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Home >> Signaling Pathways >> Immunology/Inflammation >> Apoptosis

Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Products for  Apoptosis

  1. Cat.No. 产品名称 Information
  2. GC39551 BRD3308 An HDAC3 inhibitor
  3. GC62536 Bromelain

    菠萝蛋白酶

     A mixture of proteolytic enzymes
  4. GC70853 Broussochalcone A Broussochalcone A是黄嘌呤氧化酶的抗氧化剂和抑制剂(IC50=2.21 μM)，具有清除自由基的活性。
  5. GC39355 BTSA1 BTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
  6. GC46962 Busulfan-d8

    白消安 d8

     An internal standard for the quantification of busulfan
  7. GC48433 BX-320

    N1-[3-[[5-溴-2-[[3-[(1-吡咯烷基羰基)氨基]苯基]氨基]-4-嘧啶基]氨基]丙基]-2,2-二甲基丙烷二酰胺

     An inhibitor of PDK1
  8. GC46989 C18 dihydro Ceramide-d3 (d18:0/18:0-d3)

    N-octadecanoyl-D-erythro-Dihydrosphingosine-d3

     An internal standard for the quantification of C18 dihydro ceramide
  9. GC40141 C18 Phytoceramide-d3 (t18:0/18:0-d3)

    Cer(t18:0/18:0) - d3, Ceramide (t18:0/18:0)- d3, N-Octadecanoyl Phytosphingosine- d3, C18:0 Phytoceramide- d3, N-Stearoyl Phytosphingosine- d3

     An internal standard for the quantification of C18 phytoceramide
  10. GC43105 C8 Ceramide (d18:1.8:0)

    N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine

     A cell-permeable ceramide analog
  11. GC47016 Cabergoline-d6

    FCE-21336-d6

     A neuropeptide with diverse biological activities
  12. GC60668 Calcimycin hemimagnesium

    CALIMYCIN半镁盐,A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium

     Calcimycin(A-23187)hemimagnesium是一种抗生素和独特的二价阳离子离子载体(divalentcationionophore)，如钙离子和镁离子。Calcimycinhemimagnesium通过增加细胞内钙浓度诱导Ca2+依赖性细胞死亡。Calcimycinhemimagnesium抑制革兰氏阳性细菌和一些真菌的生长，还抑制ATP酶的活性并解耦哺乳动物细胞的氧化磷酸化(OXPHOS)，诱导细胞凋亡(apoptosis)。
  13. GC65081 CALP1 TFA CALP1 TFA 是一种钙调蛋白 (CaM) 激动剂 (Kd 为 88 µM)，与 CaM EF-hand/Ca2+ 结合位点结合。CALP1 TFA 通过抑制钙通道 (calcium channel) 的开放来阻止钙的流入和凋亡 (IC50 为 44.78 µM)。CALP1 TFA 阻止谷氨酸受体 ( glutamate receptor channels) 通道，并阻止存储操作的非选择性阳离子通道。CALP1 TFA 激活 CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性。
  14. GC18315 Calpain Inhibitor VI

    SJA6017

     A calpain and cathepsin inhibitor
  15. GC68826 Cantrixil

    TRX-E-002-1

     Cantrixil (TRX-E-002-1) 是 TRX-E-002 的活性对映异构体，是第二代超级苯并吡喃 (SBP) 化合物。Cantrixil 增加磷酸化 c-Jun 水平，导致卵巢癌细胞中半胱天冬酶介导的细胞凋亡。Cantrixil 对广泛的癌症表型具有有效的抗癌活性。
  16. GC49415 Capsorubin

    辣椒紫紅素

     A carotenoid with diverse biological activities
  17. GC18449 Cardanol monoene

    腰果酚(C15:1),Cardanol C15

     An inhibitor of tyrosinase with anticancer properties
  18. GC43144 Carfilzomib Impurity 13 (hydrochloride) A potential impurity found in commercial carfilzomib preparations
  19. GC64110 Carubicin hydrochloride

    盐酸洋红霉素,Carminomycin hydrochloride; Carminomicin I hydrochloride

     An anthracycline with anticancer activity
  20. GC62442 Casein Kinase inhibitor A51 Casein Kinase inhibitor A51 是一种有效且具有口服活性的酪蛋白激酶 1α (CK1α) 抑制剂。Casein Kinase inhibitor A51 可诱导白血病细胞凋亡 (apoptosis)，并具有有效的抗白血病活性。
  21. GC43146 Caspase-9 Inhibitor III (trifluoroacetate salt)

    Ac-LEHD-CMK

     A caspase-9 inhibitor
  22. GC43149 CAY10404 A COX-2 inhibitor
  23. GC18530 CAY10616

    顺式3,4',5-三甲氧基-3'-羟基二苯乙烯

     Pro-apoptotic analog of resveratrol
  24. GC48392 CAY10747 An inhibitor of the Hsp90-Cdc37 protein-protein interaction
  25. GC49080 CAY10786

    GPR52-IN-43

     A GPR52 antagonist
  26. GC52245 CAY10792 An anticancer agent
  27. GC61532 CCI-007

    2-(4-((2-氨基-4-氧代噻唑-5(4H)-亚基)甲基)-2-甲氧基苯氧基)乙酸乙酯

     CCI-007 is a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.
  28. GC39555 CDDO-2P-Im CDDO-2P-Im 是 CDDO 咪唑胺类似物，具有化学预防作用。CDDO-2P-Im 可降低小鼠肺癌模型肺肿瘤的大小和严重程度。
  29. GC39556 CDDO-3P-Im CDDO-3P-Im 是 CDDO 咪唑胺类似物，具有化学预防作用。CDDO-3P-Im 可降低小鼠肺癌模型肺肿瘤的大小和严重程度。
  30. GC62596 CDK7-IN-3

    7-(二甲基膦基)-3-[2-[[(3S)-6,6-二甲基-3-哌啶基]氨基]-5-(三氟甲基)-4-嘧啶基]-1H-吲哚-6-甲腈,CDK7-IN-3

     CDK7-IN-3 (CDK7-IN-3) 是一种具有口服活性的高选择性非共价 CDK7 抑制剂，KD 为 0.065 nM。 CDK7-IN-3 对 CDK2 (Ki=2600 nM)、CDK9 (Ki=960 nM)、CDK12 (Ki=870 nM) 显示出较差的抑制作用。 CDK7-IN-3 诱导肿瘤细胞凋亡并具有抗肿瘤活性。
  31. GC61865 Cearoin

    2,5-二羟基-4-甲氧基二苯甲酮

     Cearoin 通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。
  32. GC49152 Celecoxib Carboxylic Acid

    羧酸塞来昔布

     An inactive metabolite of celecoxib
  33. GC71968 Celosin K Celosin K（化合物8）可以从青藤种子中分离出来。
  34. GC52489 Ceramide (hydroxy) (bovine spinal cord) A sphingolipid
  35. GC52485 Ceramide (non-hydroxy) (bovine spinal cord) A sphingolipid
  36. GC52486 Ceramide Phosphoethanolamine (bovine)

    N-Acyl Ceramide Phosphoethanolamine (d18:1/acyl mixture), CPE, N-acyl-D-erythro-Sphingosylphosphorylethanolamine

     A sphingolipid
  37. GC64993 Chicoric acid

    菊苣酸; Cichoric acid; Dicaffeoyltartaric acid

     A dicaffeoyl ester with diverse biological activities
  38. GC45717 Chlamydocin An HDAC inhibitor
  39. GC91297 Cholesterol-Doxorubicin

    Chol-DOX

    一种阿霉素的前药形式。
  40. GC64028 Chrysosplenol D

    猫眼草酚D

     Chrysosplenol D 是一种甲氧基黄酮类化合物，可在三阴性人乳腺癌细胞中诱导 ERK1/2 介导的细胞凋亡。Chrysosplenol D 还具有抗炎和中等抗锥虫活性。
  41. GC45764 Ciclopirox-d11 (sodium salt)

    HOE 296b-d11

     A neuropeptide with diverse biological activities
  42. GC60708 Cinchonine hydrochloride

    辛可宁盐酸盐; (8R,9S)-Cinchonine hydrochloride; LA40221 hydrochloride

     Cinchoninehydrochloride((8R,9S)-Cinchoninehydrochloride)是金鸡纳树皮中的天然化合物。Cinchoninehydrochloride可激活内质网应激诱导的人肝癌细胞凋亡。
  43. GC52269 Cinnabarinic Acid-d4 An internal standard for the quantification of cinnabarinic acid
  44. GC70418 Cipepofol Cipepofol（Ciprool）是一种新型的2,6-二取代苯酚衍生物，是GABAA受体的正变构调节剂和直接激动剂。
  45. GC35703 Citicoline

    胞磷胆碱; Cytidine diphosphate-choline; CDP-Choline; Cytidine 5'-diphosphocholine

    An intermediate in the synthesis of phosphatidylcholine
  46. GC68873 Citric acid trisodium

    枸椽酸钠; Sodium citrate; Trisodium citrate anhydrous

     Citric acid trisodium 是一种天然防腐剂和食品酸味增强剂。Citric acid trisodium 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期和 S 期。Citric acid trisodium 通过降低抗氧化酶活性引起肝脏的氧化损伤。Citric acid trisodium 对小鼠造成肾毒性。
  47. GC68051 Citric acid-d4

    柠檬酸 d4

     Citric acid-d4 是 Citric acid 的氘代物。Citric acid 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是天然防腐剂和食品添加剂。
  48. GC63393 Citronellyl acetate

    乙酸香茅酯

     Citronellyl acetate (Citronellol acetate) is a natural flavouring ingredient.
  49. GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide

    Biotin-GQGKS(Cit)L(Cit)DLYEEEMRELRRQ, Biotin-GQGKSXLXDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (G146R) (R144 + R146)-biotin

     A biotinylated and citrullinated mutant vimentin peptide
  50. GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide

    Biotin-GQGKS(Cit)LGDLYEEEMRELRRQ, Biotin-GQGKSXLGDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (R144)-biotin

     A biotinylated and citrullinated vimentin peptide
  51. GC39485 CK2/ERK8-IN-1 A dual inhibitor of CK2 and ERK8

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