CXCR(CXC趋化因子受体)

CXCR (CXC chemokine receptor) is a group of receptors that belong to GPCRs and specifically binds and responds to cytokines of the CXC chemokine family.

Products for CXCR

Cat.No. 产品名称 Information
GC19116 Danirixin
GSK1325756
A CXCR2 antagonist
GC17526 BKT140
BKT140 (4-fluorobenzoyl); BL-8040; TF14016
A CXCR4 antagonist
GC14711 ATI-2341
变构激动剂多肽ATI2341
A Gα_i-signaling biased CXCR4 agonist
GC17538 UNBS 5162 A antagonist of CXCL chemokine expression
GC16465 SB 225002 SB 225002是一种有效的选择性CXCR2趋化因子受体拮抗剂，可抑制¹²⁵I-IL-8（¹²⁵I标记的白细胞介素8）和CXCR2的结合，IC₅₀值为22nM。
GC13458 SB 265610 A selective CXCR2 inverse agonist
GC10432 IT1t dihydrochloride A CXCR4 antagonist
GC17174 ML 145 An antagonist of GPR35
GC12909 Zaprinast
2-(2-丙氧苯基)-8-氮杂次黄嘌呤,M&B 22948
A cGMP phosphodiesterase inhibitor
GC16706 AMD 3465 hexahydrobromide
GENZ-644494 hexahydrobromide
A CXCR4 receptor antagonist
GC10473 AMD 3465
GENZ-644494
A CXCR4 receptor antagonist
GC17949 Plerixafor 8HCl (AMD3100 8HCl)
盐酸普乐沙福; AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride
An antagonist of CXCR4
GC15989 WZ811 CXCR4 antagonist
GC11939 AMG 487
A CXCR3 antagonist
GC14745 Plerixafor (AMD3100)
普乐沙福; AMD 3100; JM3100; SID791
Plerixafor(AMD3100) 是 CXCR4 和 CXCL12 介导的趋化作用的小分子抑制剂，IC50 值分别为 44 nM 和 5.7 nM 。
GC16377 SRT3190
N-[2-[[(2,3-二氟苯基)甲基]硫基]-6-[[(1S,2R)-2,3-二羟基-1-甲基丙基]氨基]-4-嘧啶基]-1-氮杂环丁烷磺酰胺,SRT 3190;SRT-3190
SRT3190 是 CXCR2 的拮抗剂，用于研究趋化因子介导的疾病。
GC16710 SRT3109
SRT 3109;SRT-3109
SRT3109 是 CXCR2 的拮抗剂，pIC50 为 8.2，用于研究趋化因子介导的疾病。
GC15401 SCH 563705
3-[[3-[(二甲氨基)羰基]-2-羟苯基]氨基]-4-[[(R)-1-(4-异丙呋喃-2-基)丙基]氨基]环丁基-3-烯-1,2-二酮,SCH563705;SCH-563705
SCH 563705 是一种有效的、可口服的 CXCR2 和 CXCR1 拮抗剂，IC50 分别为 1.3 nM、7.3 nM 和 Kis 分别为 1 和 3 nM。
GC16100 SCH 527123
3-[[3-[(二甲基氨基)羰基]-2-羟基苯基]氨基]-4-[[(R)-1-(5-甲基呋喃-2-基)丙基]氨基]-3-环丁烯-1,2-二酮,SCH-527123;SCH527123
An allosteric antagonist of CXCR1 and CXCR2
GC13813 Reparixin L-lysine salt
REPERTAXINL-赖氨酸盐,Repertaxin L-lysine salt
Perifosine is an orally active alkyl phospholipid analogue that has shown antitumor activity in a variety of cancers by interfering .
GC12849 Reparixin
瑞帕利辛; Repertaxin; DF 1681Y
An allosteric inhibitor of CXCR1 and CXCR2
GC17018 AMD-070 hydrochloride
N-(1H-苯并咪唑-2-基甲基)-N-[(8S)-5,6,7,8-四氢-8-喹啉基]-1,4-丁二胺单盐酸盐,AMD070 hydrochloride;AMD 070 hydrochloride
CXCR4 antagonist,potent and selective
GC12196 AMD-070
N'-(1H-苯并咪唑-2-甲基)-N'-((S)-5,6,7,8-四氢喹啉-8-基)丁烷-1,4-二胺,AMD 070; AMD070
A CXCR4 antagonist
GN10507 Baohuoside I
宝藿苷 I; Icariin-II; Icariside-II
宝活苷 I 是一种从淫羊藿中分离出来的黄酮类化合物，可作为 CXCR4 抑制剂，下调 CXCR4 表达，诱导细胞凋亡并具有抗肿瘤活性。