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Home >> Signaling Pathways >> Immunology/Inflammation >> Apoptosis

Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Products for  Apoptosis

  1. Cat.No. 产品名称 Information
  2. GC71507 5'-Methylthioadenosine-13C6 5'-Methylthioadenosine-13C6是13C标记的5'-甲硫腺苷。
  3. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone

    (±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL

     An active metabolite of various polyphenols
  4. GC90889 5-(3'-Hydroxyphenyl)-γ-Valerolactone

    δ-(3'-Hydroxyphenyl)-γ-Valerolactone, 5-(3'-Hydroxyphenyl)-γ-VL, δ-(3'-Hydroxyphenyl)-γ-VL, (3'-hydroxy)-PVL

    多种多酚的代谢产物。
  5. GC68562 5-Aminolevulinic acid-13C-1 hydrochloride

    5-ALA-13C-1 hydrochloride; δ-Aminolevulinic acid-13C-1 hydrochloride; 5-Amino-4-oxopentanoic acid-13C-1 hydrochloride

     5-Aminolevulinic acid-13C-1 (5-ALA-13C-1) hydrochloride 是 13C 标记的 5-Aminolevulinic acid hydrochloride。5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) 是体内血红素生物合成的中间体，为四吡咯的前体。
  6. GC71833 5-Aminolevulinic acid-d2 hydrochloride 5-Aminolevulinic acid-d2 hydrochloride是氘标记的5-氨基酮戊酸盐酸盐。
  7. GC63958 6α-Hydroxy Paclitaxel-d5

    紫杉醇杂质

     6α-Hydroxy Paclitaxel-d5 是 6α-Hydroxy paclitaxel 的氘代物。6α-Hydroxy paclitaxel 是紫杉醇的初级代谢物。6α-Hydroxy paclitaxel 对有机阴离子转运多肽 1B1/SLCO1B1 (OATP1B1) 具有与紫杉醇相似的时间依赖性抑制效力，但它对 OATP1B3 不具有时间依赖性作用。6α-Hydroxy paclitaxel 可用于癌症研究。
  8. GC49429 6-keto Lithocholic Acid

    3Α-羟基-6K-5Β-胆甾烷-24-酸

     A metabolite of lithocholic acid
  9. GC45673 7,8-Dihydroneopterin

    7,8-二氢-D-新蝶呤

     An antioxidant
  10. GC70659 9-cis-Retinoic acid-d5 9-cis-Retinoic acid-d5是氘标记的9-顺式维甲酸。
  11. GC60544 A-192621 A-192621是一种有效的非肽，口服活性，选择性内皮素B(ETB)受体拮抗剂，IC50为4.5nM，Ki为8.8nM。A-192621的选择性比ETA高636倍(IC50为4280nM，Ki为5600nM)。A-192621促进PASMC细胞凋亡，并引起动脉血压升高和血浆ET-1水平升高。
  12. GC42677 ABO (hydrochloride) A modulator of annexin A7
  13. GC60548 ABT-100 ABT-100是一种有效的，高选择性和口服活性的farnesyltransferase抑制剂。ABT-100抑制细胞增殖(对于EJ-1，DLD-1，MDA-MB-231，HCT-116，MiaPaCa-2，PC-3和DU-145细胞的IC50分别为2.2nM，3.8nM，5.9nM，6.9nM，9.2nM，70nM和818nM)，可增加细胞凋亡并减少血管生成。ABT-100具有广谱抗肿瘤活性。
  14. GC49745 ABT-263-d8

    生根粉263 d8

     An internal standard for the quantification of ABT-263
  15. GC70733 ABT-510 acetate ABT-510 acetate是一种抗血管生成TSP肽（血小板反应蛋白-1类似物），在上皮性卵巢癌症原位同基因模型中诱导细胞凋亡并抑制卵巢肿瘤生长。
  16. GC90489 AC 187 (trifluoroacetate salt)

    Acetyl-(Asn30,Tyr32)-Calcitonin8-32, Acetyl-Asn30,Tyr32Salmon Calcitonin (8 -37), Acetyl-Asn30,Tyr32 sCT(8 -37)

    一种钙降素和淀粉样蛋白受体的拮抗剂。
  17. GC40122 Ac-AAVALLPAVLLALLAP-DEVD-CHO (trifluoroacetate salt)

    Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO, Ac-AAVALLPAVLLALLAP-DEVD-aldehyde, Ac-AAVALLPAVLLALLAPDEVD-CHO, Caspase-3 Inhibitor I, DEVD-CHO-CPP 32

     A caspase-3 inhibitor
  18. GC40118 Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt)

    Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO, Caspase-8 Inhibitor I

     An inhibitor of caspase-8 and granzyme B
  19. GC40123 Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt)

    Caspase Inhibitor II, Ac-AAVALLPAVLLALLAP-VAD-aldehyde, Ac-AAVALLPAVLLALLAPVAD-CHO

     A non-selective caspase inhibitor
  20. GC48470 Ac-DEVD-CHO (trifluoroacetate salt)

    N-Ac-Asp-Glu-Val-Asp-CHO

     A dual caspase-3/caspase-7 inhibitor
  21. GC48430 Ac-DEVD-CMK (trifluoroacetate salt)

    AcAspGluValAspCMK, Caspase3 Inhibitor III

     An inhibitor of caspase-3
  22. GC42687 Ac-DMQD-AMC (trifluoroacetate salt)

    Ac-Asp-Met-Gln-Asp-AMC, Ac-Asp-Met-Gln-Asp-7-amino-4-methylcoumarin

     A fluorogenic substrate for caspase-3
  23. GC42688 Ac-DMQD-CHO (trifluoroacetate salt)

    Ac-Asp-Met-Gln-Asp-CHO, Caspase-3 Inhibitor

     An inhibitor of caspase-3
  24. GC40154 Ac-ESMD-CHO (trifluoroacetate salt)

    Ac-Glu-Ser-Met-Asp-CHO

     An inhibitor of caspase-3 maturation
  25. GC40152 Ac-IEPD-pNA (trifluoroacetate salt)

    Ac-Ile-Glu-Pro-Asp-p-nitroanilide, Caspase-8 Chromogenic Substrate, Granzyme B Substrate VIII

     A colorimetric granzyme B and caspase-8 substrate
  26. GC40164 Ac-IETD-CHO (trifluoroacetate salt)

    Caspase-8 Inhibitor

     A caspase-8 inhibitor
  27. GC42708 Ac-LEHD-AFC (trifluoroacetate salt)

    N-Acetyl-Leu-Glu-His-Asp-7-amino-4-Trifluoromethylcoumarin, Caspase-9 substrate (Fluorogenic)

     A caspase-4, -5, and -9 fluorogenic substrate
  28. GC18226 Ac-LEHD-AMC (trifluoroacetate salt)

    Ac-Leu-Glu-His-Asp-AMC, Caspase-9 Substrate

     A caspase-9 fluorogenic substrate
  29. GC46791 Ac-LEHD-pNA (trifluoroacetate salt)

    Ac-Leu-Glu-His-Asp-pNA, Caspase-9 Chromogenic Substrate I

     A neuropeptide with diverse biological activities
  30. GC42709 Ac-LEVD-CHO (trifluoroacetate salt)

    Ac-Leu-Glu-Val-Asp-CHO, Caspase-4 Inhibitor I

     A caspase-4 inhibitor
  31. GC13400 Ac-VDVAD-AFC

    N-Acetyl-Val-Asp-Val-Ala-Asp-7-amino-4-Trifluoromethylcoumarin Caspase-2 Substrate (Fluorogenic)

     A fluorogenic substrate for caspase-2
  32. GC52372 Ac-VDVAD-AFC (trifluoroacetate salt)

    N-Acetyl-Val-Asp-Val-Ala-Asp-AFC, N-Acetyl-Val-Asp-Val-Ala-Asp-7-amino-4-Trifluoromethylcoumarin, Caspase-2 Substrate (Fluorogenic)

     A fluorogenic substrate for caspase-2
  33. GC42716 Ac-VDVAD-pNA (trifluoroacetate salt)

    Ac-Val-Asp-Val-Ala-Asp-pNA, Caspase-2 Chromogenic Substrate, acetyl-Val-Asp-Val-Ala-Asp-p-nitroanilide, acetyl-VDVAD-p-nitroanilide

     A colorimetric caspase-2 substrate
  34. GC48974 Ac-VEID-AMC (ammonium acetate salt)

    NAcetylValGluIleAsp7amido4Methylcoumarin, Caspase6 Substrate (Fluorogenic)

     A caspase-6 fluorogenic substrate
  35. GC42718 Ac-VEID-CHO (trifluoroacetate salt)

    Ac-Val-Glu-Ile-Asp-CHO

     A caspase-6 inhibitor
  36. GC40162 Ac-VEID-pNA (trifluoroacetate salt)

    Ac-Val-Glu-Ile-Asp-pNA, Ac-Val-Glu-Ile-Asp-p-nitroanilide, Caspase-6 Chromogenic Substrate

     A colorimetric caspase-6 substrate
  37. GC70584 Actinomycin X2 Actinomycin X2（放线菌素V），由许多链霉菌属产生。
  38. GC39584 AGN194204

    IRX4204; NRX194204; VTP 194204

     AGN194204 (IRX4204) 是一种具有口服活性的，选择性 RXR 激动剂，对 RXRα，RXRβ 和 RXRγ 的 Kd 值分别为 0.4 nM，3.6 nM 和 3.8 nM，EC50 分别为 0.2 nM，0.8 nM 和 0.08 nM。AGN194204 对 RAR 无活性，并具有抗炎和抗癌作用。
  39. GC68632 AK-778-XXMU AK-778-XXMU是DNA结合2 (ID2) 拮抗剂的有效抑制剂，KD为129 nM。AK-778-XXMU 能抑制胶质瘤细胞株的迁移和侵袭，诱导细胞凋亡 (apoptosis)，更重要的是能减缓肿瘤生长。
  40. GC19897 Albendazole Sulfone

    阿苯达唑砜

     An active metabolite of albendazole
  41. GC49773 Albendazole sulfone-d3

    阿苯哒唑砜-D3

     An internal standard for the quantification of albendazole sulfone
  42. GC48848 Albendazole-d7

    阿苯达唑-D7,SKF-62979-d7

     An internal standard for the quantification of albendazole
  43. GC40094 all-trans Retinoic Acid-d5

    atRA-d5, RA-d5, Vitamin A Acid-d5

     An internal standard for the quantification of all-trans retinoic acid
  44. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid
  45. GC18437 Alternariol monomethyl ether

    交链孢霉甲基醚

     A mycotoxin
  46. GC63932 Amsilarotene

    4-[[3,5-二(三甲基硅烷基)苯甲酰基]氨基]苯甲酸,TAC-101; Am 555S

     Amsilarotene (TAC-101; Am 555S) 是一种具有口服活性的合成类视黄醇，对视黄酸受体 α (RAR-α) 具有选择性亲和力，对 RAR-α 和 RAR-β 的 Ki 值为 2.4 nM 和 400 nM。Amsilarotene 诱导人胃癌、肝细胞癌和卵巢癌细胞的凋亡 (apoptotic)。Amsilarotene 可用于癌症研究。
  47. GC60584 Angiotensin II human acetate

    血管紧张素II,Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate

     A peptide hormone
  48. GC49259 Antagonist G (trifluoroacetate salt)

    Arg-D-Trp-NmePhe-D-Trp-Leu-Met-NH2, Arg6,D-Trp7,9,NmePhe8-substance P (6-11)

     A neuropeptide antagonist
  49. GC91176 AOH1996

    一种PCNA抑制剂
  50. GC62640 APG-1387 APG-1387 是一种二价 SMAC 模拟物，是 IAP 拮抗剂，可阻断 IAP 家族蛋白 (XIAP，cIAP-1，cIAP-2 和 ML-IAP) 的活性。APG-1387 诱导 cIAP-1 和 XIAP 蛋白降解以及 caspase-3 激活和 PARP 裂解，从而导致细胞凋亡。APG-1387 可用于肝细胞癌，卵巢癌和鼻咽癌的研究。
  51. GC42827 Apoptolidin

    Apoptolidin A

     An apoptosis inducer and F1FO ATPase inhibitor

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