GPCR/G protein(G 蛋白偶联受体/G 蛋白)

Cat.No. 产品名称 Information

GC50679 ISAM 140 ISAM 140 (22b) 是一种有效且高度选择性的 A2B 腺苷受体拮抗剂，Ki 为 3.49 nM。

GC50668 PF 04479745 PF 04479745 是一种有效的选择性 5-HT2C 受体激动剂（EC50:10 nM，ki:15 nM）。 PF 04479745 可用于高血压等心血管疾病的研究。

GC50662 DL 175 Potent and selective GPR84 biased agonist (EC50 = 33 nM)

GC50655 AZ 10397767 Potent CXCR2 antagonist (IC50 = 1 nM); attenuates oxaliplatin-induced NF-κB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells

GC48269 Zilpaterol-d7

齐帕特罗-D7

An internal standard for the quantification of zilpaterol

GC48262 YM-90K (hydrochloride hydrate) A neuropeptide with diverse biological activities

GC48255 Vortioxetine-d8

Lu AA 21004 D8

An internal standard for the quantification of vortioxetine

GC48246 VCP171 A positive allosteric modulator of adenosine A₁ receptors

GC48243 Vardenafil-d5

伐地那非-d5杂质17

An internal standard for the quantification of vardenafil

GC48121 Tadalafil-d3

他达拉非-D3,IC-351-d3

An internal standard for the quantification of tadalafil

GC48078 Sildenafil-d3

西地那非-D3,UK-92480-d3

An internal standard for the quantification of sildenafil

GC48067 Salmeterol-d3

沙美特罗-D3

An internal standard for the quantification of salmeterol

GC47923 Paraxanthine-d6

1,7-Dimethylxanthine-d6

An internal standard for the quantification of paraxanthine

GC47866 Palmitoyl Ethanolamide-d5

Palmidrold5, PEA15,15,16,16,16d5

A neuropeptide with diverse biological activities

GC47742 Naled

二溴磷

An organophosphate insecticide and acaricide

GC47645 Methidathion

杀扑磷

An organophosphate insecticide

GC47438 H-Val-Pro-Pro-OH (trifluoroactetate salt)

VPP

A neuropeptide with diverse biological activities

GC47371 Fosinopril-d7 (sodium salt) An internal standard for the quantification of fosinopril

GC47314 Ethopropazine (hydrochloride)

盐酸乙丙嗪,Isothazine hydrochloride; Lysivane hydrochloride; Parsidol hydrochloride

A BChE inhibitor

GC47263 Donecopride (fumarate hydrate)

MR31147

A 5-HT₄ receptor partial agonist and AChE inhibitor

GC47237 Dipyridamole-d16 A neuropeptide with diverse biological activities

GC47211 Dichlorvos

敌敌畏

An organophosphate insecticide

GC47186 Deoxy Donepezil (hydrochloride)

1-苄基-4-((5,6-二甲氧基-2,3-二氢-1H-茚-2-基)甲基)哌啶盐酸盐

A potential impurity found in bulk preparations of donepezil

GC47122 Coumaphos

蝇毒磷

An organophosphate pesticide

GC47088 Cilostazol-d4

西洛他唑-D4,OPC-13013-d4

An internal standard for the quantification of cilostazol

GC46915 Bendiocarb

恶虫威

A broad-spectrum carbamate insecticide

GC46913 Benazepril-d5 (hydrochloride)

贝那普利杂质,CGS14824A-d5 hydrochloride

An internal standard for the quantification of benazapril

GC46898 Avanafil-13C-d3

TA1790-13C,d3

A neuropeptide with diverse biological activities

GC46893 Atranorin

荔枝素

A depside lichen metabolite with diverse biological activities

GC46283 (±)-Clorprenaline-d7

Isoprophenamine-d7

A neuropeptide with diverse biological activities

GC61389 Ziprasidone amino acid

齐拉西酮开环物,氨基酸杂质,Ziprasidone Impurity C; Ziprasidone open ring impurity

Ziprasidoneaminoacid(ZiprasidoneImpurityC)是Ziprasidone的杂质。Ziprasidone是5-HT和多巴胺(dopaminereceptor)受体拮抗剂，具有抗精神病活性。

GC61387 Zamifenacin

UK-76654

A muscarinic M₃ receptor antagonist

GC61378 VU0238441 VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50 of 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and >10 μM for M5, M3, M2, M1 and M4, respectively.

GC61377 VU0119498

1-(4-溴苄基)吲哚-2,3-二酮

An M₁, M₃, and M₅ muscarinic receptor positive allosteric modulator

GC61320 Terazosin dimer impurity dihydrochloride

双盐酸特拉唑嗪杂质

Terazosindimerimpuritydihydrochloride是Terazosin的二聚体，也是Terazosin的杂质。Terazosin是喹唑啉衍生物，是竞争性的，具有口服活性的α1-肾上腺素(α1-adrenoceptor)受体拮抗剂。

GC61281 SKF-83566 A dopamine D₁ receptor antagonist

GC61268 SB 243213 A 5-HT_2C receptor inverse agonist

GC61234 Rebamipide D4

瑞巴派特 D4; OPC12759-d4; Proamipide-d4

An internal standard for the quantification of rebamipide

GC61219 PS372424 hydrochloride PS372424hydrochloride，CXCL10的三个氨基酸片段，是一种特异的人CXCR3激动剂，具有抗炎活性。在关节炎炎症模型中，PS372424hydrochloride可抑制T细胞迁移。

GC61208 Propranolol D7 hydrochloride

盐酸普萘洛尔 d7 (盐酸盐)

PropranololD7hydrochloride是Propranololhydrochloride的氘代物。Propranololhydrochloride是一种非选择性的β-adrenergicreceptor(βAR)拮抗剂，对β1AR和β2AR具有高亲和力，Ki值分别为1.8nM和0.8nM。Propranololhydrochloride抑制[3H]-DHA与大鼠脑膜制剂的结合，IC50为12nM。Propranololhydrochloride用于高血压，嗜铬细胞瘤，心肌梗塞，心律不齐，心绞痛和肥大心肌病的相关研究。

GC61167 Paliperidone palmitate

棕榈酸帕利哌酮,9-Hydroxyrisperidone palmitate

Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.

GC61154 Olmesartan methyl ester

奥美沙坦甲酯

Olmesartanmethylester是Olmesartanmedoxomil合成的中间体。Olmesartanmedoxomil是一种有效的选择性的血管紧张素(angiotensinAT1)受体拮抗剂，IC50为66.2μM。

GC61153 Olmesartan medoxomil impurity C

奥美沙坦酯杂质I,Dehydro Olmesartan medoxomil

OlmesartanmedoxomilimpurityC是Olmesartanmedoxomil的杂质。Olmesartanmedoxomil是一种有效的选择性的血管紧张素(angiotensinAT1)受体抑制剂，IC50为66.2μM。

GC61118 Nebentan potassium

YM598

Nebentanpotassium(YM598)是一种有效的具有口服活性的非肽类内皮素受体(ETAreceptor)拮抗剂，通过Bosentan修饰得到。Nebentanpotassium抑制[125I]内皮素-1与人内皮素ETA和ETB受体结合，Ki分别为0.697nM和569nM。Nebentanpotassium可用于改善肺心病和心肌梗死的相关研究。

GC61108 Naftidrofuryl oxalate

草酸萘呋胺; Nafronyl oxalate salt

Naftidrofuryloxalate(Nafronyloxalatesalt)是在外周血和脑血管病症如血管扩张药的管理中使用的药物,增加细胞氧化能力,且是一种5-HT2受体拮抗剂。

GC61076 MLS000532223

1-(3-硝基苯基)-3-苯基丙-2-炔-1-酮

MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 ranging from 16 μM to 120 μM.

GC61067 Mirtazapine D3

米氮平 D3; Org3770 D3; 6-Azamianserin D3

An Analytical Reference Material

GC60998 LMD-009 LMD-009是选择性CCR8非肽激动剂。LMD-009以高效力介导趋化性，肌醇磷酸盐积累和钙释放，EC50为11至87nM。

GC60971 L-692429

MK-0751

L-692429(MK-0751)是一种苯并内酰胺的衍生物，也是一种非肽基生长激素促分泌素(GHS)激动剂。L-692429以Ki值为63nM来结合G蛋白偶联受体(Gprotein-coupledreceptor)。

GC60969 KRAS inhibitor-9

4-(苯并[D]噻唑-2-基硫基)-3-氯苯胺

KRASinhibitor-9是有效的KRAS抑制剂(Kd=92μM)，阻止GTP-KRAS的形成和KRAS下游激活。KRASinhibitor-9以中等的结合亲和力与KRASG12D，KRASG12C和KRASQ61H蛋白结合。KRASinhibitor-9导致G2/M细胞周期停滞并诱导凋亡(apoptosis)。KRASinhibitor-9选择性抑制具有KRAS突变的NSCLC细胞的增殖，但不抑制正常肺细胞的增殖。KRASinhibitor-9