Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Products for Apoptosis

Cat.No. 产品名称 Information
GC73309 Anti-melanoma agent 1 Anti-melanoma agent 1（化合物5m）是一种抗黑色素瘤药物，可诱导细胞凋亡。
GC91176 AOH1996
一种PCNA抑制剂
GC62640 APG-1387 APG-1387 是一种二价 SMAC 模拟物，是 IAP 拮抗剂，可阻断 IAP 家族蛋白 (XIAP，cIAP-1，cIAP-2 和 ML-IAP) 的活性。APG-1387 诱导 cIAP-1 和 XIAP 蛋白降解以及 caspase-3 激活和 PARP 裂解，从而导致细胞凋亡。APG-1387 可用于肝细胞癌，卵巢癌和鼻咽癌的研究。
GC74102 Apomine
SR-45023A; SR 9223i; SK&F-99085
Apomine (SR-45023A)是一种抑制胆固醇合成中甲羟戊酸/类异戊二烯途径的抗肿瘤药物。
GC42827 Apoptolidin
Apoptolidin A
An apoptosis inducer and F₁F_O ATPase inhibitor
GC65004 Apostatin-1
Apt-1
Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apostatin-1 inhibits bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM.
GC70759 AQX-435 AQX-435是一种强效的SHIP1磷酸酶激活剂。
GC40116 Aranorosin A fungal metabolite
GC65163 Ardisiacrispin B
百两金皂苷B
Ardisiacrispin B在多因素耐药癌细胞中显示细胞毒性作用，通过铁中毒和凋亡细胞死亡。
GC49314 Arecaidine propargyl ester (hydrobromide)
1,2,5,6-四氢-1-甲基-3-吡啶羧酸2-丙炔-1-基酯氢溴酸盐
A muscarinic M₂ agonist
GC73077 ARI-1 ARI-1是受体酪氨酸激酶样孤儿受体1 （ROR1）抑制剂的抑制剂。
GC60601 ARRY-382 ARRY-382 is a highly selective, oral inhibitor of the CSF1R with an IC50 of 9 nM.
GC62615 AS-99 AS-99 是一流的、有效的、选择性的 ASH1L 组蛋白甲基转移酶抑制剂（IC50=0.79μ；M，Kd=0.89μ；M），具有抗白血病活性。 AS-99 阻断细胞增殖，诱导细胞凋亡和分化，下调 MLL 融合靶基因，并减少体内白血病负担。
GC40715 Ascochlorin
壳二孢氯素,Ilicicolin D
An isoprenoid antibiotic and antiviral
GC74029 ASCT2-IN-1 ASCT2-IN-1（化合物20k）是一种ASCT2抑制剂，在A549和HEK293细胞中的IC50值分别为5.6 μM和3.5 μM。
GC74030 ASCT2-IN-2 ASCT2-IN-2（化合物25e）是一种ASCT2抑制剂，IC50为5.14μM。
GC62426 ASK1-IN-2 ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM.
GC71258 ASK1-IN-4 ASK1-IN-4（化合物17）是ASK1抑制剂（IC50=0.2μM）。
GC60603 Asperosaponin VI
川续断皂苷 VI
A triterpenoid saponin with diverse biological activities
GC72803 Aspidin BB Aspidin BB是一种间苯三酚衍生物，可从冠毛鳞毛蕨的地上部分分离得到。
GC68700 ASR-488 ASR-488 可激活 mRNA 结合蛋白 CPEB1，诱导细胞凋亡 (apoptosis) 并抑制膀胱癌的生长。
GC62499 ATH686 ATH686 是一种有效的，选择性的，ATP 竞争性的 FLT3 抑制剂。ATH686 靶向突变 FLT3 蛋白激酶活性，并通过诱导凋亡 (apoptosis) 和抑制细胞周期来抑制具有 FLT3 突变的细胞的增殖。ATH686 具有抗白血病作用。
GC73939 ATPase-IN-3 ATPase-IN-3（化合物6）是一种atp酶抑制剂。
GC72319 Atrosab Atrosab是一种人源化IgG1拮抗性抗TNFR1抗体。
GC39699 Aurintricarboxylic acid
金精三羧酸
A protein synthesis inhibitor with diverse biological activities
GC72858 Avenanthramide A Avenanthramide A是一种可以在燕麦（Avena sativa L）。
GC72868 AZA197 AZA197是Cdc42的选择性小分子抑制剂。
GC46901 Azadirachtin
印楝素
A naturally-occurring insecticide
GC48971 AZD 1152 (hydrochloride)
5-[[7-[3-[乙基[2-(磷酰氧基)乙基]氨基]丙氧基]-4-喹唑啉基]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺二盐酸盐
A prodrug for a potent Aurora B inhibitor
GC18566 AZD 3147 A dual mTORC1/mTORC2 inhibitor
GC50109 AZD 5582 dihydrochloride A Smac mimetic and IAP inhibitor
GC64938 AZD-7648 An inhibitor of DNA-PK
GC73016 AZD4877 AZD4877是Ispinesib的另一种同分异构体，也是一种激酶纺锤体蛋白（Eg5）抑制剂，IC50为2 nM。
GC46904 Azoxystrobin
嘧菌酯
A broad-spectrum fungicide
GC60616 AZT triphosphate
3'-Azido-3'-deoxythymidine-5'-triphosphate

AZTtriphosphate(3'-Azido-3'-deoxythymidine-5'-triphosphate)是一种Zidovudine(AZT)的活性三磷酸酯代谢产物。AZTtriphosphate具有抗逆转录病毒的活性，并抑制HIV复制。AZTtriphosphate还可抑制HBV的DNA聚合酶。AZTtriphosphate可激活线粒体介导的凋亡(apoptosis)途径。
GC60617 AZT triphosphate TEA
3'-Azido-3'-deoxythymidine-5'-triphosphate TEA
AZTtriphosphateTFA(3'-Azido-3'-deoxythymidine-5'-triphosphateTFA)是一种Zidovudine(AZT)的活性三磷酸酯代谢产物。AZTtriphosphateTFA具有抗逆转录病毒的活性，并抑制HIV复制。AZTtriphosphateTFA还可抑制HBV的DNA聚合酶。AZTtriphosphateTFA可激活线粒体介导的凋亡(apoptosis)途径。
GC72817 BAI1 hydrochloride BAI1 hydrochloride是一种选择性凋亡因子BAX变构抑制剂。
GC52344 Bak BH3 (72-87) (human) (trifluoroacetate salt) A Bak-derived peptide
GC60620 Batabulin
巴他布林; T138067
An inhibitor of tubulin polymerization
GC60621 Batabulin sodium
T138067 sodium
An inhibitor of tubulin polymerization
GC52476 Bax Inhibitor Peptide V5 (trifluoroacetate salt)
BIP V5, VPMLK
A Bax inhibitor
GC62164 BAY1082439
N-[8-[[(2R)-2-羟基-3-(吗啉-4-基)丙基]氧基]-7-甲氧基-2,3-二氢咪唑并[1,2-C]喹唑啉-5-基]-2-甲基吡啶-3-甲酰胺
An inhibitor of PI3Kα, PI3Kβ, and PI3Kδ
GC68744 BC-?1258 BC-1258 是一种 F-box/LRR-重复蛋白 2 (FBXL2) 激活剂，可以稳定和上调 FBXL2 水平。BC-1258 诱导致瘤细胞凋亡，并显着抑制小鼠的肿瘤形成。
GC73928 BDM19 BDM19并单独或与BCL-2/BCL-XL抑制剂Navitoclax联合诱导细胞凋亡。
GC72851 Belapectin
GR-MD-02
Belapectin (GR-MD-02)是半乳糖凝集素-3 （Gal-3）抑制剂。
GC49042 Benastatin A A bacterial metabolite with diverse biological activities
GC64354 Bendamustine
宾达氮芥,SDX-105 free base
Bendamustine (SDX105) is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.
GC46914 Bendamustine-d4 (hydrochloride)
盐酸苯达莫司汀 d4 (盐酸盐)
A neuropeptide with diverse biological activities
GC49781 Benomyl
苯菌灵
A carbamate pesticide
GC74515 Benufutamab
GEN1029
Benufutamab（GEN1029）是一种死亡受体5（DR5）特异性激动抗体。