NF-κB
NF-κB is a family of conserved and ubiquitous transcription factors that involved in various biological processes including immunity, inflammation, cell growth, differentiation and apoptosis. It is associated with cancer, chronic inflammation and arthritis etc.
Products for NF-κB
- Cat.No. 产品名称 Information
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GC91175
NCI 126224
NSC 126224
一种TLR4拮抗剂
- GC44353 NDMC101 A salicylanilide derivative
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GN10103
Neferine
甲基莲心碱; (-)-Neferine
An alkaloid with diverse biological activities -
GN10429
Neochlorogenic acid
新绿原酸; trans-5-O-Caffeoylquinic acid
A phenolic compound with diverse biological activities -
GC60267
Neocryptotanshinone
新隐丹参酮
Neocryptotanshinone是可从SalviaMiltiorrhiza分离得到的一种丹参二萜,通过抑制NF-κB和iNOS信号来抑制LPS诱导的炎症。 -
GC48985
NF-κB Inhibitor (trifluoroacetate salt)
SN50 Peptide
A cell-permeable peptide that blocks nuclear import of NF-κB - GC69555 NF-κB-IN-4 NF-κB-IN-4 (化合物 17) 是一种有效的可透过血脑屏障的 NF-κB 通路抑制剂。NF-κB-IN-4 表现出潜在的低毒性抗神经炎症活性。NF-κB-IN-4 可阻断 IκBα 的激活和磷酸化,降低 NLRP3 的表达,从而抑制 NF-κB 的激活。NF-κB-IN-4 可用于神经炎症相关疾病的研究。
- GC69556 NF-κB/MAPK-IN-1 NF-κB/MAPK-IN-1 (compound 11a) 是一种有效的 NF-κB 和 MAPK 通路抑制剂。NF-κB/MAPK-IN-1 对 NO 生成具有抑制作用,其 IC50 为6.96 μM。NF-κB/MAPK-IN-抑制 LPS 诱导的 iNOS,COX-2,ERκ 和 P38 激活。 NF-κB/MAPK-IN-1 可抑制 LPS 诱导的巨噬细胞炎症反应。 NF-κB/MAPK-IN-1 可用于类风湿关节炎 (RA) 的研究。
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GC11736
NF-κB Activation Inhibitor III
SM-7368
An inhibitor of NF-κB activation -
GC31733
NIK SMI1
NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP.
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GC36794
Okanin
奥卡宁
Okanin 是 Coreopsis tinctoria 的有效成分。Okanin 通过抑制 TLR4/NF-κB 信号通路减弱 LPS 诱导的小胶质细胞活化。 -
GN10756
Ophiopogonin D
麦冬皂苷D
A steroid glycoside with diverse biological activities -
GC12114
Oxaprozin
奥沙普秦; Oxaprozinum; Wy21743
An NSAID and COX inhibitor -
GC49024
Palmitic Acid MaxSpec® Standard
棕榈酸
A long-chain saturated fatty acid -
GC49023
Palmitic Acid-d9 MaxSpec® Standard
棕榈酸-13,13,14,14,15,15,16,16,16-D9
A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications -
GN10357
Parthenolide
小白菊内酯; (-)-Parthenolide
A natural inhibitor of NOD2 and NF-κB signaling -
GC60283
Pentagamavunon-1
PGV-1
Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物,具有口服活性,通过多个机制诱导凋亡信号,如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。 -
GC38170
Phellodendrine
黄柏碱
An alkaloid with diverse biological activities -
GN10778
Picroside II
胡黄连苷II
A flavonoid with diverse biological activities -
GN10312
Polygalasaponin F
瓜子金皂苷己
A triterpenoid saponin with diverse biological activities -
GC16657
PPM-18
NSC 73233
Inhibits activation of NF-κB - GC16096 PR 39 (porcine) PR 39(猪)是一种富含脯氨酸和精氨酸的天然抗菌肽,是一种非竞争性、可逆的变构蛋白酶体抑制剂。
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GC45768
Pranlukast-d4
ONO-1078-d4
A neuropeptide with diverse biological activities - GC37036 PTD-p65-P1 Peptide PTD-p65-P1 Peptide 是一种核转录因子 NF-kappaB 抑制剂,由一个 antennapedia 衍生的膜转运肽序列 (PTD) 连接 p65-P1 构成, 选择性地抑制由各种刺激诱导的 NF-kappaB 活性。
- GC38520 PTD-p65-P1 Peptide TFA PTD-p65-P1 Peptide TFA 是一种核转录因子 NF-kappaB 抑制剂,由一个 antennapedia 衍生的膜转运肽序列 (PTD) 连接 p65-P1 构成, 选择性地抑制由各种刺激诱导的 NF-kappaB 活性。
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GC49860
Pyropheophorbide a methyl ester
焦脱镁叶绿酸Α甲酯,Pyropheophorbide-a methyl ester
A photosensitizer -
GC13575
Pyrrolidinedithiocarbamate ammonium
吡咯烷二硫代氨基甲酸铵; Ammonium pyrrolidinedithiocarbamate; PDTC ammonium; APDC
A potent and reversible NF-κB inhibitor with antioxidant properties -
GC11751
QNZ (EVP4593)
N4-[2-(4-苯氧基苯基)乙基]-4,6-喹唑啉二胺,EVP4593
An inhibitor of NF-κB activation -
GC39428
Quinoclamine
灭藻醌
Quinoclamine 是一种萘醌衍生物,是一种 NF-κB 抑制剂。Quinoclamine 具有抗肿瘤活性。 -
GC39081
Reticuline
番荔枝碱
Reticuline 分离自 Litsea cubeba,通过 JAK2/STAT3 和 NF-κB 信号通路显示抗炎作用。Reticuline 还可抑制 TNF-α 和 IL-6 的 mRNA 表达,并降低 JAK2 和 STAT3 的磷酸化水平。 -
GN10784
Rhoifolin
野漆树苷
A flavonoid glycoside with diverse biological activities -
GN10185
Rhynchophylline
钩藤碱
Rhyncholphylline 是一种从钩藤属植物中分离出来的生物碱,在大鼠原代小胶质细胞中显示出对脂多糖 (LPS) 诱导的 NO 产生的有效抑制作用。 - GC16874 Ro 106-9920 An inhibitor of IκBα ubiquitination
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GC33426
Rocaglamide (Rocaglamide A)
楝酰胺,Rocaglamide A; Roc-A
Rocaglamide (Rocaglamide A) 是从 Aglaia 属(楝科)中分离出来的。 -
GC60331
Rubiadin-1-methyl ether
甲基异茜草素-1-甲醚
An anthraquinone with diverse biological activities -
GN10164
Saikosaponin D
柴胡皂苷D
A triterpene saponin with diverse biological activities -
GN10759
Sanggenone C
桑根酮 C
A flavonoid with diverse biological activities -
GN10260
Sarsasapogenin
菝葜皂苷元; Parigenin; Sarsagenin
A steroid sapogenin with diverse biological activities - GC10088 SC75741 An inhibitor of NF-κB
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GN10368
Schisantherin A
五味子酯甲; Gomisin-C; Schizantherin-A; Wuweizi ester-A
A hepatoprotective antioxidant -
GC45561
Sciadopitysin
金松双黄酮
A biflavonoid with diverse biological activities - GC68141 SEMBL SEMBL 是一种有效的 NF-κB 抑制剂。SEMBL 能够抑制 NF-κB-DNA 结合,还抑制 NF-κB 依赖性炎性细胞因子分泌。SEMBL 通过降低 MMP 表达来抑制癌细胞的迁移和侵袭。可用于抗癌研究。
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GN10216
Shikonin
紫草素; C.I. 75535; Isoarnebin 4
A natural product with anti-inflammatory and anti-tumor activity -
GC49002
Sinigrin (hydrate)
黑芥子硫苷酸钾一水;芥子甙单水合物
A glucosinolate with diverse biological activities -
GN10213
Sinomenine Hydrochloride
盐酸青藤碱; Cucoline hydrochloride
A natural anti-inflammatory alkaloid -
GC19523
Sivelestat sodium tetrahydrate
EI546 sodium tetrahydrate; LY544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate
An inhibitor of neutrophil elastase -
GC49049
SMU127
ZINC666243
An agonist of TLR1/2 - GC31642 SN50 SN50, NF-κB细胞通透性抑制肽。
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GC10933
Sodium 4-Aminosalicylate
对氨基水杨酸钠; 4-Aminosalicylic acid sodium salt dihydrate
4-氨基水杨酸钠(4-氨基水杨酸钠盐二水合物)是目前用于耐多药结核病的抗分枝杆菌药物之一。 -
GC12013
Sodium salicylate
水杨酸钠; Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt
水杨酸钠(水杨酸钠盐)抑制环加氧酶 2(COX-2)活性,与转录因子(NF-κB)激活无关。