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Home >> Signaling Pathways >> Immunology/Inflammation >> Apoptosis

Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Products for  Apoptosis

  1. Cat.No. 产品名称 Information
  2. GC41183 α-Carotene

    α-胡萝卜素

     A precursor of vitamin A
  3. GC45204 α-Ecdysone

    蜕皮激素; α-Ecdysone

     蜕皮激素（α-蜕皮激素）是一种存在于昆虫和植物中的类固醇蜕皮激素，可激活盐皮质激素受体（MR），从而导致肾小球疾病。
  4. GC63941 α-Solanine

    α-茄碱

     α-solanine 是马铃薯中的一种生物活性成分，是主要的甾体类生物碱之一，可抑制癌细胞的生长并诱导其凋亡 (apoptosis)。
  5. GC67618 α-Tocopherol phosphate disodium

    alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium

     α-Tocopherol phosphate (alpha-Tocopherol phosphate) 是一种抗氧化剂，可以保护长波 UVA1 诱导的细胞死亡，并清除 UVA1 诱导的活性氧 (ROS)。α-Tocopherol phosphate disodium 可抑制内皮祖细胞凋亡 (apoptosis)，增加高糖/低氧条件下内皮祖细胞迁移能力，促进血管生成。
  6. GC41623 β-Elemonic Acid

    β-岚香酮酸

     A triterpene with anticancer activity
  7. GC64619 β-Ionone

    β-紫罗兰酮

     β-Ionone 可有效诱导胃腺癌细胞 SGC7901 凋亡 (apoptosis)。具有抗肿瘤活性。
  8. GC72061 β-Phellandrene β-Phellandrene是从岩骨中获得的。
  9. GC45277 (±)-Camphene

    DL-Camphene, NSC 4165

      
  10. GC49268 (+)-δ-Cadinene

    Δ-杜松烯

     A sesquiterpene with antimicrobial and anticancer activities
  11. GC18516 (+)-Aeroplysinin-1

    (+)-Aeroplysinin-1

     A sea sponge metabolite with diverse biological activities
  12. GC45274 (+)-Pinoresinol

    松脂素,(+)-Pinoresinol

     A lignan with diverse biological activities
  13. GC40218 (-)-Epigallocatechin Gallate-d3/d4

    EGCG-d3/d4

     An internal standard for the quantification of (–)-epigallocatechin gallate
  14. GC62193 (1S,2S)-Bortezomib

    硼替佐米杂质E

     (1S,2S)-Bortezomib 是 Bortezomib 的对映异构体。Bortezomib 是一种细胞渗透性、可逆性和选择性的蛋白酶体抑制剂，通过靶向苏氨酸残基有效抑制 20S 蛋白酶体 (Ki 为 0.6 nM)。Bortezomib 破坏细胞周期、诱导细胞凋亡以及抑制核因子 NF-κB。Bortezomib 是一种抗癌药物，也是第一种用于人类的蛋白酶体抑制剂。
  15. GC60397 (5Z,2E)-CU-3 A DGK-α inhibitor
  16. GC60398 (6R)-FR054

    (3AR,7AR)-5-(乙酰氧基甲基)-2-甲基-5,6,7,7A-四氢-3AH-吡喃并[3,2-D]噁唑-6,7-叉基二醋酸盐

     (6R)-FR054是FR054的一个活性异构体。FR054是HBP酶PGM3的抑制剂，具有显著的抗乳腺癌活性。FR054可诱导内质网应激和ROS依赖的细胞凋亡。
  17. GC41698 (D)2-Rh 110 (trifluoroacetate salt)

    D2R, (Asp)2-Rhodamine 110, Rhodamine 110 bis-(L-aspartic acid amide)

     A fluorogenic caspase substrate
  18. GA20156 (D-Ser(tBu)⁶,Azagly¹⁰)-LHRH (free base)

    戈舍瑞林; ICI 118630
  19. GC61437 (E)-Methyl 4-coumarate

    4-羟基肉桂酸甲酯; Methyl trans-p-coumarate

     A phenol with diverse biological activities
  20. GC72216 (Gly14)-Humanin (human) (acetate) (Gly14)-Humanin (human) (acetate)是Humanin的类似物，其中第14个氨基酸丝氨酸被甘氨酸（Gly）取代。
  21. GC39281 (R)-CR8 trihydrochloride

    CR8, (R)-Isomer trihydrochloride

     An inhibitor of cyclin-dependent kinases
  22. GC60407 (R)-Verapamil D7 hydrochloride

    (R)-(+)-Verapamil D7 hydrochloride

     (R)-VerapamilD7hydrochloride((R)-(+)-VerapamilD7hydrochloride)是(R)-Verapamilhydrochloride的一种氘代化合物。(R)-Verapamilhydrochloride((R)-(+)-Verapamilhydrochloride)是一种P-糖蛋白抑制剂。(R)-Verapamilhydrochloride抑制MRP1介导的转运，导致MRP1过表达细胞对抗癌药产生化学敏感性。
  23. GC60408 (R)-Verapamil hydrochloride

    R-维拉帕米,(R)-(+)-Verapamil hydrochloride

     (R)-Verapamilhydrochloride((R)-(+)-Verapamilhydrochloride)是一种P-糖蛋白(P-Glycoprotein)抑制剂。(R)-Verapamilhydrochloride抑制MRP1介导的转运，导致MRP1过表达细胞对抗癌药产生化学敏感性。
  24. GC62528 (Rac)-Hesperetin

    3′,5,7-三羟基-4-甲氧基黄酮

     (Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质，为有效的，广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。
  25. GC61750 (Rac)-Indoximod

    1-甲基-色氨酸,1-Methyl-DL-tryptophan; (Rac)-NLG-8189

     (Rac)-Indoximod(1-Methyl-DL-tryptophan)是吲哚胺-2,3-双加氧酶(IDO)抑制剂。(Rac)-Indoximod和IFN-γ联用显著降低了表达α-SMA的人心肌成纤维细胞活性，并通过上调IRF-1，Fas和FasL基因诱导凋亡(apoptosis)。
  26. GC52192 (S)-4'-nitro-Blebbistatin

    (-)-4'-nitro-Blebbistatin, p-nitro-Blebbistatin, para-nitro-Blebbistatin

     A more stable and less phototoxic form of (–)-blebbistatin
  27. GC60425 (S)-Verapamil D7 hydrochloride

    (S)-(-)-Verapamil D7 hydrochloride

     (S)-VerapamilD7hydrochloride((S)-(-)-VerapamilD7hydrochloride)是(S)-Verapamilhydrochloride的一种氘代化合物。(S)-Verapamilhydrochloride(S(-)-Verapamilhydrochloride)通过MRP1抑制白三烯C4(LTC4)和钙黄绿素的转运。(S)-Verapamilhydrochloride导致潜在耐药性肿瘤细胞死亡。
  28. GC60008 (S)-Verapamil hydrochloride

    S-维拉帕米,(S)-(-)-Verapamil hydrochloride

     (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) 通过 MRP1 抑制白三烯 C4 (LTC4) 和钙黄绿素的转运。(S)-Verapamil hydrochloride 导致潜在耐药性肿瘤细胞死亡。
  29. GC40121 (Z-DEVD)2-Rh 110 (trifluoroacetate salt)

    (Z-Asp-Glu-Val-Asp)2-Rhodamine 110

     A fluorogenic substrate for caspase-3
  30. GC41742 (Z-IETD)2-Rh 110 (trifluoroacetate salt)

    (Z-Ile-Glu-Thr-Asp)2-R110, Rhodamine 110 bis-(N-CBZ-IETD)2

     A fluorogenic substrate for caspase-8
  31. GC19824 (±)-Pinocembrin

    松属素,(±)-5,7-Dihydroxyflavanone; NSC 43318

     A flavonoid with diverse biological activities
  32. GC19528 1,4-Benzoquinone

    对苯醌

     A toxic metabolite of benzene
  33. GC70375 12-HETE-d8 12-HETE-d8是氘标记的12-HETE。
  34. GC26213 13,14-Dihydro-13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine-14-carbonitrile

    二氢血根碱, DIHYDROSANGUINARINE

  35. GC35057 14-Deoxyandrographolide

    14-去氧穿心莲内酯

     A diterpene lactone with diverse biological properties
  36. GC41938 15-Lipoxygenase Inhibitor 1

    15LO Inhibitor 1

     An inhibitor of 15-LO
  37. GC39296 1G244 1G244 是一种有效的 DPP8/9 抑制剂，IC50 分别为 12 nM 和 84 nM，但不抑制 DPPIV 和 DPPII。1G244 可诱导多发性骨髓瘤细胞凋亡，并具有抗骨髓瘤作用。
  38. GC41612 2'-O-Methylguanosine

    2'-甲氧基鸟苷

     A modified nucleoside
  39. GC19910 2,2',4,4'-Tetrabromodiphenyl Ether

    2,2',4,4'-四溴联苯醚,BDE-47
  40. GC68452 2,4,6-Triiodophenol

    2,4,6-三碘酚

     2,4,6-Triiodophenol 是一种具有口服活性的、强效的 leukotriene B4 (LTB4) 合成抑制剂。2,4,6-Triiodophenol 可诱导小鼠囊胚凋亡。
  41. GC49223 2-deoxy-D-Glucose-13C6

    2-DG-13C6

     An internal standard for the quantification of 2-deoxy-D-glucose
  42. GC62777 2-Methoxy-4-vinylphenol

    4-乙烯基-2-甲氧基苯酚

     2-Methoxy-4-vinylphenol (2M4VP) 是天然的发芽抑制剂，具有抗炎活性。
  43. GC68043 2-tert-Butyl-1,4-benzoquinone 2-tert-Butyl-1,4-benzoquinone 是 butylated hydroxyanisole 的亲电代谢产物，是 2-tert-butylhydroquinone 的氧化产物。
  44. GC48449 28-(Poc-amino)betulin An alkyne derivative of betulin
  45. GC62033 3α-Hydroxy pravastatin sodium

    3Α-羟基普伐他汀钠

     A metabolite of pravastatin
  46. GC20020 3,4-Dihydroxyflavone

    3',4'-二羟基黄酮

     A synthetic flavonoid with diverse biological activities
  47. GC64762 3,6-Dihydroxyflavone

    3,6-二羟基黄酮,3,6-DHF

     3,6-Dihydroxyflavone 是一种抗癌剂。3,6-Dihydroxyflavone 剂量和时间依赖性地降低细胞活力并通过激活半胱天冬酶级联、切割聚 (ADP-核糖) 聚合酶 (PARP) 诱导 apoptosis。3,6-Dihydroxyflavone 增加细胞内氧化应激和脂质过氧化。
  48. GC49849 3-Aminosalicylic Acid

    3-氨基水杨酸

     A salicylic acid derivative
  49. GC60507 3-O-Methylgallic acid

    3-O-甲基没食子酸,3,4-Dihydroxy-5-methoxybenzoic acid

     3-O-Methylgallicacid(3,4-Dihydroxy-5-methoxybenzoicacid)是一种花青素代谢产物，具有强大的抗氧化能力。3-O-Methylgallicacid能抑制Caco-2细胞增殖，IC50值为24.1μM。3-O-Methylgallicacid还诱导细胞凋亡(apoptosis)并具有抗癌作用。
  50. GC42401 4-hydroperoxy Cyclophosphamide

    培磷酰胺,4-OOH-CY

     4-hydroperoxy Cyclophosphamide（4-羟基过氧化环磷酰胺），环磷酰胺的活性代谢产物，能够交联DNA并独立于caspase受体激活诱导T细胞凋亡，通过产生活性氧（ROS）激活线粒体死亡途径。
  51. GC60525 4-Vinylphenol (10%w/w in propylene glycol)

    4-乙烯基苯酚

    4-Vinylphenol存在于药用草白花蛇舌草，野生稻中，也是葡萄酒中乳酸菌对对香豆酸和阿魏酸的代谢产物。4-Vinylphenol诱导凋亡(apoptosis)，在体内抑制血管形成并抑制浸润性乳腺肿瘤生长。

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