还可增加细胞中NAD⁺、ATP、ROS水平。