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Home >> Signaling Pathways >> Immunology/Inflammation >> Apoptosis

Apoptosis(凋亡)

FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Products for  Apoptosis

  1. Cat.No. 产品名称 Information
  2. GC63934 Karanjin

    水黄皮素

     Karanjin 是 Fordia cauliflora 中主要的活性呋喃黄酮醇成分。Karanjin 通过提高 AMPK 的方式诱导骨骼肌细胞 GLUT4 易位。Karanjin 可通过细胞周期阻滞诱导癌细胞死亡，促进细胞凋亡。
  3. GC60962 Kauran-16,17-diol

    ent-Kauran-16β,17-diol

     Kauran-16,17-diol(ent-Kauran-16β,17-diol)是一个天然的二萜化合物，具有抗肿瘤诱导凋亡的活性。其抑制LPS诱导的RAW264.7细胞产生NO的IC50值为17μM。
  4. GC71624 Ketoprofen-d4 Ketoprofen-d4是氘标记的酮洛芬。
  5. GC73594 KH16 KH16是一种有效的低纳摩尔HDAC抑制剂。
  6. GC44006 Kinsenoside

    金线莲苷

     A glycoside with diverse biological activities
  7. GC64370 Kongensin A Kongensin A 是一种从 Croton kongensis 中分离的天然产物。 Kongensin A 是一种有效的，共价的 HSP90 抑制剂，可阻断 RIP3 依赖性坏死病。Kongensin A 是一种有效的坏死性抑制剂和凋亡诱导剂，并具有潜在的抗坏死性和消炎性应用。
  8. GC72103 Kp7-6 Kp7-6是一种Fas模拟肽，是一种Fas/FasL拮抗剂。
  9. GC60969 KRAS inhibitor-9

    4-(苯并[D]噻唑-2-基硫基)-3-氯苯胺

     KRASinhibitor-9是有效的KRAS抑制剂(Kd=92μM)，阻止GTP-KRAS的形成和KRAS下游激活。KRASinhibitor-9以中等的结合亲和力与KRASG12D，KRASG12C和KRASQ61H蛋白结合。KRASinhibitor-9导致G2/M细胞周期停滞并诱导凋亡(apoptosis)。KRASinhibitor-9选择性抑制具有KRAS突变的NSCLC细胞的增殖，但不抑制正常肺细胞的增殖。KRASinhibitor-9
  10. GC18909 KRIBB3 An Hsp7 and inhibitor of microtubule polymerization
  11. GC73159 KTX-582 KTX-582是一种有效的IRAK4降解剂，IRAK4和Ikaros的DC50值分别为4nM和5nM。
  12. GC39062 Kumatakenin

    熊竹素

     A flavonoid with diverse biological activities
  13. GC72824 KX2-361

    KX-02

     KX2-361（KX-02）是一种Src激酶和微管蛋白聚合抑制剂。
  14. GC71617 L-Ascorbic acid-13C-2 L-Ascorbic acid-13C-2是13C标记的L-抗坏血酸。
  15. GC72511 L-Cystathionine dihydrochloride L-Cystathionine dihydrochloride是一种非蛋白硫醚，是与含硫氨基酸代谢状态相关的关键氨基酸。
  16. GC72575 L-Glutamic acid monosodium (hydrate) L-Glutamic acid monosodium (hydrate)是一种营养添加剂和调味剂。
  17. GC64352 L-Glutamic acid-15N

    L-谷氨酸 15N

     L-Glutamic acid-15N 是一种 15N 标记的 L-Glutamic acid。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。
  18. GC65095 L-Glutamic acid-d5

    L-谷氨酸 d5

     L-Glutamic acid-d5 是 L-Glutamic acid 的氘代物。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。
  19. GC44085 L-Sulforaphene

    莱菔素

     A natural isothiocyanate
  20. GC69405 L-Theanine-d5

    L-Glutamic Acid γ-ethyl amide-d5; Nγ-Ethyl-L-glutamine-d5

     L-Theanine-d5 是 L-Theanine 的氘代物。L-Theanine (L-Glutamic Acid γ-ethyl amide）是一种存在绿茶叶片中的非蛋白氨基酸物质, 能阻断大脑中谷氨酸与谷氨酸受体结合，具有神经保护和抗氧化活性。 能通过口服 L-Theanine (L-Glutamic Acid γ-ethyl amide） 抑制皮层神经元兴奋从而产生抗应激作用 。
  21. GC44087 L-threo-PPMP (hydrochloride)

    L-threo-1-phenyl-2-Palmitoylamino-3-morpholino-1-propanol

     An inhibitor of glucosylceramide synthetase
  22. GC60221 Lactoferrin (17-41) (acetate)

    Lactoferricin B acetate; Lfcin B acetate

     Lactoferrin 17-41 (Lactoferricin B) acetate 对应于牛乳铁蛋白的残基 17-41，对革兰氏阳性和革兰氏阴性细菌、病毒、原生动物和真菌等多种微生物具有抗菌活性。Lactoferrin 17-41 acetate 具有抗肿瘤活性。
  23. GC40222 Lapatinib-d4 (tosylate) An internal standard for the quantification of lapatinib
  24. GC39209 LCH-7749944

    GNF-PF-2356

     LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4.
  25. GC63592 LCS-1

    4,5-二氯-2-(3-甲苯基)哒嗪-3-酮

     An inhibitor of SOD1
  26. GC49753 LCS3 An inhibitor of glutathione reductase and thioredoxin reductase
  27. GC69364 LDCA LDCA 是一种双重打击代谢调节剂，可抑制 LDH-A 酶活性，刺激恶性群体的凋亡。LDCA 可用于致癌进展的研究。
  28. GC74486 Lexatumumab

    来沙木单抗; HGS-ETR 2; ETR2-ST01

     Lexatumumab（HGS-ETR 2）是一种人激动性TRAIL受体2（TRAIL-R2、DR5、APO-2）IgG4κ型单克隆抗体。
  29. GC64325 Ligustilide

    蒿本内酯

     Ligustilide is the most abundant bioactive ingredient in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments. Solutions are best fresh-prepared.
  30. GC74572 Lilotomab

    利洛托单抗; HH1

     Lilotomab(0-40µg/mL；12 d)降低DOHH2和Ramos细胞的克隆性存活。
  31. GC69379 Lipid 8 Lipid 8 是一种可电离的氨基脂质，可用于合成脂质纳米颗粒。
  32. GC69380 Lirentelimab

    AK002; Anti-Siglec-8 Reference Antibody (lirentelimab)

     Lirentelimab (AK002) 是一种人源化 IgG1 单克隆抗体，靶向唾液酸结合的 Ig 样凝集素 8 (SIGLEC8)。Lirentelimab 诱导 IL-5 激活的嗜酸性粒细胞细胞凋亡并抑制 IL-5 介导的肥大细胞激活。Lirentelimab 可用于嗜酸性胃炎、十二指肠炎的研究。
  33. GC60997 Lixisenatide acetate Lixisenatideacetate是胰高血糖素样肽1受体(GLP-1R)的激动剂，可用于2型糖尿病的研究。
  34. GC91967 LMTK3 Inhibitor C28

    Lemur Tyrosine Kinase 3-IN-1; Lemur Tyrosine Kinase-IN-C28; Lemur Tyrosine Kinase 3 Inhibitor 1; Lemur Tyrosine Kinase Inhibitor C28; LMTK3-IN-1; LMTK3-IN-C28; LMTK3 Inhibitor 1

     LMTK3 Inhibitor C28是一种多激酶抑制剂。
  35. GC49177 Loliolide

    地芰普内酯

     A monoterpene lactone with diverse biological activities
  36. GC39820 Lometrexol hydrate

    洛美曲索水合物,DDATHF hydrate

     A GART inhibitor
  37. GC40909 Lonicerin

    忍冬苦苷

     A flavonoid with diverse biological activities
  38. GC72933 LQZ-7F LQZ-7F是一种survivin二聚化抑制剂，在前列腺癌细胞中诱导自发凋亡并与多西他赛协同作用。
  39. GC67936 Lupiwighteone

    黄羽扇豆魏特酮; 8-prenylgenistein

     Lupiwighteone 是一种广泛存在于野生植物中的异黄酮，具有抗氧化、抗菌和抗癌作用。Lupiwighteone 通过抑制 PI3K/Akt/mTOR 通路，诱导人乳腺癌细胞 caspase 依赖性和非依赖性凋亡 (Apoptosis)。
  40. GC50009 LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases
  41. GC44096 LY293111

    Etalocib; VML 295

     A LTB4 receptor antagonist
  42. GC38967 Lycorine

    石蒜碱

     An alkaloid with diverse biological activities
  43. GC18241 Lysophosphatidylcholines

    L-溶血卵磷脂,Lyso-Lecithins (egg)

     A glycerophospholipid
  44. GC73199 M47 M47是一种小分子，选择性地破坏隐色素1 （CRY1）的稳定性，并增加细胞核中CRY1的降解。
  45. GC90483 Magainin 1 (trifluoroacetate salt)

    MG1

    一种抗微生物阳离子肽。
  46. GC61021 Malachite green oxalate

    孔雀石绿草酸盐

     Malachite green (Aniline green, Basic green 4, Diamond green B, Victoria green B) is a synthetic dyestuff and antimicrobial with potential carcinogenicity.
  47. GC40007 Malformin A

    Malformin A1

     A cyclopentapeptide fungal metabolite with diverse biological activities
  48. GC63058 Malvidin-3-galactoside chloride

    氯化锦葵色素-3-O-半乳糖苷

     Malvidin-3-galactoside chloride 是一种花青素单体，可诱导肝细胞癌 (HCC) 细胞周期停滞和凋亡。Malvidin-3-galactoside chloride 抑制 ROS 的产生和积累。Malvidin-3-galactoside chloride 具有抗肿瘤功能。
  49. GC18363 Mca-DEVDAPK(Dnp)-OH

    Caspase-3 Fluorogenic Substrate III, CPP32 Fluorogenic Substrate III, 7-Methoxycoumarin-4-acetyl-DEVDAPK(Dnp)-OH, Mca-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH

     A caspase-3 fluorogenic substrate
  50. GC44135 Mca-VDQMDGW-K(Dnp)-NH2 (ammonium salt)

    Caspase-3 Fluorogenic Substrate V

     A caspase-3 fluorogenic substrate
  51. GC62252 Mefuparib hydrochloride

    MPH

     Mefuparib hydrochloride (MPH) 是一种具有口服活性的，底物竞争性和选择性的 PARP1/2 抑制剂，IC50 分别为 3.2 nM 和 1.9 nM。Mefuparib hydrochloride 诱导细胞凋亡 (apoptosis)，并在体内外具有显着的抗癌活性。

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