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Home >> Signaling Pathways >> Immunology/Inflammation >> Apoptosis

Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Products for  Apoptosis

  1. Cat.No. 产品名称 Information
  2. GC73990 SDU-071 SDU-071是BRD4-p53抑制剂的强效口服活性抑制剂。
  3. GC60336 SEC SEC通过AMPK/mTORC1/STAT3信号通路诱导ANXA7GTPase的激活。SEC选择性的促进癌细胞的凋亡，诱导ITGB4核转位，表达高水平ITGB4。
  4. GC74007 SelSA SelSA是一种选择性的口服活性组蛋白去乙酰化酶6 （HDAC6）抑制剂，IC50为56.9 nM。
  5. GC74476 Seribantumab

    瑟瑞妥单抗; SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant Antibody

     Seribantumab (MM 121)是一种靶向HER3的全人源IgG2单克隆抗体。
  6. GC73188 SFI003 SFI003是一种SRSF3抑制剂，通过SRSF3/DHCR24/ROS轴驱动CRC细胞凋亡，在体外和体内均表现出强大的抗肿瘤作用。
  7. GC73129 SIAIS164018 hydrochloride SIAIS164018 hydrochloride是一种基于protac的ALK和EGFR降解剂，ALK和ALK G1202R的IC50值分别为2.5 nM和6.6 nM。
  8. GC62242 Sideroxylin Sideroxylin 是一种从 Callistemon lanceolatus 中分离的 C-甲基化黄酮，对金黄色葡萄球菌具有抗菌活性。Sideroxylin 可抑制卵巢癌细胞增殖并诱导凋亡 (apoptosis)，导致 DNA 断裂，线粒体膜去极化，产生活性氧 (ROS)。
  9. GC41533 Silybin

    水飞蓟宾

     Hepatoprotective flavonoid and 5-LO inhibitor
  10. GC49431 Simazine

    西马嗪；西玛津

     A triazine herbicide
  11. GC49425 Simazine-d10

    十氘代西玛嗪

     An internal standard for the quantification of simazine
  12. GC69899 SIRT6 activator 12q SIRT6 activator 12q 是有效的、选择性的和具有口服活性的 SIRT6 激活剂，对 SIRT1、SIRT2、SIRT3、SIRT5、SIRT6 的 IC50 值分别为 171.20、>200、>200、>200、0.58 μM。SIRT6 activator 12q 抑制细胞生长和迁移。SIRT6 activator 12q 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 G2 期。SIRT6 activator 12q 显示出抗癌活性。
  13. GC44896 SKI 178 A non-selective inhibitor of SPHK1 and SPHK2
  14. GC60339 SKI V

    2-(3,4-二羟基亚苄基)苯并呋喃-3(2H)-酮

     SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
  15. GC69912 SLC7A11-IN-1 SLC7A11-IN-1 是一种有效的SLC7A11 抑制剂。SLC7A11-IN-1 显示出抗增殖活性。SLC7A11-IN-1 抑制细胞侵袭和转移。SLC7A11-IN-1 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 S 期。SLC7A11-IN-1 具有抗肿瘤活性。
  16. GC46222 SLM6031434 (hydrochloride) An SPHK2 inhibitor
  17. GC19522 Sodium oleate

    油酸钠,cis-9-Octadecenoic acid sodium salt, Oleic acid sodium salt

    A monounsaturated fatty acid
  18. GC64223 Sophocarpine monohydrate

    槐果碱水合物

     An alkaloid with diverse biological activities
  19. GC38970 Sophoraflavanone G

    槐黄烷酮G,Kushenol F

     A flavonoid with diverse biological activities
  20. GC74538 Sotevtamab

    索泰妥单抗; 16B5; AB-16B5

     Sotevtamab (16B5)是一种人源IgG2抗聚簇素单克隆抗体（mAb）。
  21. GC63604 Sparfosic acid Sparfosic acid 是 DNA 抗代谢剂和天门冬氨酸氨甲酰转移酶 (aspartate transcarbamoyl transferase) 的有效抑制剂。Sparfosic acid 具有抗肿瘤活性。天冬氨酸氨甲酰转移酶催化第二步 de novo 嘧啶生物合成。
  22. GC74042 SpiD3 SpiD3是一种新型的螺环二聚体。
  23. GC64946 SRT 2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
  24. GC91228 SSE1806

    一种微管不稳定剂
  25. GC63202 SSK1 SSK1，是一种衰老特异性杀伤化合物，是一种 β-galactosidase 靶向前药，可减轻炎症。SSK1 被溶酶体 β-galactosidase 激活，并通过激活 p38 MAPK 和诱导细胞凋亡 (apoptosis) 选择性杀死衰老细胞。
  26. GC31631 Stachyose tetrahydrate

    水苏糖四水合物

    Stachyose is a natural sugar found in many foods like beans and vegetables.
  27. GC52293 STAT3 Inhibitor 4m

    Signal Transducer and Activator of Transcription 3 Inhibitor 4m

     A STAT3 inhibitor
  28. GC73311 STAT3-IN-13 STAT3-IN-13（化合物6f）是一种有效的STAT3抑制剂。
  29. GC73355 STAT3-SH2 domain inhibitor 1 STAT3-SH2 domain inhibitor 1是STAT3（STAT3-SH2结构域）的强效Src同源2（SH2）结构域抑制剂，Kd值为1.57μM。
  30. GC65344 STAT5-IN-2 STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells.
  31. GC65249 STL127705 STL127705 (Compound L) 是一种有效的 Ku 70/80 异二聚体蛋白 Ku 70/80 heterodimer protein 抑制剂，IC50 为 3.5 μM。STL127705 通过抑制 DNA-PKCS 激酶的激活干扰 Ku70/80 与 DNA 的结合。STL127705 显示出抗增殖和抗肿瘤活性。 STL127705 诱导细胞凋亡 (apoptosis) 。
  32. GC73697 STM3006 STM3006是一种高效、选择性和口服活性的METTL3抑制剂（IC50:5nM）。
  33. GC48118 Sunitinib-d10

    舒尼替尼-D10,SU 11248-d10

     An internal standard for the quantification of sunitinib
  34. GC60348 Supinoxin

    RX-5902

     Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶 (P-p68) 的强效口服活性抑制剂，并且是一个一流的抗肿瘤试剂 (anti-cancer agent)。Supinoxin 与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。 Supinoxin 诱导细胞凋亡 (apoptosis) 并抑制 TNBC 癌细胞系的生长，IC50 的范围为 10 nM 至 20 nM。
  35. GC61492 SW106065

    N-(吡啶-3-基)噻吩-2-羧酰胺

     SW-106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST), which can inhibit ATP consumption of sporadic MPNST and other models of MPNST with an EC50 of 1 ?M.
  36. GC73795 T-1-PMPA T-1-PMPA是一种具有凋亡特性的强效EGFR抑制剂。
  37. GC65395 T025 T025 是口服有效的Cdc2-like 激酶 (CLK) 抑制剂，对 CLK1，CLK2，CLK3，CLK4，DYRK1A，DYRK1B 和 DYRK2 的 Kd 分别为4.8，0.096，6.5，0.61，0.074，1.5 和 32 nM。T025 诱导 caspase-3/7 介导的细胞凋亡 (apoptosis)。T025 可降低 CLK 依赖性磷酸化。T025 在血液和实体癌细胞系中均具有抗增殖活性 (IC50值:30-300 nM)。T025 具有抗肿瘤功效，主要用于MYC驱动的疾病研究。
  38. GC65433 Tafasitamab

    XmAb5574; MOR00208; Tafasitamab-cxix

     Tafasitamab (XmAb5574) 是一种 Fc 修饰的人源化单克隆抗体，可与人 B 细胞表面抗原 CD19 结合。
  39. GC61314 Taltobulin hydrochloride

    HTI-286 hydrochloride; SPA-110 hydrochloride

     Taltobulinhydrochloride(HTI-286hydrochloride)是一种合成的三肽半胱氨酸类似物，Taltobulin是一种有效的抗微管剂(antimicrotubule)，可在体内外规避P-糖蛋白介导的耐药性。Taltobulinhydrochloride抑制纯化的微管蛋白聚合，破坏细胞中的微管组织，并诱导有丝分裂停滞以及凋亡(apoptosis)。
  40. GC48124 Tamoxifen-d5

    ICI 47699-?d5; (Z)-Tamoxifen-?d5; trans-Tamoxifen-?d5

     An internal standard for the quantification of tamoxifen
  41. GC71915 Tanshinone IIB Tanshinone IIB是丹参的主要活性成分，在亚洲国家被广泛用于中风和冠心病的研究。
  42. GC60352 Taraxerol

    蒲公英萜醇

     Taraxerol 具有抗炎和抗癌作用。
  43. GC39040 Taraxerol acetate

    醋酸蒲公英霜

     Taraxerol acetate 是 COX-1 和 COX-2 抑制剂， IC50 值分别为 116.3 μM 和 94.7μM。Taraxerol acetate 具有抗癌作用并诱导细胞凋亡(apoptosis)。
  44. GC62630 TAS-117 hydrochloride

    TAS-117 hydrochloride

     TAS-117 hydrochloride 是一种有效、选择性、具有口服活性的别构 Akt 抑制剂 (对 Akt1、2 和 3 的 IC50 分别为 4.8、1.6 和 44 nM)。TAS-117 hydrochloride 激发抗骨髓瘤活性并增强蛋白酶体抑制诱导的致命内质网应激。TAS-117 hydrochloride 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。
  45. GC44992 Taurochenodeoxycholic Acid (sodium salt)

    牛磺鹅去氧胆酸钠盐; 12-Deoxycholyltaurine sodium

     A taurine-conjugated form of chenodeoxycholic acid
  46. GC62191 TD52 A derivative of erlotinib
  47. GC64936 TD52 dihydrochloride A derivative of erlotinib
  48. GC39450 Tea polyphenol

    茶多酚

     Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.
  49. GC48135 Tebufenozide

    虫酰肼

     An insecticide and ecdysone receptor agonist
  50. GC18458 Terrein

    土曲霉酮

     A fungal metabolite with diverse biological activities
  51. GC61665 Tetrahydroxyquinone monohydrate

    四羟基苯醌水合物,Tetrahydroxy-1,4-benzoquinone monohydrate; Tetrahydroxybenzoquinone monohydrate

     A redox-active hydroxyquinone

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