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Home >> Signaling Pathways >> Immunology/Inflammation >> Reactive Oxygen Species

Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for  Reactive Oxygen Species

  1. Cat.No. 产品名称 Information
  2. GC20095 5,7-Dihydroxy-4-methylcoumarin

    NSC 5302

     A synthetic coumarin with diverse biological activities
  3. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone

    (±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL

     An active metabolite of various polyphenols
  4. GC90889 5-(3'-Hydroxyphenyl)-γ-Valerolactone

    δ-(3'-Hydroxyphenyl)-γ-Valerolactone, 5-(3'-Hydroxyphenyl)-γ-VL, δ-(3'-Hydroxyphenyl)-γ-VL, (3'-hydroxy)-PVL

    多种多酚的代谢产物。
  5. GC45357 5-Chlorouracil

    5-氯尿嘧啶

     A chlorinated derivative of uracil
  6. GC49233 5-Feruloylquinic Acid

    5-O-阿魏酰奎尼酸

     A chlorogenic acid with antioxidant activity
  7. GC39760 5-Galloylquinic acid

    5-没食子酰基奎宁酸

     5-Galloylquinic acid 是绿茶中活性氧 (ROS) 的主要清除剂。
  8. GC46033 5-Heneicosylresorcinol

    5-二十一烷基间苯二酚,5-Heneicosylresorcinol

     An alkylresorcinol
  9. GC61638 5-Hydroxyoxindole

    2-甲基-6-喹啉甲酸

     5-Hydroxyoxindole是尿酸的一种结构类似物。5-Hydroxyoxindole具有自由基DPPH清除活性和脂质过氧化抑制活性。5-Hydroxyoxindole可用于氧化应激介导的疾病的研究。
  10. GC46079 5-Tricosylresorcinol

    5-二十三烷基间苯二酚

     An alkylresorcinol
  11. GC49864 6-Methylpterin

    2-氨基-6-甲基吡嗪并吡啶-4(1H)-酮

     A derivative of folic acid
  12. GC18776 6α-hydroxy Cholesterol

    6α-OHC

     An oxysterol
  13. GC46080 7,3',4'-Trihydroxyflavone

    3',4',7-三羟基黄酮

     A flavonoid with diverse biological activities
  14. GC63640 7-Hydroxyflavone

    7羟基黄酮

     A flavonoid with diverse biological activities
  15. GC42627 8-Hydroxyguanine (hydrochloride)

    依达比星杂质2

     Product of oxidative damage to DNA or RNA
  16. GC42642 9,10-Anthracenediyl-bis(methylene)dimalonic Acid

    9,10-蒽基-双(亚甲基)二丙二酸,ABMDMA

     A singlet oxygen acceptor
  17. GC42649 9-Nitrooleate

    9-硝基油酸

     A novel endogenous lipid signalling molecule
  18. GC19496 AAPH

    2,2'-偶氮二异丁基脒二盐酸盐

     A water-soluble azo compound used as a free radical generator
  19. GC63975 Acanthoside B

    刺五加提取物

     Acanthoside B 是一种具有抗炎、抗遗忘活性的生物活性木脂素。Acanthoside B 可用于阿尔茨海默病和肺部炎症等疾病的研究。
  20. GC11786 Acetylcysteine

    乙酰半胱氨酸; N-Acetylcysteine; N-Acetyl-L-cysteine; NAC

     乙酰半胱氨酸是半胱氨酸的 N-乙酰基衍生物。
  21. GN10298 Alibiflorin

    芍药内酯苷

     A monoterpene glycoside with diverse biological activities
  22. GC45379 Alloxan (hydrate)

    阿脲 一水合物

     A toxin that selectively eliminates pancreatic β-cells
  23. GC11443 Allylthiourea

    烯丙基硫脲; Thiosinamine; N-Allylthiourea

     烯丙基硫脲是一种选择性抑制氨氧化的代谢抑制剂。
  24. GC35306 alpha-Mangostin

    α-倒捻子素; α-Mangostin

     A xanthone with diverse biological activities
  25. GN10484 Amentoflavone

    穗花杉双黄酮; Didemethyl-ginkgetin

     A biflavonoid with diverse biological activities
  26. GC49336 AMK (hydrochloride)

    N-γ-acetyl-5-Methoxykynurenamine, N1-acetyl-5-Methoxykynuramine

     An active metabolite of melatonin
  27. GC49259 Antagonist G (trifluoroacetate salt)

    Arg-D-Trp-NmePhe-D-Trp-Leu-Met-NH2, Arg6,D-Trp7,9,NmePhe8-substance P (6-11)

     A neuropeptide antagonist
  28. GC70979 Anti-inflammatory agent 38 Anti-inflammatory agent 38(化合物23d)是一种有效的Nrf2/HO-1途径抑制剂，对NO的IC50值为0.38 μM。
  29. GC42825 APF APF是一种新型ROS指示剂，可选择性、剂量依赖性地与溶液和细胞中某些活性氧结合后产生荧光，其最大激发/发射波长分别为490/515nm。
  30. GN10509 Apigenin-7-O-β-D-glucopyranoside

    芹甙元-7-葡萄糖苷; Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigetrin

     A flavonoid
  31. GC52332 Arimoclomol

    BRX-220

     A co-inducer of heat shock proteins
  32. GC46005 Arjunolic Acid

    阿酚酸

     A triterpene with diverse biological activities
  33. GC70612 Arochlor 1254 Arochlor 1254是一种多氯联苯(PCB)混合物，含有联苯和54%的氯。
  34. GC12070 Ascorbic acid

    维生素C

     An electron donor
  35. GN10534 Asiaticoside

    积雪草苷

     A saponin with significant wound healing activity
  36. GC31350 Astaxanthin

    虾青素

     Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.
  37. GC48771 Avobenzone-13C-d3

    BMDBM-13C-d3, Butyl Methoxydibenzoylmethane-13C-d3

     An internal standard for the quantification of avobenzone
  38. GC46904 Azoxystrobin

    嘧菌酯

     A broad-spectrum fungicide
  39. GC60616 AZT triphosphate

    3'-Azido-3'-deoxythymidine-5'-triphosphate

    AZTtriphosphate(3'-Azido-3'-deoxythymidine-5'-triphosphate)是一种Zidovudine(AZT)的活性三磷酸酯代谢产物。AZTtriphosphate具有抗逆转录病毒的活性，并抑制HIV复制。AZTtriphosphate还可抑制HBV的DNA聚合酶。AZTtriphosphate可激活线粒体介导的凋亡(apoptosis)途径。
  40. GC60617 AZT triphosphate TEA

    3'-Azido-3'-deoxythymidine-5'-triphosphate TEA

     AZTtriphosphateTFA(3'-Azido-3'-deoxythymidine-5'-triphosphateTFA)是一种Zidovudine(AZT)的活性三磷酸酯代谢产物。AZTtriphosphateTFA具有抗逆转录病毒的活性，并抑制HIV复制。AZTtriphosphateTFA还可抑制HBV的DNA聚合酶。AZTtriphosphateTFA可激活线粒体介导的凋亡(apoptosis)途径。
  41. GC45820 Balsalazide-d4 Balsalazide-d4 是氘标记的 Balsalazide。
  42. GC17574 BAPTA

    1,2-双(2-氨基苯氧基)-乙烷-N,N,N`,N`-四乙酸

     An extracellular calcium chelator
  43. GC15949 Benfotiamine

    苯磷硫胺; S-Benzoylthiamine O-monophosphate

     A lipid-soluble form of vitamin B1
  44. GN10221 Berberine

    黄连素; Natural Yellow 18

    小檗碱（Natural Yellow 18）是一种从中草药黄连中分离出来的生物碱，作为一种抗生素。
  45. GC35497 Berberine chloride hydrate

    盐酸黄连素水合物; Natural Yellow 18 chloride hydrate

     As isoquinoline alkaloid with diverse biological activities
  46. GN10208 Berberine hydrochloride

    盐酸小檗碱; Natural Yellow 18 chloride

     盐酸小檗碱是来源于毛茛科药用植物黄连的一种异喹啉类生物碱，具有抗肿瘤、抗炎、降血糖等多种药理活性。
  47. GN10523 Berberine Sulfate

    硫酸小檗碱,Natural Yellow 18 sulfate

    硫酸小檗碱是一种从中草药黄连中分离出来的生物碱，作为一种抗生素。
  48. GC60076 Bigelovin

    锦菊素

     Bigelovin是可从海百合中分离得到的一种倍半萜内酯，是选择性的视黄素X受体α(retinoidXreceptorα)的激动剂。Bigelovin可通过诱导凋亡和自噬来发挥抗肿瘤活性。Bigelovin通过抑制ROS的生成来调节mTOR信号通路。
  49. GC49708 Biliverdin (technical grade)

    去氫膽紅素

     A bile pigment
  50. GC66485 Bis[3,4,6-trichloro-2-(pentyloxycarbonyl)phenyl] oxalate Bis[3,4,6-trichloro-2-(pentyloxycarbonyl)phenyl] oxalate 是一种活性较高的过草酸酯，可用于荧光染料检测H2O2。
  51. GC35529 Bixin

    胭脂树橙

     Bixin (BX) 红木素从 Bixa orellana 的种子中分离，一种类胡萝卜素，具有抗炎，抗肿瘤和抗氧化活性。Bixin (BX) 红木素通过抑制纤维化，炎症和活性氧 (ROS) 的产生来改善心脏功能障碍。

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