MCHR1 (GPR24)(黑色素浓缩激素受体1)

MCHR1 (GPR24), also known as Melanin concentrating hormone receptor 1, belongs to a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone, and is one of the melanin-concentrating hormone receptors found in all mammals. MCHR1 can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. MCHR1 is thought to regulate appetite, and also functions in stress, anxiety and depression.

Products for MCHR1 (GPR24)

Cat.No. 产品名称 Information
GC63822 Ethyl linolenate
亚麻酸乙酯
An esterified form of α-linolenic acid
GC36727 Neuropeptide EI, rat Neuropeptide EI, rat 是一种黑色素聚集激素 (MCH) 拮抗剂，同时是一种黑素细胞刺激素 (MSH) 激动剂。
GC36580 Melanin Concentrating Hormone, salmon (TFA)
MCH (salmon) (TFA)
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是最初在硬骨鱼的垂体中发现的 19 个氨基酸组成的神经肽，它调节食物摄入，能量平衡，睡眠状态和心血管系统。Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是 SLC-1/GPR24 和 MCHR2 的配体。
GC40787 γ-Linolenic Acid ethyl ester
γ-亚麻酸乙酯
Esterified form of γ-linolenic acid
GC31643 AZD1979 AZD1979是一个Melanin-concentratinghormonereceptor1(MCHr1)拮抗剂,其IC50值约为12nM。
GC31628 MCHr1 antagonist 1 MCHr1antagonist1是一种选择性的黑色素浓集激素1型受体(melaninconcentratinghormone-1receptor)拮抗剂，对人MCH1受体的Kb和Ki值分别为1nM和4nM，在降低体重方面可能起作用。
GC31506 SB-568849 SB-568849是一种黑色素浓缩激素受体1(MCHR1)拮抗剂，pKi值为7.7。
GC31505 MCHr1 antagonist 2 MCHr1antagonist2是一种黑色素聚集激素受体1(melaninconcentratinghormonereceptor1)拮抗剂，IC50值为65nM；MCHr1antagonist2同时抑制hERG，在IMR-32细胞中，IC50值为4.0nM。
GC31504 NGD-4715 NGD-4715是选择性，有口服活性的黑色素浓缩激素受体1(melanin-concentratinghormonereceptor1(MCHR1))的拮抗剂。
GC31479 BMS-819881 BMS-819881是一种黑色素浓缩激素受体1(MCHR1)拮抗剂，结合大鼠MCHR1，Ki值为7nM。BMS-819881还有效且选择性地作用于CYP3A4，EC50为13μM.
GC31422 MCH-1 antagonist 1
MCH-1antagonist1是一种有效的黑色素浓缩激素1(MCH-1)拮抗剂，Ki值为2.6nM。MCH-1antagonist1还抑制CYP3A4，IC50为10μM。
GC31388 ALB-127158(a) ALB-127158(a)是一种有效的选择性黑色素浓缩激素1(MCH1)受体拮抗剂。
GC31149 Melanin Concentrating Hormone, salmon (MCH (salmon))
黑色素聚集激素肽,MCH (salmon)
黑色素浓缩激素鲑鱼 (MCH (salmon)) 是一种 19 个氨基酸的神经肽，最初在硬骨鱼的脑垂体中发现，可调节食物摄入、能量平衡、睡眠状态和心血管系统。
GC10175 GW 803430
GW-3430
An antagonist of MCH₁
GC17846 SNAP 94847 hydrochloride An antagonist of MCH₁
GC10865 TC-MCH 7c TC-MCH 7c 是一种苯基吡啶酮衍生物，是一种口服的、选择性的、可穿透脑的 MCH1R 拮抗剂，对 hMCH1R 的 IC50 为 5.6 nM。