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Home >> Signaling Pathways >> Immunology/Inflammation >> Apoptosis

Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Products for  Apoptosis

  1. Cat.No. 产品名称 Information
  2. GC48493 PCI 45227

    依鲁替尼代谢物,PCI-45227

     An active metabolite of ibrutinib
  3. GC50045 PD 166285 dihydrochloride

    6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐

     A tyrosine kinase inhibitor
  4. GC62125 PD-1/PD-L1-IN-10 PD-1/PD-L1-IN-10 (compound B2) 是具有口服活性的 PD-1/PD-L1 抑制剂 (IC50 of 2.7 nM)，具有抗肿瘤活性。
  5. GC91688 PDIC-NN PDIC-NN is an intermediate in the synthesis of PDIC-NS , an activator of stimulator of interferon genes (STING) with anticancer activity.
  6. GC91820 PDIC-NS PDIC-NS is an activator of stimulator of interferon genes (STING).
  7. GC70753 PDK4-IN-1 PDK4-IN-1是一种蒽醌衍生物和一种强效的口服活性丙酮酸脱氢酶激酶4（PDK4）抑制剂，IC50值为84nM。
  8. GC39500 PDK4-IN-1 hydrochloride PDK4-IN-1 hydrochloride 是一种蒽醌衍生物，也是一种有效的，口服活性的丙酮酸脱氢酶激酶 4 (PDK4) 抑制剂，IC50 值为 84 nM。PDK4-IN-1 hydrochloride 有效抑制细胞转化和细胞增殖并诱导细胞凋亡 (apoptosis)。PDK4-IN-1 hydrochloride 具有抗糖尿病，抗癌和抗过敏作用。
  9. GC70298 Peginterferon beta-1a Peginterferon β-1a是第一个聚乙二醇化的干扰素β -1a分子。
  10. GC62505 Pelcitoclax

    APG-1252

     Pelcitoclax (APG-1252) 是一种有效的 Bcl-2/Bcl-xl 抑制剂，具有抗肿瘤和促凋亡作用。
  11. GC60283 Pentagamavunon-1

    PGV-1

     Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物，具有口服活性，通过多个机制诱导凋亡信号，如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。
  12. GC90582 Perfluorooctanesulfonic Acid

    Heptadecafluorooctanesulfonic Acid, Perfluorooctane sulfonate, Perfluorooctylsulfonic Acid, PFOS

    一种全氟烷基物质
  13. GC50253 PF 543 hydrochloride

    Sphingosine Kinase 1 Inhibitor II hydrochloride

     A potent inhibitor of SPHK1
  14. GC72001 Phellamurin Phellamurin是从黄柏叶中提取的一种植物黄酮类苷，具有抑制肠道p -糖蛋白的作用。
  15. GC61179 Phenazine methylsulfate

    吩嗪硫酸甲酯; 5-Methylphenazinium methylsulfate

     A free radical generator
  16. GC49015 Phenethyl isothiocyanate

    2-苯基乙基异硫代氰酸酯

     An isothiocyanate with anticancer activity
  17. GC18522 Phosphatidylserines (sodium salt)

    L-α-磷脂酰丝氨酸（钠盐）,L-α-Phosphatidylserine

     A mixture of phosphatidylserines isolated from soy
  18. GC49084 PHY34 An inhibitor of late-stage autophagy
  19. GC69705 Physalin A Physalin A 是一种从 Physalis alkekengi var franchetii 中分离出来的 withanolide。 Physalin A 诱导细胞凋亡 (apoptosis) 与 caspase-3 和 caspase-8 表达上调相关的。Physalin A 诱导自噬，发现可拮抗 HT1080 细胞的凋亡。Physalin A具有研究癌症疾病的潜力。
  20. GC61183 Physalin B

    酸浆苦味B

     PhysalinB是Capegooseberry中主要的甾体活性成分之一，通过调节p53依赖的凋亡途径，诱导乳腺癌细胞周期阻滞和诱导凋亡(apoptosis)。PhysalinB抑制人结肠癌细胞泛素-蛋白酶体通路并诱导不完全自噬反应。
  21. GC61184 Physalin F

    酸浆苦味素F

     PhysalinF是一种具有强烈抗炎和免疫调节作用的分泌型甾体。PhysalinF诱导人外周血单个核细胞凋亡，降低人T淋巴细胞1型病毒(HTLV-1)感染后的自发增殖和细胞因子的产生。
  22. GC44640 Phytosphingosine

    植物鞘氨醇

     A sphingolipid
  23. GC60288 Picrocrocin

    苦番紅花素

     Picrocrocin, the chemical most responsible for the bitter taste of saffron, is isolated from saffron and inhibits proliferation of cancer cells.
  24. GC45549 Pitstop2 Pitstop2是一种网格蛋白抑制剂，可抑制网格蛋白末端结构域的两性结合，IC50值为12μM。
  25. GC61995 PKCβ inhibitor 1

    3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮

     A PKCβ Inhibitor
  26. GC62111 PND-1186 hydrochloride

    VS-4718 hydrochloride; SR-2516 hydrochloride

     A potent FAK inhibitor
  27. GC45550 Pogostone

    广藿香酮

     A pyranone with antifungal and insecticidal activities
  28. GC60297 Polyinosinic-polycytidylic acid sodium

    双链聚肌胞; Poly(I:C)

     Polyinosinic-polycytidylic acid sodium (Poly I:C)是一种合成的dsRNA,可以模拟病毒感染,并通过触发特定的模式识别受体(PRRs),如toll样受体3(TLR3)和维甲酸诱导基因I(RIG-I)样受体,包括RIG-I和黑色素瘤分化相关基因5,引发宿主免疫反应。
  29. GC39041 Polyporenic acid C

    聚孔酸C

     Polyporenic acid C 是从 P. cocos 中分离出的羊毛甾烷型三萜。Polyporenic acid C 通过死亡受体介导的凋亡途径诱导细胞凋亡 (apoptosis)，而无需线粒体的参与。 Polyporenic acid C 是治疗肺癌的有前途的药物。
  30. GC62487 POMHEX POMHEX 是一个消旋混合物，是具有细胞渗透性的 HEX 的 POM 前体药物，是ENO2 的特异性抑制剂。POMHEX 对ENO1 缺失的细胞表现出低纳摩尔级别活性，并对 ENO1 缺失的肿瘤模型表现出良好的抗癌效果。POMHEX 是有效的糖酵解抑制剂。
  31. GC62483 Pomolic acid

    坡模酸,Randialic acid A

     Pomolic acid is a pentacyclic triterpene isolated from Euscaphis japonica, and is highly effective in inhibiting cell growth and induces apoptosis.
  32. GC52104 Ponatinib (hydrochloride)

    泊那替尼盐酸盐,AP24534 hydrochloride

     An inhibitor of native and mutant Bcr-Abl
  33. GC39069 Poncirin

    枸橘甙

     A flavonoid glycoside with diverse biological activities
  34. GC61203 Ponicidin

    冬凌草乙素,Rubescensine B

     Ponicidin(RubescensineB)是源于冬凌草的二萜，具有免疫调节、抗炎、抗病毒和抗癌作用。Ponicidin(RubescensineB)可诱导胃癌细胞凋亡(apoptosis)，降低JAK2和STAT3的磷酸化水平，单对其蛋白水平无作用。
  35. GC61945 PR-924 PR-924 是一种选择性三肽环氧酮免疫蛋白酶亚单位 LMP-7 的抑制剂，IC50 为 22 nM。PR-924 共价修饰蛋白酶体的 N 端苏氨酸活性位点。PR-924 在多发性骨髓瘤细胞中抑制细胞生长并触发凋亡 (apoptosis)，并具有抗肿瘤活性。
  36. GC71622 Prednisone-d8 Prednisone-d8是氘标记的泼尼松。
  37. GC65066 Prodigiosin hydrochloride

    PRODIGIOSIN盐酸盐,Prodigiosine hydrochloride

     A natural red pigment and antibiotic
  38. GC39063 Prosapogenin A

    重楼皂苷E,Progenin III

     Prosapogenin A 是藜芦中的天然产物，通过抑制 STAT3 信号通路和糖酵解，在体外诱导人癌细胞凋亡。
  39. GC65555 PROTAC FLT-3 degrader 1 PROTAC FLT-3 degrader 1 是基于 von Hippel-Lindau 的 FLT-3内部串联重复 (ITD) 降解剂 PROTAC，IC50为0.6 nM。抗增殖，诱导凋亡活性。
  40. GC63916 PROTAC-O4I2 PROTAC-O4I2 是一种靶向剪接因子 3B1 (SF3B1) 的 PROTAC。PROTAC-O4I2 在 K562 细胞中诱导 FLAG-SF3B1 降解，IC50 值为 0.244 μM。PROTAC-O4I2 还诱导 K562 WT 细胞凋亡 (apoptosis)。
  41. GC48406 PSI (trifluoroacetate salt)

    Proteasome Inhibitor I, Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde, Z-Ile-Glu(OtBu)-Ala-Leu-CHO

     A proteasome inhibitor
  42. GC61224 Pyrazoloacridine

    NSC366140无结构图,NSC 366140; PD 115934

     Pyrazoloacridine(NSC366140)具有抗癌活性，抑制拓扑异构酶1和2的活性(topoisomerases1and2)。Pyrazoloacridine(NSC366140)对K562髓系白血病细胞中的IC50值为1.25μM(24h)。
  43. GC49221 QLT0267 An ILK inhibitor
  44. GC62411 QTX125 QTX125 是一种有效且高度选择性的 HDAC6 抑制剂。与其他 HDAC 相比，QTX125 对 HDAC6 具有出色的选择性。QTX125 具有抗肿瘤作用。
  45. GC61227 Quercetin D5

    槲皮素 d5

     QuercetinD5是Quercetin的一种氘代化合物。Quercetin是一种天然黄酮类化合物，可激活或抑制许多蛋白质的活性。Quercetin可激活SIRT1，也可抑制PI3K，抑制PI3Kγ，PI3Kδ，PI3Kβ的IC50分别为2.4μM,3.0μM,5.4μM。
  46. GC48020 Quercetin-d3 (hydrate) A neuropeptide with diverse biological activities
  47. GC72359 Quilizumab Quilizumab（抗人NGcGM3重组抗体）是一种人源化IgG1κ单克隆抗体。
  48. GC61229 Quinacrine dihydrochloride

    阿的平; Mepacrine dihydrochloride; SN-390 dihydrochloride

     Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.
  49. GC19936 Quisinostat dihydrochloride

    QUISINOSTAT二盐酸盐,JNJ-26481585 dihydrochloride

     A pan-HDAC inhibitor
  50. GC60317 RA-9

    (3E,5E)-3,5-双(4-硝基亚苄基)哌啶-4-酮

     RA-9 is a cell-permeable, potent and selective inhibitor of proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.
  51. GC62399 RA375 RA375 是 RPN13 (26S 蛋白酶体亚基) 抑制剂。RA375 激活 UPR 信号、ROS 产生和凋亡。RA375 的抗肿瘤活性是 RA190的 10 倍。

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