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Home >> Signaling Pathways >> Immunology/Inflammation >> Apoptosis

Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Products for  Apoptosis

  1. Cat.No. 产品名称 Information
  2. GC72862 Erasin Erasin是一种强效的厄洛替尼抗性拮抗STAT3抑制剂，对STAT3和STAT1的IC50分别为9.7和24μM。
  3. GC52516 Erbstatin

    Antibiotic MH 435A

     A tyrosine kinase inhibitor
  4. GC63845 Eribulin-d3 mesylate

    甲磺酸艾日布林 d3 (甲磺酸盐)

     Eribulin-d3 mesylate 是 Eribulin mesylate 的氘代物。Eribulin mesylate 是靶向微管 (microtubule) 的抗癌剂，可用于研究癌症。
  5. GC60153 Eriocalyxin B

    毛萼乙素

     EriocalyxinB是从中草药枇杷素中分离得到的一种二萜类化合物。EriocalyxinB具有抗癌、抗炎作用。EriocalyxinB诱导细胞凋亡(apoptosis)。
  6. GC61669 Ethyl 3,4-dihydroxybenzoate

    3,4-二羟基苯甲酸乙酯,Ethyl protocatechuate

     Ethyl3,4-dihydroxybenzoate(Ethylprotocatechuate)是一种抗氧化剂，是一种在花生种子的种皮中发现的脯氨酰羟化酶(prolyl-hydroxylase)抑制剂。Ethyl3,4-dihydroxybenzoate通过激活NO合酶(NOsynthase)并产生线粒体ROS来保护心肌。Ethyl3,4-dihydroxybenzoate可诱导ESCC细胞自噬(autophagy)和凋亡(apoptosis)。Ethyl3,4-dihydroxybenzoate是胶原蛋白合成抑制剂，具有骨骼保护作用。
  7. GC60824 Ethylene dimethanesulfonate

    乙二磺酸乙烯酯

     Ethylenedimethanesulfonate是一种温和的烷基化乙二醇非挥发性甲烷磺酸二酯。Ethylenedimethanesulfonate对LC具有选择性的促凋亡作用。
  8. GC60826 Etoposide phosphate

    磷酸依托泊苷; BMY-40481

     Etoposidephosphate(BMY-40481)是一种有效的抗癌(anti-cancer)化疗试剂和一种选择性拓扑异构酶II(topoisomeraseII)抑制剂，可以防止DNA链的重新连接。Etoposidephosphate是依托泊苷的磷酸酯前药，被认为与Etoposide活性相当。Etoposidephosphate诱导细胞周期阻滞、凋亡(apoptosis)和自噬(autophagy)。
  9. GC60157 Euphorbia Factor L2

    大戟因子L2

     Euphorbia factor L2 是从大戟种子中分离得到的一种赤藓烷二萜 (Euphorbia lathyris L.)，传统上用于治疗癌症。Euphorbia factor L2 显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡。
  10. GC74252 Euphornin Euphornin是一种抗癌剂，可从E. helioscopia中分离得到。
  11. GC73294 F5446 F5446（化合物1）是SUV39H1金属转移酶的选择性小分子抑制剂。
  12. GC62203 Falcarindiol

    法卡林二醇

     Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
  13. GC73629 FB49 FB49是一种高选择性的bcl -2相关的无氧基因3 （BAG3）抑制剂，Ki为45 μM。
  14. GC73543 FC-116 FC-116是一种有效抑制小鼠肿瘤生长的微管蛋白抑制剂。
  15. GC60836 Fenobucarb

    仲丁威

     Fenobucarb是一种广泛使用的氨基甲酸酯杀虫剂。Fenobucarb通过炎症、氧化应激、变性和凋亡等途径诱导斑马鱼发育神经毒性。Fenobucarb可能对动物心脑血管系统有危害。
  16. GC50190 Fenretinide - d4

    4-HPR-d4, 4-Hydroxy(phenyl)retinamide-d4, Retinoic Acid p-hydroxyphenylamide-d4

     An internal standard for the quantification of fenretinide
  17. GC69105 FG-3019

    Pamrevlumab; Anti-Human CTGF Recombinant Antibody

     FG-3019 (Pamrevlumab) 是一种重组人源化抗体，可与结缔组织生长因子 (CTGF) 结合。FG-3019 可用于特发性肺纤维化 (IPF) 的研究。
  18. GC49344 Fisetin-d5 An internal standard for the quantification of fisetin
  19. GC60845 Flavokawain A

    2'-羟基-4,4',6'-三甲氧基查耳酮

     A chalcone with diverse biological activities
  20. GC62167 Fluorizoline Fluorizoline 选择性地直接结合到 prohibitin 1 (PHB1) 和 2 (PHB2)，并诱导凋亡。Fluorizoline 通过上调 NOXA 和 BIM 降低慢性淋巴细胞性白血病 (CLL) 细胞的活力。Fluorizoline 以 p53 非依赖性方式发挥抗肿瘤作用。
  21. GC73631 FPR1 antagonist 1 FPR1 antagonist 1（化合物24a）是甲酰肽受体1（FPR1）拮抗剂，IC50为25nM。
  22. GC12604 Fumonisin B1

    伏马菌素B1

    A mycotoxin
  23. GC52288 Fumonisin B1-13C34

    FB1-13C34

     An internal standard for the quantification of fumonisin B1
  24. GC62981 Furanodienone

    呋喃二烯酮

     Furanodienone 是源自姜黄根茎 Rhizoma Curcumae 的主要生物活性成分之一。Furanodienone 诱导细胞凋亡 (apoptosis)。
  25. GC18611 Fusicoccin

    壳梭孢(菌)素,Fusicoccin A

     A phytotoxin
  26. GC39382 FW1256 FW1256 是一种苯基类似物，也是一种缓释硫化氢 (H2S) 供体。FW1256 抑制 NF-κB 活性，并可诱导细胞凋亡 (apoptosis)，并可用于癌症，炎症和心血管疾病的研究。
  27. GC62246 G5-7 G5-7 is an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2.
  28. GC38610 Galgravin

    盖尔格拉文

     A lignan with diverse biological activities
  29. GC61436 Gallic acid hydrate

    没食子酸-水合物; 3,4,5-Trihydroxybenzoic acid hydrate

     A phenol with diverse biological activities
  30. GC70257 Gallium maltolate Gallium maltolate（GAM）是一种具有抗癌和抗炎活性的细胞凋亡诱导剂。
  31. GC73002 Ganglioside GD3 diammonium Ganglioside GD3 diammonium是一种酸性鞘糖脂。
  32. GC47393 Ganglioside GM1 Mixture (porcine brain) (ammonium salt)

    GM1, Monosialoganglioside GM1

     A sphingolipid
  33. GC74721 Geraniol-d6 (Major) Geraniol-d6 (Major)是氘代标记的Geraniol Major。
  34. GC62633 GGTI-2154 GGTI-2154 是一种有效和选择性的 geranylgeranyltransferase I (GGTase I) 抑制剂，IC50 值为 21 nM。GGTI-2154 对 GGTase I 的选择性是 FTase (IC50=5600 nM) 的 200 倍以上。GGTI-2154 可用于癌症的研究。
  35. GC73980 GGTI-2417 GGTI-2417是GGTase I的强效选择性抑制剂。
  36. GC31717 Ginkgetin

    银杏双黄酮

     A biflavonoid with diverse biological activities
  37. GC20007 Ginsenoside CK

    20(S)-人参皂苷 C-K; Compound K

    Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.
  38. GC60173 Ginsenoside F5

    人参皂苷F5

     GinsenosideF5，可从Panaxginseng中提物，通过凋亡(apoptosis)途径显着抑制HL-60细胞生长。
  39. GC62988 Girinimbine

    吉九里香碱,Girinimbin

     Girinimbine (Girinimbin) 是一种咔唑类生物碱，具有多种生物学作用。Girinimbine 可诱导细胞凋亡 (apoptosis)，具有抗锥虫、抗血小板活性、抗菌活性、抗炎、抗氧化和抗肿瘤活性。
  40. GC49437 Gliotoxin-13C13

    Aspergillin-13C13

     An internal standard for the quantification of gliotoxin
  41. GC43762 GLP-1 (7-36) amide (trifluoroacetate salt)

    Glucagon-like Peptide 1 (7-36) amide

     A GLP-1R agonist
  42. GC91162 Glucosamine Cholesterol

    一种基于葡萄糖胺的脂质共轭物
  43. GC73808 Glutor Glutor是一种选择性GLUT 1/2/3抑制剂，可以抑制葡萄糖摄取。
  44. GC40758 Gly-Phe-β-naphthylamide

    (S)-2-(2-氨基乙酰氨基)-N-(萘-2-基)-3-苯基丙酰胺

     A cathepsin C substrate
  45. GC69178 Glychionide A

    去甲汉黄芩素-7-O-葡萄糖醛酸苷

     Glychionide A 是一种黄酮苷，存在于 Glychirriza glabra 的根中。Glychionide A 促进 PANC-1 胰腺癌细胞的凋亡和自噬。Glychionide A 可用于癌症的研究。
  46. GC47407 Glycochenodeoxycholic Acid (sodium salt hydrate)

    GCDCA, NSC 681056

     A neuropeptide with diverse biological activities
  47. GC60882 Glyphosate

    草甘膦

     An herbicide
  48. GC73822 GNE-900 GNE-900是一种ATP竞争性、选择性和口服活性的ChK1抑制剂，ChKl和ChK2的IC50分别为0.0011和1.5µM。
  49. GC72018 Goniothalamin Goniothalamin（GTN）是一种具有抗癌、抗炎和免疫抑制特性的苯乙烯基内酯。
  50. GC39640 GPLGIAGQ TFA

    GPLGIAGQ TFA 是一种 MMP2 可切割的多肽，在脂质体和胶束纳米载体中都被用作刺激敏感的连接物，用于 MMP2 触发的肿瘤靶向治疗。GPLGIAGQ TFA可用于合成光动力治疗 (PDT) 中独特的 MMP2 靶向光敏剂。
  51. GC39489 GPNA hydrochloride

    Γ-(P-硝基苯胺)-L-谷氨酸盐酸盐

     GPNA (L-γ-Glutamyl-p-nitroanilide) is a potent and selective inhibitor of the glutamine (Gln) transporter ASCT2(SLC1A5) with Ki of 55 ?M.

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