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Home >> Signaling Pathways >> Immunology/Inflammation >> Reactive Oxygen Species

Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for  Reactive Oxygen Species

  1. Cat.No. 产品名称 Information
  2. GC45226 β-BHC

    β-HCH, β-Hexachlorocyclohexane, β-Lindane

     β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane.
  3. GC41623 β-Elemonic Acid

    β-岚香酮酸

     A triterpene with anticancer activity
  4. GC41502 β-Myrcene

    月桂烯; β-Myrcene

     A terpene with antioxidative properties
  5. GC41262 (±)-α-CMBHC A metabolite of (±)-α-tocopherol
  6. GC41617 (±)-α-Tocopherol

    β-生育酚

     A biologically active form of vitamin E
  7. GC67191 (±)-α-Tocopherol nicotinate (±)-α-Tocopherol nicotinate，维生素 E-烟酸酯，是一种具有口服活性的脂溶性抗氧化剂，能够防止细胞膜脂质过氧化。(±)-α-Tocopherol nicotinate 在血液中可水解为 α -生育酚和烟酸，可用于相关血管疾病的研究。
  8. GC39271 (±)-Naringenin

    (±)-柚皮素

     A citrus-derived flavonoid
  9. GC40355 (±)13-HpODE

    13-Hydroperoxylinoleic acid; Linoleic acid 13-hydroperoxide

     Hydroperoxide mixture derived from linoleic acid
  10. GC40809 (+)-β-Citronellol

    (R)-3,7-二甲基-6-辛烯醇,D-Citronellol; (R)-(+)-β-Citronellol

     A monoterpene
  11. GC63969 (+)-Schisandrin B

    (+)-五味子乙素

     (+)-Schisandrin B 是五味子甲素 B 的一种对映体。Schisandrin B 是从五味子果实中分离出来的有效成分，对啮鼠的肝脏和心脏有抗氧化作用。
  12. GC14049 (-)-Epigallocatechin gallate (EGCG)

    (-)-表没食子儿茶素没食子酸酯,EGCG

     (-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。
  13. GC45248 (-)-FINO2 A ferroptosis inducer
  14. GC38316 (-)-Limonene

    (-)-柠檬烯,(S)-(-)-Limonene

     A monoterpene with diverse biological activities
  15. GC90533 (-)-Pinoresinol

    一种具有多种生物活性的木脂素
  16. GC41700 (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine

    CSTMP

     A stilbene derivative with antioxidant and anticancer activities
  17. GC61668 (E)-3,4-Dimethoxycinnamic acid

    (E)-3,4-二甲氧基肉桂酸; (E)-O-Methylferulic acid

     (E)-3,4-Dimethoxycinnamicacid是3,4-Dimethoxycinnamicacid的低活性异构体。3,4-Dimethoxycinnamicacid是从Securidacainappendiculata中提取和纯化的单体。3,4-Dimethoxycinnamicacid通过ROS介导的信号途径对L-02细胞发挥抗凋亡作用。
  18. GC39747 (E/Z)-GSK5182 (E/Z)-GSK5182 是 (E)-GSK5182 和 (Z)-GSK5182 的消旋体。GSK5182 是一种高效选择性，具有口服活性的 ERRγ 反向激动剂，其 IC50 值为 79 nM。GSK5182 还能增加肝癌细胞中 reactive oxyen species (ROS) 的产生。
  19. GC41721 (R)-α-Lipoic Acid

    硫辛酸; (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid

     A cyclic disulfide antioxidant
  20. GC41837 1,3,7-Trimethyluric Acid

    1,3,7-三甲基尿酸,8-oxo Caffeine, NSC 11259

     A metabolite of caffeine
  21. GC46387 1,3,7-Trimethyluric Acid-d9

    TMU-d9, 8-oxo Caffeine-d9

     An internal standard for the quantification of 1,3,7-trimethyluric acid
  22. GC35037 1,3-Dicaffeoylquinic acid

    1,3-二咖啡酰奎宁酸; 1,3-O-Dicaffeoylquinic acid; 1,5-Dicaffeoylquinic acid

     An HIV-1 integrase inhibitor and free radical scavenger
  23. GC46481 1-Hydroxyphenazine

    1-羟基吩嗪

     A P. aeruginosa virulence factor
  24. GC18235 1-O-Hexadecyl-sn-glycerol

    鲛肝醇,α-Chimyl Alcohol, (S)-(+)-Chimyl Alcohol

     An alkyl glyceryl ether
  25. GC40146 1-Oleoyl-2-Palmitoyl-rac-glycerol

    18:1/16:0-DG, DG(18:1/16:0/0:0), 1,2-OP, 1-Olein-2-Palmitin

     A diacylglycerol
  26. GC41866 10-methyl-9-(phenoxycarbonyl) Acridinium (trifluoromethylsulfonate)

    9-[(苯氧基)羰基]-10甲基三氟甲酰胺磺酸盐

     A chemiluminescent acridinium ester
  27. GC41868 10-Nitrooleate

    10-硝基油酸,CXA-10

     A novel endogenous lipid signalling molecule
  28. GC67628 2',7'-Dichlorofluorescein

    2',7'-二氯荧光素；二氯荧光黄；二氯荧光素；2,7-二氯-3,6-萤烷二醇；2,7-二氯荧光黄

     2',7'-Dichlorofluorescein是一种荧光探针，可用于测量活性氧 (ROS) (Ex=496 nm 和 Em=525 nm)。
  29. GC42079 2',7'-Dichlorofluorescein diacetate

    双氯荧光黄乙酸乙酯,DCFH2-DA

     A cell-permeable fluorogenic probe to quantify ROS and NO
  30. GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO
  31. GC72574 2-Oxopropanoate-13C5 sodium 2-Oxopropanoate-13C5 sodium是13C标记的2-氧丙酸钠。
  32. GC35095 2-Phospho-L-ascorbic acid trisodium salt

    L-抗坏血酸-2-磷酸三钠盐; 2-Phospho-L-ascorbic acid trisodium

    Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products.
  33. GC49005 2S-Eriodictyol

    圣草酚; Huazhongilexone

     A flavanone with antioxidant activity
  34. GN10006 3,4-Dihydroxybenzaldehyde

    原儿茶醛; 3,4-二羟基苯甲醛; Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV

     A polyphenol with diverse biological activities
  35. GC33992 3,4-Dimethoxycinnamic acid (O-Methylferulic acid)

    3,4-二甲氧基肉桂酸; O-Methylferulic acid

     3,4-Dimethoxycinnamic acid (Caffeic acid dimethyl ether) is a bioavailable coffee component as a perspective anti-prion compound and bind potently to prion protein with a Kd of 405 nM.
  36. GC61673 3,5-Di-tert-butylphenol

    3,5-二叔丁基苯酚

     3,5-Di-tert-butylphenol是一种具有抗生物膜和抗真菌活性的挥发性有机化合物。3,5-Di-tert-butylphenol会引起活性氧(ROS)的积累。
  37. GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate

    3-HPPA sulfate

     A metabolite of certain phenols and glycosides
  38. GC14282 3-acetyl-11-keto-β-Boswellic Acid

    11-羰基-Β-乙酰乳香酸,3-O-acetyl-11-keto-β-Boswellic acid,AKBA

     A selective 5-LO inhibitor
  39. GC49849 3-Aminosalicylic Acid

    3-氨基水杨酸

     A salicylic acid derivative
  40. GC42251 3-Bromotyrosine (trifluoroacetate salt)

    3-bromo-Tyr

     A product of protein oxidation
  41. GC62794 3-Demethylcolchicine

    3-去甲秋水仙碱

     An active metabolite of colchicine
  42. GC49364 3-Hydroxycoumarin

    3-羟基香豆素

     A coumarin with diverse biological activities
  43. GC45337 3-Hydroxyterphenyllin

    NSC 299113

     A fungal metabolite with diverse biological activities
  44. GC31290 3-Indolepropionic acid

    吲哚-3-丙酸,Indole-3-propionic acid; 3-IPA

     A bacterial metabolite with antioxidant and neuroprotective activities
  45. GC42338 4-Aminobenzoic Acid hydrazide

    4-氨基苯甲酰肼,p-Aminobenzohydrazide; p-Aminobenzoic acid hydrazide

     An MPO inhibitor
  46. GC42351 4-carboxy TEMPO

    4-羧基-2,2,6,6-四甲基氮杂环己烷-1-氧基自由基

     A spin label
  47. GC42401 4-hydroperoxy Cyclophosphamide

    培磷酰胺,4-OOH-CY

     4-hydroperoxy Cyclophosphamide（4-羟基过氧化环磷酰胺），环磷酰胺的活性代谢产物，能够交联DNA并独立于caspase受体激活诱导T细胞凋亡，通过产生活性氧（ROS）激活线粒体死亡途径。
  48. GC18858 4-hydroxy Alternariol

    4-羟基格链孢酚

     A metabolite of alternariol
  49. GC72066 4-Methyl-6-phenyl-2H-pyranone 4-Methyl-6-phenyl-2H-pyranone可用于合成N-羟基吡啶酮衍生物，其可以保护星形胶质细胞免受过氧化氢诱导的毒性。
  50. GC40477 4-Thiouracil

    4-硫尿嘧啶

     A photoreactive nucleobase analog
  51. GC49339 5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate

    5[6]-羧基-2',7'-二氯荧光素二乙酸酯

     An oxidant-sensitive fluorescent probe

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